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1.

CYP2A13: variable expression and role in human lung microsomal metabolic activation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

Zhang X, D'Agostino J, Wu H, Zhang QY, von Weymarn L, Murphy SE, Ding X.

J Pharmacol Exp Ther. 2007 Nov;323(2):570-8. Epub 2007 Aug 1.

3.

Analysis of CYP2A contributions to metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human peripheral lung microsomes.

Brown PJ, Bedard LL, Reid KR, Petsikas D, Massey TE.

Drug Metab Dispos. 2007 Nov;35(11):2086-94. Epub 2007 Aug 23.

5.

Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation--a mammalian cell-based mutagenesis approach.

Chiang HC, Wang CY, Lee HL, Tsou TC.

Toxicol Appl Pharmacol. 2011 Jun 1;253(2):145-52. doi: 10.1016/j.taap.2011.03.022. Epub 2011 Apr 4.

PMID:
21473878
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Mechanisms of chemopreventive effects of 8-methoxypsoralen against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung adenomas.

Miyazaki M, Yamazaki H, Takeuchi H, Saoo K, Yokohira M, Masumura K, Nohmi T, Funae Y, Imaida K, Kamataki T.

Carcinogenesis. 2005 Nov;26(11):1947-55. Epub 2005 Jun 15. Erratum in: Carcinogenesis. 2005 Dec;26(12):2214.

9.

Enzymes involved in the bioactivation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in patas monkey lung and liver microsomes.

Smith TJ, Liao AM, Liu Y, Jones AB, Anderson LM, Yang CS.

Carcinogenesis. 1997 Aug;18(8):1577-84.

10.

Role of CYP2A5 in the bioactivation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice.

Zhou X, D'Agostino J, Xie F, Ding X.

J Pharmacol Exp Ther. 2012 Apr;341(1):233-41. doi: 10.1124/jpet.111.190173. Epub 2012 Jan 19.

11.

Biotransformation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in peripheral human lung microsomes.

Smith GB, Bend JR, Bedard LL, Reid KR, Petsikas D, Massey TE.

Drug Metab Dispos. 2003 Sep;31(9):1134-41.

12.

Metabolic activation of the tobacco carcinogen 4-(methylnitrosamino)-(3-pyridyl)-1-butanone by cytochrome P450 2A13 in human fetal nasal microsomes.

Wong HL, Zhang X, Zhang QY, Gu J, Ding X, Hecht SS, Murphy SE.

Chem Res Toxicol. 2005 Jun;18(6):913-8.

PMID:
15962925
14.

CYP2A13 in human respiratory tissues and lung cancers: an immunohistochemical study with a new peptide-specific antibody.

Zhu LR, Thomas PE, Lu G, Reuhl KR, Yang GY, Wang LD, Wang SL, Yang CS, He XY, Hong JY.

Drug Metab Dispos. 2006 Oct;34(10):1672-6. Epub 2006 Jun 30.

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Biotransformation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in freshly isolated human lung cells.

Smith GB, Castonguay A, Donnelly PJ, Reid KR, Petsikas D, Massey TE.

Carcinogenesis. 1999 Sep;20(9):1809-18. Erratum in: Carcinogenesis 2000 Jun;21(6):1267.

19.

Nasal cytochrome P450 2A: identification, regional localization, and metabolic activity toward hexamethylphosphoramide, a known nasal carcinogen.

Thornton-Manning JR, Nikula KJ, Hotchkiss JA, Avila KJ, Rohrbacher KD, Ding X, Dahl AR.

Toxicol Appl Pharmacol. 1997 Jan;142(1):22-30.

PMID:
9007030
20.
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