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Results: 1 to 20 of 140

1.

Hyperforin--a key constituent of St. John's wort specifically activates TRPC6 channels.

Leuner K, Kazanski V, Müller M, Essin K, Henke B, Gollasch M, Harteneck C, Müller WE.

FASEB J. 2007 Dec;21(14):4101-11. Epub 2007 Jul 31.

PMID:
17666455
[PubMed - indexed for MEDLINE]
Free Article
2.

Hyperforin modulates dendritic spine morphology in hippocampal pyramidal neurons by activating Ca(2+) -permeable TRPC6 channels.

Leuner K, Li W, Amaral MD, Rudolph S, Calfa G, Schuwald AM, Harteneck C, Inoue T, Pozzo-Miller L.

Hippocampus. 2013 Jan;23(1):40-52. doi: 10.1002/hipo.22052. Epub 2012 Jul 20.

PMID:
22815087
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

[Cellular and molecular effects of the antidepressant hyperforin on brain cells: Review of the literature].

Bouron A, Lorrain E.

Encephale. 2014 Apr;40(2):108-13. doi: 10.1016/j.encep.2013.03.004. Epub 2013 Jun 29. Review. French.

PMID:
23816060
[PubMed - indexed for MEDLINE]
4.

Role of hyperforin in the pharmacological activities of St. John's Wort.

Zanoli P.

CNS Drug Rev. 2004 Fall;10(3):203-18. Review.

PMID:
15492771
[PubMed - indexed for MEDLINE]
5.

The TRPC6 channel activator hyperforin induces the release of zinc and calcium from mitochondria.

Tu P, Gibon J, Bouron A.

J Neurochem. 2010 Jan;112(1):204-13. doi: 10.1111/j.1471-4159.2009.06446.x. Epub 2009 Oct 21.

PMID:
19845832
[PubMed - indexed for MEDLINE]
6.

Simple 2,4-diacylphloroglucinols as classic transient receptor potential-6 activators--identification of a novel pharmacophore.

Leuner K, Heiser JH, Derksen S, Mladenov MI, Fehske CJ, Schubert R, Gollasch M, Schneider G, Harteneck C, Chatterjee SS, Müller WE.

Mol Pharmacol. 2010 Mar;77(3):368-77. doi: 10.1124/mol.109.057513. Epub 2009 Dec 14.

PMID:
20008516
[PubMed - indexed for MEDLINE]
Free Article
7.

TRPC6 channel-mediated neurite outgrowth in PC12 cells and hippocampal neurons involves activation of RAS/MEK/ERK, PI3K, and CAMKIV signaling.

Heiser JH, Schuwald AM, Sillani G, Ye L, Müller WE, Leuner K.

J Neurochem. 2013 Nov;127(3):303-13. doi: 10.1111/jnc.12376. Epub 2013 Aug 19.

PMID:
23875811
[PubMed - indexed for MEDLINE]
8.

Hyperforin, the active component of St. John's wort, induces IL-8 expression in human intestinal epithelial cells via a MAPK-dependent, NF-kappaB-independent pathway.

Zhou C, Tabb MM, Sadatrafiei A, Grün F, Sun A, Blumberg B.

J Clin Immunol. 2004 Nov;24(6):623-36.

PMID:
15622447
[PubMed - indexed for MEDLINE]
9.

Protective effects of St. John's wort extract and its component hyperforin against cytokine-induced cytotoxicity in a pancreatic beta-cell line.

Menegazzi M, Novelli M, Beffy P, D'Aleo V, Tedeschi E, Lupi R, Zoratti E, Marchetti P, Suzuki H, Masiello P.

Int J Biochem Cell Biol. 2008;40(8):1509-21. doi: 10.1016/j.biocel.2007.11.019. Epub 2007 Dec 8.

PMID:
18226577
[PubMed - indexed for MEDLINE]
10.

Current St John's wort research from mode of action to clinical efficacy.

Müller WE.

Pharmacol Res. 2003 Feb;47(2):101-9. Review.

PMID:
12543057
[PubMed - indexed for MEDLINE]
11.

Hyperforin--antidepressant activity by a novel mechanism of action.

Müller WE, Singer A, Wonnemann M.

Pharmacopsychiatry. 2001 Jul;34 Suppl 1:S98-102.

PMID:
11518085
[PubMed - indexed for MEDLINE]
12.
13.

Hyperforin, a major antidepressant constituent of St. John's Wort, inhibits serotonin uptake by elevating free intracellular Na+1.

Singer A, Wonnemann M, Müller WE.

J Pharmacol Exp Ther. 1999 Sep;290(3):1363-8.

PMID:
10454515
[PubMed - indexed for MEDLINE]
Free Article
14.

Functional induction and de-induction of P-glycoprotein by St. John's wort and its ingredients in a human colon adenocarcinoma cell line.

Tian R, Koyabu N, Morimoto S, Shoyama Y, Ohtani H, Sawada Y.

Drug Metab Dispos. 2005 Apr;33(4):547-54. Epub 2005 Jan 7.

PMID:
15640377
[PubMed - indexed for MEDLINE]
Free Article
15.

Dual modulation of striatal acetylcholine release by hyperforin, a constituent of St. John's wort.

Buchholzer ML, Dvorak C, Chatterjee SS, Klein J.

J Pharmacol Exp Ther. 2002 May;301(2):714-9.

PMID:
11961077
[PubMed - indexed for MEDLINE]
Free Article
16.

NMDA receptor-antagonistic properties of hyperforin, a constituent of St. John's Wort.

Kumar V, Mdzinarishvili A, Kiewert C, Abbruscato T, Bickel U, van der Schyf CJ, Klein J.

J Pharmacol Sci. 2006 Sep;102(1):47-54. Epub 2006 Aug 26.

PMID:
16936454
[PubMed - indexed for MEDLINE]
Free Article
17.

Store-depletion and hyperforin activate distinct types of Ca(2+)-conducting channels in cortical neurons.

Gibon J, Tu P, Bouron A.

Cell Calcium. 2010 Jun;47(6):538-43. doi: 10.1016/j.ceca.2010.05.003. Epub 2010 Jun 2.

PMID:
20621761
[PubMed - indexed for MEDLINE]
18.

Hyperforin attenuates brain damage induced by transient middle cerebral artery occlusion (MCAO) in rats via inhibition of TRPC6 channels degradation.

Lin Y, Zhang JC, Fu J, Chen F, Wang J, Wu ZL, Yuan SY.

J Cereb Blood Flow Metab. 2013 Feb;33(2):253-62. doi: 10.1038/jcbfm.2012.164. Epub 2012 Nov 14.

PMID:
23149561
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Stimulation of hippocampal acetylcholine release by hyperforin, a constituent of St. John's Wort.

Kiewert C, Buchholzer ML, Hartmann J, Chatterjee SS, Klein J.

Neurosci Lett. 2004 Jul 8;364(3):195-8.

PMID:
15196674
[PubMed - indexed for MEDLINE]
20.

Hyperforin activates nonselective cation channels (NSCCs).

Treiber K, Singer A, Henke B, Müller WE.

Br J Pharmacol. 2005 May;145(1):75-83.

PMID:
15723093
[PubMed - indexed for MEDLINE]
Free PMC Article
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