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Results: 1 to 20 of 181

1.

Ubiquitination by TOPORS regulates the prostate tumor suppressor NKX3.1.

Guan B, Pungaliya P, Li X, Uquillas C, Mutton LN, Rubin EH, Bieberich CJ.

J Biol Chem. 2008 Feb 22;283(8):4834-40. Epub 2007 Dec 12.

PMID:
18077445
[PubMed - indexed for MEDLINE]
Free Article
2.

Topors acts as a SUMO-1 E3 ligase for p53 in vitro and in vivo.

Weger S, Hammer E, Heilbronn R.

FEBS Lett. 2005 Sep 12;579(22):5007-12.

PMID:
16122737
[PubMed - indexed for MEDLINE]
Free Article
3.

Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53.

Rajendra R, Malegaonkar D, Pungaliya P, Marshall H, Rasheed Z, Brownell J, Liu LF, Lutzker S, Saleem A, Rubin EH.

J Biol Chem. 2004 Aug 27;279(35):36440-4. Epub 2004 Jul 9.

PMID:
15247280
[PubMed - indexed for MEDLINE]
Free Article
4.

Proline-mediated proteasomal degradation of the prostate-specific tumor suppressor NKX3.1.

Rao V, Guan B, Mutton LN, Bieberich CJ.

J Biol Chem. 2012 Oct 19;287(43):36331-40. doi: 10.1074/jbc.M112.352823. Epub 2012 Aug 21.

PMID:
22910912
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

WW domain-containing E3 ubiquitin protein ligase 1 targets p63 transcription factor for ubiquitin-mediated proteasomal degradation and regulates apoptosis.

Li Y, Zhou Z, Chen C.

Cell Death Differ. 2008 Dec;15(12):1941-51. doi: 10.1038/cdd.2008.134. Epub 2008 Sep 19.

PMID:
18806757
[PubMed - indexed for MEDLINE]
Free Article
6.

Plk1-mediated phosphorylation of Topors regulates p53 stability.

Yang X, Li H, Zhou Z, Wang WH, Deng A, Andrisani O, Liu X.

J Biol Chem. 2009 Jul 10;284(28):18588-92. doi: 10.1074/jbc.C109.001560. Epub 2009 May 27.

PMID:
19473992
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss.

Lei Q, Jiao J, Xin L, Chang CJ, Wang S, Gao J, Gleave ME, Witte ON, Liu X, Wu H.

Cancer Cell. 2006 May;9(5):367-78.

PMID:
16697957
[PubMed - indexed for MEDLINE]
Free Article
8.

Identification of phosphorylation sites of TOPORS and a role for serine 98 in the regulation of ubiquitin but not SUMO E3 ligase activity.

Park HJ, Zheng H, Kulkarni D, Kerrigan J, Pungaliya P, Saleem A, Rubin EH.

Biochemistry. 2008 Dec 30;47(52):13887-96. doi: 10.1021/bi801904q.

PMID:
19053840
[PubMed - indexed for MEDLINE]
9.

The topoisomerase I- and p53-binding protein topors is differentially expressed in normal and malignant human tissues and may function as a tumor suppressor.

Saleem A, Dutta J, Malegaonkar D, Rasheed F, Rasheed Z, Rajendra R, Marshall H, Luo M, Li H, Rubin EH.

Oncogene. 2004 Jul 8;23(31):5293-300.

PMID:
15107820
[PubMed - indexed for MEDLINE]
10.

Physical and functional interactions between the prostate suppressor homeoprotein NKX3.1 and serum response factor.

Ju JH, Maeng JS, Zemedkun M, Ahronovitz N, Mack JW, Ferretti JA, Gelmann EP, Gruschus JM.

J Mol Biol. 2006 Jul 28;360(5):989-99. Epub 2006 Jun 15.

PMID:
16814806
[PubMed - indexed for MEDLINE]
11.

topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage.

Lin L, Ozaki T, Takada Y, Kageyama H, Nakamura Y, Hata A, Zhang JH, Simonds WF, Nakagawara A, Koseki H.

Oncogene. 2005 May 12;24(21):3385-96.

PMID:
15735665
[PubMed - indexed for MEDLINE]
12.

Mechanisms of prostate tumorigenesis: roles for transcription factors Nkx3.1 and Egr1.

Abdulkadir SA.

Ann N Y Acad Sci. 2005 Nov;1059:33-40. Review.

PMID:
16382041
[PubMed - indexed for MEDLINE]
13.

Deletion, methylation, and expression of the NKX3.1 suppressor gene in primary human prostate cancer.

Asatiani E, Huang WX, Wang A, Rodriguez Ortner E, Cavalli LR, Haddad BR, Gelmann EP.

Cancer Res. 2005 Feb 15;65(4):1164-73.

PMID:
15734999
[PubMed - indexed for MEDLINE]
Free Article
14.

Loss of NKX3.1 expression in human prostate cancers correlates with tumor progression.

Bowen C, Bubendorf L, Voeller HJ, Slack R, Willi N, Sauter G, Gasser TC, Koivisto P, Lack EE, Kononen J, Kallioniemi OP, Gelmann EP.

Cancer Res. 2000 Nov 1;60(21):6111-5.

PMID:
11085535
[PubMed - indexed for MEDLINE]
Free Article
15.

Germ-line mutation of NKX3.1 cosegregates with hereditary prostate cancer and alters the homeodomain structure and function.

Zheng SL, Ju JH, Chang BL, Ortner E, Sun J, Isaacs SD, Sun J, Wiley KE, Liu W, Zemedkun M, Walsh PC, Ferretti J, Gruschus J, Isaacs WB, Gelmann EP, Xu J.

Cancer Res. 2006 Jan 1;66(1):69-77.

PMID:
16397218
[PubMed - indexed for MEDLINE]
Free Article
16.

Conditional loss of Nkx3.1 in adult mice induces prostatic intraepithelial neoplasia.

Abdulkadir SA, Magee JA, Peters TJ, Kaleem Z, Naughton CK, Humphrey PA, Milbrandt J.

Mol Cell Biol. 2002 Mar;22(5):1495-503.

PMID:
11839815
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Nkx3.1 and p27(KIP1) cooperate in proliferation inhibition and apoptosis induction in human androgen-independent prostate cancer cells.

Wang P, Ma Q, Luo J, Liu B, Tan F, Zhang Z, Chen Z.

Cancer Invest. 2009 May;27(4):369-75. doi: 10.1080/07357900802232749.

PMID:
19266349
[PubMed - indexed for MEDLINE]
18.
19.

TOPORS functions as a SUMO-1 E3 ligase for chromatin-modifying proteins.

Pungaliya P, Kulkarni D, Park HJ, Marshall H, Zheng H, Lackland H, Saleem A, Rubin EH.

J Proteome Res. 2007 Oct;6(10):3918-23. Epub 2007 Sep 6.

PMID:
17803295
[PubMed - indexed for MEDLINE]
20.

NKX3.1 homeodomain protein binds to topoisomerase I and enhances its activity.

Bowen C, Stuart A, Ju JH, Tuan J, Blonder J, Conrads TP, Veenstra TD, Gelmann EP.

Cancer Res. 2007 Jan 15;67(2):455-64.

PMID:
17234752
[PubMed - indexed for MEDLINE]
Free Article

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