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Results: 1 to 20 of 190

1.

PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis.

Huang G, Zhang P, Hirai H, Elf S, Yan X, Chen Z, Koschmieder S, Okuno Y, Dayaram T, Growney JD, Shivdasani RA, Gilliland DG, Speck NA, Nimer SD, Tenen DG.

Nat Genet. 2008 Jan;40(1):51-60. Epub 2007 Nov 11. Erratum in: Nat Genet. 2008 Feb;40(2):255.

PMID:
17994017
[PubMed - indexed for MEDLINE]
2.

The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia.

Vangala RK, Heiss-Neumann MS, Rangatia JS, Singh SM, Schoch C, Tenen DG, Hiddemann W, Behre G.

Blood. 2003 Jan 1;101(1):270-7. Epub 2002 Aug 29.

PMID:
12393465
[PubMed - indexed for MEDLINE]
Free Article
3.

The Pu.1 locus is differentially regulated at the level of chromatin structure and noncoding transcription by alternate mechanisms at distinct developmental stages of hematopoiesis.

Hoogenkamp M, Krysinska H, Ingram R, Huang G, Barlow R, Clarke D, Ebralidze A, Zhang P, Tagoh H, Cockerill PN, Tenen DG, Bonifer C.

Mol Cell Biol. 2007 Nov;27(21):7425-38. Epub 2007 Sep 4.

PMID:
17785440
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Subnuclear targeting of Runx1 is required for synergistic activation of the myeloid specific M-CSF receptor promoter by PU.1.

Li X, Vradii D, Gutierrez S, Lian JB, van Wijnen AJ, Stein JL, Stein GS, Javed A.

J Cell Biochem. 2005 Nov 1;96(4):795-809.

PMID:
16149049
[PubMed - indexed for MEDLINE]
5.

Cell-type-specific activation and repression of PU.1 by a complex of discrete, functionally specialized cis-regulatory elements.

Zarnegar MA, Chen J, Rothenberg EV.

Mol Cell Biol. 2010 Oct;30(20):4922-39. doi: 10.1128/MCB.00354-10. Epub 2010 Aug 9.

PMID:
20696839
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Inability of RUNX1/AML1 to breach AML1-ETO block of embryonic stem cell definitive hematopoiesis.

Peterson LF, Lo MC, Okumura AJ, Zhang DE.

Blood Cells Mol Dis. 2007 Nov-Dec;39(3):321-8. Epub 2007 Aug 9.

PMID:
17692541
[PubMed - indexed for MEDLINE]
7.

AML1/Runx1 as a versatile regulator of hematopoiesis: regulation of its function and a role in adult hematopoiesis.

Kurokawa M.

Int J Hematol. 2006 Aug;84(2):136-42. Review.

PMID:
16926135
[PubMed - indexed for MEDLINE]
8.

VWRPY motif-dependent and -independent roles of AML1/Runx1 transcription factor in murine hematopoietic development.

Nishimura M, Fukushima-Nakase Y, Fujita Y, Nakao M, Toda S, Kitamura N, Abe T, Okuda T.

Blood. 2004 Jan 15;103(2):562-70. Epub 2003 Sep 22.

PMID:
14504086
[PubMed - indexed for MEDLINE]
Free Article
9.

Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1.

Rosenbauer F, Owens BM, Yu L, Tumang JR, Steidl U, Kutok JL, Clayton LK, Wagner K, Scheller M, Iwasaki H, Liu C, Hackanson B, Akashi K, Leutz A, Rothstein TL, Plass C, Tenen DG.

Nat Genet. 2006 Jan;38(1):27-37. Epub 2005 Nov 27.

PMID:
16311598
[PubMed - indexed for MEDLINE]
10.

Biological characteristics of the leukemia-associated transcriptional factor AML1 disclosed by hematopoietic rescue of AML1-deficient embryonic stem cells by using a knock-in strategy.

Okuda T, Takeda K, Fujita Y, Nishimura M, Yagyu S, Yoshida M, Akira S, Downing JR, Abe T.

Mol Cell Biol. 2000 Jan;20(1):319-28.

PMID:
10594034
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

The transcriptionally active form of AML1 is required for hematopoietic rescue of the AML1-deficient embryonic para-aortic splanchnopleural (P-Sp) region.

Goyama S, Yamaguchi Y, Imai Y, Kawazu M, Nakagawa M, Asai T, Kumano K, Mitani K, Ogawa S, Chiba S, Kurokawa M, Hirai H.

Blood. 2004 Dec 1;104(12):3558-64. Epub 2004 Jul 22.

PMID:
15271791
[PubMed - indexed for MEDLINE]
Free Article
12.

Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation.

Aikawa Y, Nguyen LA, Isono K, Takakura N, Tagata Y, Schmitz ML, Koseki H, Kitabayashi I.

EMBO J. 2006 Sep 6;25(17):3955-65. Epub 2006 Aug 17.

PMID:
16917507
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

AML1/Runx1 negatively regulates quiescent hematopoietic stem cells in adult hematopoiesis.

Ichikawa M, Goyama S, Asai T, Kawazu M, Nakagawa M, Takeshita M, Chiba S, Ogawa S, Kurokawa M.

J Immunol. 2008 Apr 1;180(7):4402-8.

PMID:
18354160
[PubMed - indexed for MEDLINE]
Free Article
14.

The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.

Huang G, Zhao X, Wang L, Elf S, Xu H, Zhao X, Sashida G, Zhang Y, Liu Y, Lee J, Menendez S, Yang Y, Yan X, Zhang P, Tenen DG, Osato M, Hsieh JJ, Nimer SD.

Blood. 2011 Dec 15;118(25):6544-52. doi: 10.1182/blood-2010-11-317909. Epub 2011 Oct 19.

PMID:
22012064
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

AML1(-/-) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene.

Okada H, Watanabe T, Niki M, Takano H, Chiba N, Yanai N, Tani K, Hibino H, Asano S, Mucenski ML, Ito Y, Noda T, Satake M.

Oncogene. 1998 Nov 5;17(18):2287-93.

PMID:
9811459
[PubMed - indexed for MEDLINE]
Free Article
16.

AML1 interconnected pathways of leukemogenesis.

Michaud J, Scott HS, Escher R.

Cancer Invest. 2003;21(1):105-36. Review. Erratum in: Cancer Invest. 2003;21(4):659.

PMID:
12643014
[PubMed - indexed for MEDLINE]
17.

Regulation of the PU.1 gene by distal elements.

Li Y, Okuno Y, Zhang P, Radomska HS, Chen H, Iwasaki H, Akashi K, Klemsz MJ, McKercher SR, Maki RA, Tenen DG.

Blood. 2001 Nov 15;98(10):2958-65.

PMID:
11698277
[PubMed - indexed for MEDLINE]
Free Article
18.

Dysplastic definitive hematopoiesis in AML1/EVI1 knock-in embryos.

Maki K, Yamagata T, Asai T, Yamazaki I, Oda H, Hirai H, Mitani K.

Blood. 2005 Sep 15;106(6):2147-55. Epub 2005 May 24.

PMID:
15914564
[PubMed - indexed for MEDLINE]
Free Article
19.

Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.

Rosenbauer F, Wagner K, Kutok JL, Iwasaki H, Le Beau MM, Okuno Y, Akashi K, Fiering S, Tenen DG.

Nat Genet. 2004 Jun;36(6):624-30. Epub 2004 May 16.

PMID:
15146183
[PubMed - indexed for MEDLINE]
20.

AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression.

Yeh JR, Munson KM, Chao YL, Peterson QP, Macrae CA, Peterson RT.

Development. 2008 Jan;135(2):401-10.

PMID:
18156164
[PubMed - indexed for MEDLINE]
Free Article

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