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Insulin action in the double incretin receptor knockout mouse.

Ayala JE, Bracy DP, Hansotia T, Flock G, Seino Y, Wasserman DH, Drucker DJ.

Diabetes. 2008 Feb;57(2):288-97. Epub 2007 Oct 31.


Glucagon-like peptide-1 receptor knockout mice are protected from high-fat diet-induced insulin resistance.

Ayala JE, Bracy DP, James FD, Burmeister MA, Wasserman DH, Drucker DJ.

Endocrinology. 2010 Oct;151(10):4678-87. doi: 10.1210/en.2010-0289. Epub 2010 Aug 4.


Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors.

Hansotia T, Baggio LL, Delmeire D, Hinke SA, Yamada Y, Tsukiyama K, Seino Y, Holst JJ, Schuit F, Drucker DJ.

Diabetes. 2004 May;53(5):1326-35.


The glucagon-like peptide-1 receptor regulates endogenous glucose production and muscle glucose uptake independent of its incretin action.

Ayala JE, Bracy DP, James FD, Julien BM, Wasserman DH, Drucker DJ.

Endocrinology. 2009 Mar;150(3):1155-64. doi: 10.1210/en.2008-0945. Epub 2008 Nov 13.


Differential importance of glucose-dependent insulinotropic polypeptide vs glucagon-like peptide 1 receptor signaling for beta cell survival in mice.

Maida A, Hansotia T, Longuet C, Seino Y, Drucker DJ.

Gastroenterology. 2009 Dec;137(6):2146-57. doi: 10.1053/j.gastro.2009.09.004. Epub 2009 Sep 17.


Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure.

Hansotia T, Maida A, Flock G, Yamada Y, Tsukiyama K, Seino Y, Drucker DJ.

J Clin Invest. 2007 Jan;117(1):143-52. Epub 2006 Dec 21.


Hexokinase II overexpression improves exercise-stimulated but not insulin-stimulated muscle glucose uptake in high-fat-fed C57BL/6J mice.

Fueger PT, Bracy DP, Malabanan CM, Pencek RR, Granner DK, Wasserman DH.

Diabetes. 2004 Feb;53(2):306-14.


GPR119 regulates murine glucose homeostasis through incretin receptor-dependent and independent mechanisms.

Flock G, Holland D, Seino Y, Drucker DJ.

Endocrinology. 2011 Feb;152(2):374-83. doi: 10.1210/en.2010-1047. Epub 2010 Nov 10.


GIP and GLP-1 as incretin hormones: lessons from single and double incretin receptor knockout mice.

Hansotia T, Drucker DJ.

Regul Pept. 2005 Jun 15;128(2):125-34. Review.


Acute activation of central GLP-1 receptors enhances hepatic insulin action and insulin secretion in high-fat-fed, insulin resistant mice.

Burmeister MA, Ferre T, Ayala JE, King EM, Holt RM, Ayala JE.

Am J Physiol Endocrinol Metab. 2012 Feb 1;302(3):E334-43. doi: 10.1152/ajpendo.00409.2011. Epub 2011 Nov 15.


Phosphorylation barriers to skeletal and cardiac muscle glucose uptakes in high-fat fed mice: studies in mice with a 50% reduction of hexokinase II.

Fueger PT, Lee-Young RS, Shearer J, Bracy DP, Heikkinen S, Laakso M, Rottman JN, Wasserman DH.

Diabetes. 2007 Oct;56(10):2476-84. Epub 2007 Jul 16.


Myostatin inhibition in muscle, but not adipose tissue, decreases fat mass and improves insulin sensitivity.

Guo T, Jou W, Chanturiya T, Portas J, Gavrilova O, McPherron AC.

PLoS One. 2009;4(3):e4937. doi: 10.1371/journal.pone.0004937. Epub 2009 Mar 19.


Elevated glucagon-like peptide-1-(7-36)-amide, but not glucose, associated with hyperinsulinemic compensation for fat feeding.

van Citters GW, Kabir M, Kim SP, Mittelman SD, Dea MK, Brubaker PL, Bergman RN.

J Clin Endocrinol Metab. 2002 Nov;87(11):5191-8.


Incretin hormone receptors are required for normal beta cell development and function in female mice.

Omar B, Ahlkvist L, Yamada Y, Seino Y, Ahrén B.

Peptides. 2016 May;79:58-65. doi: 10.1016/j.peptides.2016.03.012. Epub 2016 Mar 25.


COMP-angiopoietin-1 enhances skeletal muscle blood flow and insulin sensitivity in mice.

Sung HK, Kim YW, Choi SJ, Kim JY, Jeune KH, Won KC, Kim JK, Koh GY, Park SY.

Am J Physiol Endocrinol Metab. 2009 Aug;297(2):E402-9. doi: 10.1152/ajpendo.00122.2009. Epub 2009 Jun 2. Erratum in: Am J Physiol Endocrinol Metab. 2009 Nov;297(5):E1233. Sung, H K [corrected to Sung, Hoon-Ki];Koh, Gyu Young [corrected to Koh, Gou Young].


Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding.

Oakes ND, Cooney GJ, Camilleri S, Chisholm DJ, Kraegen EW.

Diabetes. 1997 Nov;46(11):1768-74.


Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouse.

Ayala JE, Bracy DP, McGuinness OP, Wasserman DH.

Diabetes. 2006 Feb;55(2):390-7.


Knockout of STAT3 in skeletal muscle does not prevent high-fat diet-induced insulin resistance.

White AT, LaBarge SA, McCurdy CE, Schenk S.

Mol Metab. 2015 May 13;4(8):569-75. doi: 10.1016/j.molmet.2015.05.001. eCollection 2015 Aug.

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