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Results: 1 to 20 of 178

1.

Human tumor antigens Tn and sialyl Tn arise from mutations in Cosmc.

Ju T, Lanneau GS, Gautam T, Wang Y, Xia B, Stowell SR, Willard MT, Wang W, Xia JY, Zuna RE, Laszik Z, Benbrook DM, Hanigan MH, Cummings RD.

Cancer Res. 2008 Mar 15;68(6):1636-46. doi: 10.1158/0008-5472.CAN-07-2345. Erratum in: Cancer Res. 2008 Apr 15;68(8):3076.

PMID:
18339842
[PubMed - indexed for MEDLINE]
Free Article
2.

New mutations in C1GALT1C1 in individuals with Tn positive phenotype.

Crew VK, Singleton BK, Green C, Parsons SF, Daniels G, Anstee DJ.

Br J Haematol. 2008 Aug;142(4):657-67. doi: 10.1111/j.1365-2141.2008.07215.x. Epub 2008 Jun 5.

PMID:
18537974
[PubMed - indexed for MEDLINE]
3.

The Cosmc connection to the Tn antigen in cancer.

Ju T, Aryal RP, Kudelka MR, Wang Y, Cummings RD.

Cancer Biomark. 2014 Jan 1;14(1):63-81. doi: 10.3233/CBM-130375. Review.

PMID:
24643043
[PubMed - indexed for MEDLINE]
4.

Protein glycosylation: chaperone mutation in Tn syndrome.

Ju T, Cummings RD.

Nature. 2005 Oct 27;437(7063):1252.

PMID:
16251947
[PubMed - indexed for MEDLINE]
5.

Pathways of mucin O-glycosylation in normal and malignant rat colonic epithelial cells reveal a mechanism for cancer-associated Sialyl-Tn antigen expression.

Brockhausen I, Yang J, Lehotay M, Ogata S, Itzkowitz S.

Biol Chem. 2001 Feb;382(2):219-32.

PMID:
11308020
[PubMed - indexed for MEDLINE]
6.

Tumor-associated carbohydrate antigens defining tumor malignancy: basis for development of anti-cancer vaccines.

Hakomori S.

Adv Exp Med Biol. 2001;491:369-402. Review.

PMID:
14533809
[PubMed - indexed for MEDLINE]
7.

Cloning and expression of a human gene encoding an N-acetylgalactosamine-alpha2,6-sialyltransferase (ST6GalNAc I): a candidate for synthesis of cancer-associated sialyl-Tn antigens.

Ikehara Y, Kojima N, Kurosawa N, Kudo T, Kono M, Nishihara S, Issiki S, Morozumi K, Itzkowitz S, Tsuda T, Nishimura SI, Tsuji S, Narimatsu H.

Glycobiology. 1999 Nov;9(11):1213-24.

PMID:
10536037
[PubMed - indexed for MEDLINE]
Free Article
8.

Role of the human ST6GalNAc-I and ST6GalNAc-II in the synthesis of the cancer-associated sialyl-Tn antigen.

Marcos NT, Pinho S, Grandela C, Cruz A, Samyn-Petit B, Harduin-Lepers A, Almeida R, Silva F, Morais V, Costa J, Kihlberg J, Clausen H, Reis CA.

Cancer Res. 2004 Oct 1;64(19):7050-7.

PMID:
15466199
[PubMed - indexed for MEDLINE]
Free Article
9.

Epigenetic silencing of the chaperone Cosmc in human leukocytes expressing tn antigen.

Mi R, Song L, Wang Y, Ding X, Zeng J, Lehoux S, Aryal RP, Wang J, Crew VK, van Die I, Chapman AB, Cummings RD, Ju T.

J Biol Chem. 2012 Nov 30;287(49):41523-33. doi: 10.1074/jbc.M112.371989. Epub 2012 Oct 3. Erratum in: J Biol Chem. 2013 Apr 19;288(16):11505.

PMID:
23035125
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Expression of sialyl-Tn antigen in breast cancer cells transfected with the human CMP-Neu5Ac: GalNAc alpha2,6-sialyltransferase (ST6GalNac I) cDNA.

Julien S, Krzewinski-Recchi MA, Harduin-Lepers A, Gouyer V, Huet G, Le Bourhis X, Delannoy P.

Glycoconj J. 2001 Nov-Dec;18(11-12):883-93.

PMID:
12820722
[PubMed - indexed for MEDLINE]
11.
12.

Coexpression of cancer-associated carbohydrate antigens, Tn and sialyl Tn.

Nakada H, Inoue M, Tanaka N, Yamashina I.

Glycoconj J. 1994 Jun;11(3):262-5.

PMID:
7841802
[PubMed - indexed for MEDLINE]
13.

Expression of Tn and sialyl-Tn antigens in the neoplastic transformation of uterine cervical epithelial cells.

Terasawa K, Furumoto H, Kamada M, Aono T.

Cancer Res. 1996 May 1;56(9):2229-32.

PMID:
8616877
[PubMed - indexed for MEDLINE]
Free Article
14.

Molecular basis of incomplete O-glycan synthesis in MCF-7 breast cancer cells: putative role of MUC6 in Tn antigen expression.

Freire T, Bay S, von Mensdorff-Pouilly S, Osinaga E.

Cancer Res. 2005 Sep 1;65(17):7880-7.

PMID:
16140958
[PubMed - indexed for MEDLINE]
Free Article
15.

Cosmc is an essential chaperone for correct protein O-glycosylation.

Wang Y, Ju T, Ding X, Xia B, Wang W, Xia L, He M, Cummings RD.

Proc Natl Acad Sci U S A. 2010 May 18;107(20):9228-33. doi: 10.1073/pnas.0914004107. Epub 2010 May 3.

PMID:
20439703
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Functional assays for the molecular chaperone cosmc.

Ju T, Cummings RD.

Methods Enzymol. 2010;479:107-22. doi: 10.1016/S0076-6879(10)79006-6.

PMID:
20816162
[PubMed - indexed for MEDLINE]
17.

Different expressions of sialyl Tn antigen between polypoid and flat-type early colorectal cancers.

Nanashima A, Nakagoe T, Sawai T, Nakamura S, Yamaguchi H, Yasutake T, Kusano H, Ayabe H.

Dis Colon Rectum. 1997 Oct;40(10 Suppl):S37-42.

PMID:
9378010
[PubMed - indexed for MEDLINE]
18.

Thomsen-Friedenreich antigen expression in gastric carcinomas is associated with MUC1 mucin VNTR polymorphism.

Santos-Silva F, Fonseca A, Caffrey T, Carvalho F, Mesquita P, Reis C, Almeida R, David L, Hollingsworth MA.

Glycobiology. 2005 May;15(5):511-7. Epub 2004 Dec 15.

PMID:
15604091
[PubMed - indexed for MEDLINE]
Free Article
19.

Simple mucin-type cancer associated antigens are pre-cancerous biomarkers during 1,2-dimethylhydrazine-induced rat colon carcinogenesis.

Berriel E, Hill M, Barcia JJ, Ubillos L, Gonzalez M, Detjen G, Rondan M, Navarrete H, Osinaga E.

Oncol Rep. 2005 Jul;14(1):219-27.

PMID:
15944793
[PubMed - indexed for MEDLINE]
20.

Stable expression of sialyl-Tn antigen in T47-D cells induces a decrease of cell adhesion and an increase of cell migration.

Julien S, Lagadec C, Krzewinski-Recchi MA, Courtand G, Le Bourhis X, Delannoy P.

Breast Cancer Res Treat. 2005 Mar;90(1):77-84.

PMID:
15770530
[PubMed - indexed for MEDLINE]

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