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Results: 1 to 20 of 135

1.

Mutations enhance the aggregation propensity of the Alzheimer's A beta peptide.

Kim W, Hecht MH.

J Mol Biol. 2008 Mar 21;377(2):565-74. doi: 10.1016/j.jmb.2007.12.079. Epub 2008 Jan 11.

PMID:
18258258
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Generic hydrophobic residues are sufficient to promote aggregation of the Alzheimer's Abeta42 peptide.

Kim W, Hecht MH.

Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15824-9. Epub 2006 Oct 12.

PMID:
17038501
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Mutations that reduce aggregation of the Alzheimer's Abeta42 peptide: an unbiased search for the sequence determinants of Abeta amyloidogenesis.

Wurth C, Guimard NK, Hecht MH.

J Mol Biol. 2002 Jun 21;319(5):1279-90.

PMID:
12079364
[PubMed - indexed for MEDLINE]
4.

Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin.

Betts V, Leissring MA, Dolios G, Wang R, Selkoe DJ, Walsh DM.

Neurobiol Dis. 2008 Sep;31(3):442-50. doi: 10.1016/j.nbd.2008.06.001. Epub 2008 Jun 17.

PMID:
18602473
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Design and evaluation of a 6-mer amyloid-beta protein derived phage display library for molecular targeting of amyloid plaques in Alzheimer's disease: Comparison with two cyclic heptapeptides derived from a randomized phage display library.

Larbanoix L, Burtea C, Ansciaux E, Laurent S, Mahieu I, Vander Elst L, Muller RN.

Peptides. 2011 Jun;32(6):1232-43. doi: 10.1016/j.peptides.2011.04.026. Epub 2011 May 6.

PMID:
21575663
[PubMed - indexed for MEDLINE]
6.

Sequence determinants of enhanced amyloidogenicity of Alzheimer A{beta}42 peptide relative to A{beta}40.

Kim W, Hecht MH.

J Biol Chem. 2005 Oct 14;280(41):35069-76. Epub 2005 Aug 3.

PMID:
16079141
[PubMed - indexed for MEDLINE]
Free Article
7.

Mutations that replace aromatic side chains promote aggregation of the Alzheimer's Aβ peptide.

Armstrong AH, Chen J, McKoy AF, Hecht MH.

Biochemistry. 2011 May 17;50(19):4058-67. doi: 10.1021/bi200268w. Epub 2011 Apr 22.

PMID:
21513285
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Expression and purification of 15N- and 13C-isotope labeled 40-residue human Alzheimer's β-amyloid peptide for NMR-based structural analysis.

Long F, Cho W, Ishii Y.

Protein Expr Purif. 2011 Sep;79(1):16-24. doi: 10.1016/j.pep.2011.05.012. Epub 2011 May 27.

PMID:
21640828
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Stability of transmembrane amyloid β-peptide and membrane integrity tested by molecular modeling of site-specific Aβ42 mutations.

Poojari C, Strodel B.

PLoS One. 2013 Nov 7;8(11):e78399. doi: 10.1371/journal.pone.0078399. eCollection 2013.

PMID:
24244308
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Effects of familial Alzheimer's disease mutations on the folding nucleation of the amyloid beta-protein.

Krone MG, Baumketner A, Bernstein SL, Wyttenbach T, Lazo ND, Teplow DB, Bowers MT, Shea JE.

J Mol Biol. 2008 Aug 1;381(1):221-8. doi: 10.1016/j.jmb.2008.05.069. Epub 2008 Jun 4.

PMID:
18597778
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Mutagenesis of the central hydrophobic cluster in Abeta42 Alzheimer's peptide. Side-chain properties correlate with aggregation propensities.

de Groot NS, Aviles FX, Vendrell J, Ventura S.

FEBS J. 2006 Feb;273(3):658-68.

PMID:
16420488
[PubMed - indexed for MEDLINE]
12.

Rationally designed turn promoting mutation in the amyloid-β peptide sequence stabilizes oligomers in solution.

Rajadas J, Liu CW, Novick P, Kelley NW, Inayathullah M, Lemieux MC, Pande VS.

PLoS One. 2011;6(7):e21776. doi: 10.1371/journal.pone.0021776. Epub 2011 Jul 22.

PMID:
21799748
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

DHPC strongly affects the structure and oligomerization propensity of Alzheimer's Aβ(1-40) peptide.

Dahse K, Garvey M, Kovermann M, Vogel A, Balbach J, Fändrich M, Fahr A.

J Mol Biol. 2010 Nov 5;403(4):643-59. doi: 10.1016/j.jmb.2010.09.021. Epub 2010 Sep 17.

PMID:
20851128
[PubMed - indexed for MEDLINE]
14.

Discovery of amyloid-beta aggregation inhibitors using an engineered assay for intracellular protein folding and solubility.

Lee LL, Ha H, Chang YT, DeLisa MP.

Protein Sci. 2009 Feb;18(2):277-86. doi: 10.1002/pro.33.

PMID:
19177561
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Structural heterogeneity in familial Alzheimer's disease mutants of amyloid-beta peptides.

Chong SH, Yim J, Ham S.

Mol Biosyst. 2013 May;9(5):997-1003. doi: 10.1039/c2mb25457c.

PMID:
23358498
[PubMed - indexed for MEDLINE]
16.

Effect of amino-acid substitutions on Alzheimer's amyloid-beta peptide-glycosaminoglycan interactions.

McLaurin J, Fraser PE.

Eur J Biochem. 2000 Nov;267(21):6353-61.

PMID:
11029577
[PubMed - indexed for MEDLINE]
Free Article
17.

The amyloid beta peptide: a chemist's perspective. Role in Alzheimer's and fibrillization.

Hamley IW.

Chem Rev. 2012 Oct 10;112(10):5147-92. doi: 10.1021/cr3000994. Epub 2012 Jul 19. Review. No abstract available.

PMID:
22813427
[PubMed - indexed for MEDLINE]
18.

Familial Alzheimer's disease mutations alter the stability of the amyloid beta-protein monomer folding nucleus.

Grant MA, Lazo ND, Lomakin A, Condron MM, Arai H, Yamin G, Rigby AC, Teplow DB.

Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16522-7. Epub 2007 Oct 10.

PMID:
17940047
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease.

Murakami K, Irie K, Morimoto A, Ohigashi H, Shindo M, Nagao M, Shimizu T, Shirasawa T.

J Biol Chem. 2003 Nov 14;278(46):46179-87. Epub 2003 Aug 27.

PMID:
12944403
[PubMed - indexed for MEDLINE]
Free Article
20.

A plant cell-based system that predicts aβ42 misfolding: potential as a drug discovery tool for Alzheimer's disease.

Zhao T, Zeng Y, Kermode AR.

Mol Genet Metab. 2012 Nov;107(3):571-9. doi: 10.1016/j.ymgme.2012.08.010. Epub 2012 Aug 18.

PMID:
22944366
[PubMed - indexed for MEDLINE]

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