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Results: 1 to 20 of 218

1.

Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits.

DiFiglia M, Sena-Esteves M, Chase K, Sapp E, Pfister E, Sass M, Yoder J, Reeves P, Pandey RK, Rajeev KG, Manoharan M, Sah DW, Zamore PD, Aronin N.

Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17204-9. Epub 2007 Oct 16.

PMID:
17940007
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Clinico-pathological rescue of a model mouse of Huntington's disease by siRNA.

Wang YL, Liu W, Wada E, Murata M, Wada K, Kanazawa I.

Neurosci Res. 2005 Nov;53(3):241-9. Epub 2005 Aug 10.

PMID:
16095740
[PubMed - indexed for MEDLINE]
3.

High-capacity adenoviral vector-mediated reduction of huntingtin aggregate load in vitro and in vivo.

Huang B, Schiefer J, Sass C, Landwehrmeyer GB, Kosinski CM, Kochanek S.

Hum Gene Ther. 2007 Apr;18(4):303-11.

PMID:
17472569
[PubMed - indexed for MEDLINE]
4.

Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease.

Van Raamsdonk JM, Pearson J, Murphy Z, Hayden MR, Leavitt BR.

BMC Neurosci. 2006 Dec 5;7:80.

PMID:
17147801
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Striatal expression of a calmodulin fragment improved motor function, weight loss, and neuropathology in the R6/2 mouse model of Huntington's disease.

Dai Y, Dudek NL, Li Q, Fowler SC, Muma NA.

J Neurosci. 2009 Sep 16;29(37):11550-9. doi: 10.1523/JNEUROSCI.3307-09.2009.

PMID:
19759302
[PubMed - indexed for MEDLINE]
Free Article
6.

Characterization of a rat model of Huntington's disease based on targeted expression of mutant huntingtin in the forebrain using adeno-associated viral vectors.

Gabery S, Sajjad MU, Hult S, Soylu R, Kirik D, Petersén Å.

Eur J Neurosci. 2012 Sep;36(6):2789-800. doi: 10.1111/j.1460-9568.2012.08193.x. Epub 2012 Jun 25.

PMID:
22731249
[PubMed - indexed for MEDLINE]
7.

rAAV-mediated shRNA ameliorated neuropathology in Huntington disease model mouse.

Machida Y, Okada T, Kurosawa M, Oyama F, Ozawa K, Nukina N.

Biochem Biophys Res Commun. 2006 Apr 28;343(1):190-7. Epub 2006 Mar 3.

PMID:
16530728
[PubMed - indexed for MEDLINE]
8.

Msh2 acts in medium-spiny striatal neurons as an enhancer of CAG instability and mutant huntingtin phenotypes in Huntington's disease knock-in mice.

Kovalenko M, Dragileva E, St Claire J, Gillis T, Guide JR, New J, Dong H, Kucherlapati R, Kucherlapati MH, Ehrlich ME, Lee JM, Wheeler VC.

PLoS One. 2012;7(9):e44273. doi: 10.1371/journal.pone.0044273. Epub 2012 Sep 7.

PMID:
22970194
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin.

Tanaka Y, Igarashi S, Nakamura M, Gafni J, Torcassi C, Schilling G, Crippen D, Wood JD, Sawa A, Jenkins NA, Copeland NG, Borchelt DR, Ross CA, Ellerby LM.

Neurobiol Dis. 2006 Feb;21(2):381-91. Epub 2005 Sep 16.

PMID:
16150600
[PubMed - indexed for MEDLINE]
10.

Sustained effects of nonallele-specific Huntingtin silencing.

Drouet V, Perrin V, Hassig R, Dufour N, Auregan G, Alves S, Bonvento G, Brouillet E, Luthi-Carter R, Hantraye P, Déglon N.

Ann Neurol. 2009 Mar;65(3):276-85. doi: 10.1002/ana.21569.

PMID:
19334076
[PubMed - indexed for MEDLINE]
11.

Viral delivery of glial cell line-derived neurotrophic factor improves behavior and protects striatal neurons in a mouse model of Huntington's disease.

McBride JL, Ramaswamy S, Gasmi M, Bartus RT, Herzog CD, Brandon EP, Zhou L, Pitzer MR, Berry-Kravis EM, Kordower JH.

Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9345-50. Epub 2006 Jun 2.

PMID:
16751280
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Nonallele-specific silencing of mutant and wild-type huntingtin demonstrates therapeutic efficacy in Huntington's disease mice.

Boudreau RL, McBride JL, Martins I, Shen S, Xing Y, Carter BJ, Davidson BL.

Mol Ther. 2009 Jun;17(6):1053-63. doi: 10.1038/mt.2009.17. Epub 2009 Feb 24.

PMID:
19240687
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease.

Hermel E, Gafni J, Propp SS, Leavitt BR, Wellington CL, Young JE, Hackam AS, Logvinova AV, Peel AL, Chen SF, Hook V, Singaraja R, Krajewski S, Goldsmith PC, Ellerby HM, Hayden MR, Bredesen DE, Ellerby LM.

Cell Death Differ. 2004 Apr;11(4):424-38.

PMID:
14713958
[PubMed - indexed for MEDLINE]
Free Article
14.

Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats.

Menalled LB, Sison JD, Dragatsis I, Zeitlin S, Chesselet MF.

J Comp Neurol. 2003 Oct 6;465(1):11-26.

PMID:
12926013
[PubMed - indexed for MEDLINE]
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17.

Transgenic mice expressing mutated full-length HD cDNA: a paradigm for locomotor changes and selective neuronal loss in Huntington's disease.

Reddy PH, Charles V, Williams M, Miller G, Whetsell WO Jr, Tagle DA.

Philos Trans R Soc Lond B Biol Sci. 1999 Jun 29;354(1386):1035-45.

PMID:
10434303
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease.

Van Raamsdonk JM, Murphy Z, Slow EJ, Leavitt BR, Hayden MR.

Hum Mol Genet. 2005 Dec 15;14(24):3823-35. Epub 2005 Nov 8.

PMID:
16278236
[PubMed - indexed for MEDLINE]
Free Article
19.

Dendritic spine pathology and deficits in experience-dependent dendritic plasticity in R6/1 Huntington's disease transgenic mice.

Spires TL, Grote HE, Garry S, Cordery PM, Van Dellen A, Blakemore C, Hannan AJ.

Eur J Neurosci. 2004 May;19(10):2799-807.

PMID:
15147313
[PubMed - indexed for MEDLINE]
20.

Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice.

Bradford J, Shin JY, Roberts M, Wang CE, Sheng G, Li S, Li XJ.

J Biol Chem. 2010 Apr 2;285(14):10653-61. doi: 10.1074/jbc.M109.083287. Epub 2010 Feb 9.

PMID:
20145253
[PubMed - indexed for MEDLINE]
Free PMC Article

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