Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Results: 1 to 20 of 114

1.

Multiple-ligand binding in CYP2A6: probing mechanisms of cytochrome P450 cooperativity by assessing substrate dynamics.

Harrelson JP, Atkins WM, Nelson SD.

Biochemistry. 2008 Mar 4;47(9):2978-88. doi: 10.1021/bi702020y. Epub 2008 Feb 5.

PMID:
18247580
[PubMed - indexed for MEDLINE]
2.

A comparison of substrate dynamics in human CYP2E1 and CYP2A6.

Harrelson JP, Henne KR, Alonso DO, Nelson SD.

Biochem Biophys Res Commun. 2007 Jan 26;352(4):843-9. Epub 2006 Nov 27.

PMID:
17156750
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Allosteric modulation of substrate motion in cytochrome P450 3A4-mediated xylene oxidation.

Childers WK, Harrelson JP.

Biochemistry. 2014 Feb 18;53(6):1018-28. doi: 10.1021/bi401472p. Epub 2014 Feb 6.

PMID:
24476063
[PubMed - indexed for MEDLINE]
4.

Active site characteristics of CYP4B1 probed with aromatic ligands.

Henne KR, Fisher MB, Iyer KR, Lang DH, Trager WF, Rettie AE.

Biochemistry. 2001 Jul 24;40(29):8597-605.

PMID:
11456500
[PubMed - indexed for MEDLINE]
5.

Elucidation of distinct ligand binding sites for cytochrome P450 3A4.

Hosea NA, Miller GP, Guengerich FP.

Biochemistry. 2000 May 23;39(20):5929-39.

PMID:
10821664
[PubMed - indexed for MEDLINE]
6.

Diclofenac and its derivatives as tools for studying human cytochromes P450 active sites: particular efficiency and regioselectivity of P450 2Cs.

Mancy A, Antignac M, Minoletti C, Dijols S, Mouries V, Duong NT, Battioni P, Dansette PM, Mansuy D.

Biochemistry. 1999 Oct 26;38(43):14264-70.

PMID:
10572000
[PubMed - indexed for MEDLINE]
7.

Kinetic analysis of oxidation of coumarins by human cytochrome P450 2A6.

Yun CH, Kim KH, Calcutt MW, Guengerich FP.

J Biol Chem. 2005 Apr 1;280(13):12279-91. Epub 2005 Jan 22.

PMID:
15665333
[PubMed - indexed for MEDLINE]
Free Article
8.

Ticlopidine as a selective mechanism-based inhibitor of human cytochrome P450 2C19.

Ha-Duong NT, Dijols S, Macherey AC, Goldstein JA, Dansette PM, Mansuy D.

Biochemistry. 2001 Oct 9;40(40):12112-22.

PMID:
11580286
[PubMed - indexed for MEDLINE]
9.

Differential behavior of the sub-sites of cytochrome 450 active site in binding of substrates, and products (implications for coupling/uncoupling).

Narasimhulu S.

Biochim Biophys Acta. 2007 Mar;1770(3):360-75. Epub 2006 Oct 5. Review.

PMID:
17134838
[PubMed - indexed for MEDLINE]
Free Article
10.

Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes.

Yamazaki H, Inoue K, Hashimoto M, Shimada T.

Arch Toxicol. 1999 Mar;73(2):65-70.

PMID:
10350185
[PubMed - indexed for MEDLINE]
11.

Human cytochrome P450 isozymes in metabolism and health effects of gasoline ethers.

Hong JY, Wang YY, Mohr SN, Bondoc FY, Deng C.

Res Rep Health Eff Inst. 2001 May;(102):7-27; discussion 95-109.

PMID:
11504148
[PubMed - indexed for MEDLINE]
12.
13.

Key residues controlling binding of diverse ligands to human cytochrome P450 2A enzymes.

DeVore NM, Smith BD, Wang JL, Lushington GH, Scott EE.

Drug Metab Dispos. 2009 Jun;37(6):1319-27. doi: 10.1124/dmd.109.026765. Epub 2009 Feb 27.

PMID:
19251817
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Dual role of human cytochrome P450 3A4 residue Phe-304 in substrate specificity and cooperativity.

Domanski TL, He YA, Harlow GR, Halpert JR.

J Pharmacol Exp Ther. 2000 May;293(2):585-91.

PMID:
10773032
[PubMed - indexed for MEDLINE]
Free Article
16.

Roles of CYP3A4 and CYP2C19 in methyl hydroxylated and N-oxidized metabolite formation from voriconazole, a new anti-fungal agent, in human liver microsomes.

Murayama N, Imai N, Nakane T, Shimizu M, Yamazaki H.

Biochem Pharmacol. 2007 Jun 15;73(12):2020-6. Epub 2007 Mar 19.

PMID:
17433262
[PubMed - indexed for MEDLINE]
17.

Time-dependent effects of o-xylene on rat lung and liver microsomal membrane structure and function.

Park SH, AuCoin TA, Silverman DM, Schatz RA.

J Toxicol Environ Health. 1994 Dec;43(4):469-81.

PMID:
7990171
[PubMed - indexed for MEDLINE]
18.

Cytochrome P450 3A4-catalyzed testosterone 6beta-hydroxylation stereochemistry, kinetic deuterium isotope effects, and rate-limiting steps.

Krauser JA, Guengerich FP.

J Biol Chem. 2005 May 20;280(20):19496-506. Epub 2005 Mar 15.

PMID:
15772082
[PubMed - indexed for MEDLINE]
Free Article
19.

Evaluation of atypical cytochrome P450 kinetics with two-substrate models: evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites.

Korzekwa KR, Krishnamachary N, Shou M, Ogai A, Parise RA, Rettie AE, Gonzalez FJ, Tracy TS.

Biochemistry. 1998 Mar 24;37(12):4137-47.

PMID:
9521735
[PubMed - indexed for MEDLINE]
20.

Metabolism of 2,5-bis(trifluoromethyl)-7-benzyloxy-4-trifluoromethylcoumarin by human hepatic CYP isoforms: evidence for selectivity towards CYP3A4.

Renwick AB, Lewis DF, Fulford S, Surry D, Williams B, Worboys PD, Cai X, Wang RW, Price RJ, Lake BG, Evans DC.

Xenobiotica. 2001 Apr;31(4):187-204.

PMID:
11465405
[PubMed - indexed for MEDLINE]

Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk