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Results: 1 to 20 of 247

1.

Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants.

Li X, Tan YC, Poulose S, Olanow CW, Huang XY, Yue Z.

J Neurochem. 2007 Oct;103(1):238-47. Epub 2007 Jul 10.

PMID:
17623048
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

The R1441C mutation of LRRK2 disrupts GTP hydrolysis.

Lewis PA, Greggio E, Beilina A, Jain S, Baker A, Cookson MR.

Biochem Biophys Res Commun. 2007 Jun 8;357(3):668-71. Epub 2007 Apr 10.

PMID:
17442267
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity.

Guo L, Gandhi PN, Wang W, Petersen RB, Wilson-Delfosse AL, Chen SG.

Exp Cell Res. 2007 Oct 1;313(16):3658-70. Epub 2007 Jul 19.

PMID:
17706965
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1.

Stafa K, Trancikova A, Webber PJ, Glauser L, West AB, Moore DJ.

PLoS Genet. 2012;8(2):e1002526. doi: 10.1371/journal.pgen.1002526. Epub 2012 Feb 9.

PMID:
22363216
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2.

Biosa A, Trancikova A, Civiero L, Glauser L, Bubacco L, Greggio E, Moore DJ.

Hum Mol Genet. 2013 Mar 15;22(6):1140-56. doi: 10.1093/hmg/dds522. Epub 2012 Dec 13.

PMID:
23241358
[PubMed - indexed for MEDLINE]
Free Article
6.

Kinetic mechanistic studies of wild-type leucine-rich repeat kinase 2: characterization of the kinase and GTPase activities.

Liu M, Dobson B, Glicksman MA, Yue Z, Stein RL.

Biochemistry. 2010 Mar 9;49(9):2008-17. doi: 10.1021/bi901851y.

PMID:
20146535
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites.

Greggio E, Taymans JM, Zhen EY, Ryder J, Vancraenenbroeck R, Beilina A, Sun P, Deng J, Jaffe H, Baekelandt V, Merchant K, Cookson MR.

Biochem Biophys Res Commun. 2009 Nov 20;389(3):449-54. doi: 10.1016/j.bbrc.2009.08.163. Epub 2009 Sep 3.

PMID:
19733152
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

LRRK2 GTPase dysfunction in the pathogenesis of Parkinson's disease.

Xiong Y, Dawson VL, Dawson TM.

Biochem Soc Trans. 2012 Oct;40(5):1074-9. Review.

PMID:
22988868
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities.

Webber PJ, Smith AD, Sen S, Renfrow MB, Mobley JA, West AB.

J Mol Biol. 2011 Sep 9;412(1):94-110. doi: 10.1016/j.jmb.2011.07.033. Epub 2011 Jul 22.

PMID:
21806997
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization.

Sen S, Webber PJ, West AB.

J Biol Chem. 2009 Dec 25;284(52):36346-56. doi: 10.1074/jbc.M109.025437. Epub 2009 Oct 13.

PMID:
19826009
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease.

Ito G, Okai T, Fujino G, Takeda K, Ichijo H, Katada T, Iwatsubo T.

Biochemistry. 2007 Feb 6;46(5):1380-8.

PMID:
17260967
[PubMed - indexed for MEDLINE]
12.

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity.

West AB, Moore DJ, Choi C, Andrabi SA, Li X, Dikeman D, Biskup S, Zhang Z, Lim KL, Dawson VL, Dawson TM.

Hum Mol Genet. 2007 Jan 15;16(2):223-32. Epub 2007 Jan 2.

PMID:
17200152
[PubMed - indexed for MEDLINE]
Free Article
13.

Biochemical and molecular features of LRRK2 and its pathophysiological roles in Parkinson's disease.

Seol W.

BMB Rep. 2010 Apr;43(4):233-44. Review.

PMID:
20423607
[PubMed - indexed for MEDLINE]
Free Article
14.

LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding.

Taymans JM, Vancraenenbroeck R, Ollikainen P, Beilina A, Lobbestael E, De Maeyer M, Baekelandt V, Cookson MR.

PLoS One. 2011;6(8):e23207. doi: 10.1371/journal.pone.0023207. Epub 2011 Aug 12.

PMID:
21858031
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

The GTPase function of LRRK2.

Taymans JM.

Biochem Soc Trans. 2012 Oct;40(5):1063-9. Review.

PMID:
22988866
[PubMed - indexed for MEDLINE]
16.

The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules.

Gandhi PN, Wang X, Zhu X, Chen SG, Wilson-Delfosse AL.

J Neurosci Res. 2008 Jun;86(8):1711-20. doi: 10.1002/jnr.21622.

PMID:
18214993
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

The biology and pathobiology of LRRK2: implications for Parkinson's disease.

Moore DJ.

Parkinsonism Relat Disord. 2008;14 Suppl 2:S92-8. doi: 10.1016/j.parkreldis.2008.04.010. Epub 2008 Jul 7. Review.

PMID:
18602856
[PubMed - indexed for MEDLINE]
18.

Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease.

Li X, Wang QJ, Pan N, Lee S, Zhao Y, Chait BT, Yue Z.

PLoS One. 2011 Mar 1;6(3):e17153. doi: 10.1371/journal.pone.0017153. Erratum in: PLoS One.2011;6(7). doi: 10.1371/annotation/e66e7e90-9503-46b8-91f9-abe4d5056ba1.

PMID:
21390248
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

GTPase activity plays a key role in the pathobiology of LRRK2.

Xiong Y, Coombes CE, Kilaru A, Li X, Gitler AD, Bowers WJ, Dawson VL, Dawson TM, Moore DJ.

PLoS Genet. 2010 Apr 8;6(4):e1000902. doi: 10.1371/journal.pgen.1000902.

PMID:
20386743
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Leucine-rich repeat kinase 2: relevance to Parkinson's disease.

Guo L, Wang W, Chen SG.

Int J Biochem Cell Biol. 2006;38(9):1469-75. Epub 2006 Mar 2. Review.

PMID:
16600664
[PubMed - indexed for MEDLINE]

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