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Results: 1 to 20 of 97

1.

Phosphoinositide-dependent protein kinase-1 (PDK1)-independent activation of the protein kinase C substrate, protein kinase D.

Wood CD, Kelly AP, Matthews SA, Cantrell DA.

FEBS Lett. 2007 Jul 24;581(18):3494-8. Epub 2007 Jul 2.

PMID:
17617409
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Further evidence that 3-phosphoinositide-dependent protein kinase-1 (PDK1) is required for the stability and phosphorylation of protein kinase C (PKC) isoforms.

Balendran A, Hare GR, Kieloch A, Williams MR, Alessi DR.

FEBS Lett. 2000 Nov 10;484(3):217-23.

PMID:
11078882
[PubMed - indexed for MEDLINE]
Free Article
3.

In vivo role of the phosphate groove of PDK1 defined by knockin mutation.

Collins BJ, Deak M, Murray-Tait V, Storey KG, Alessi DR.

J Cell Sci. 2005 Nov 1;118(Pt 21):5023-34. Epub 2005 Oct 11.

PMID:
16219676
[PubMed - indexed for MEDLINE]
Free Article
4.

Protein kinase C(mu) regulation of the JNK pathway is triggered via phosphoinositide-dependent kinase 1 and protein kinase C(epsilon).

Brändlin I, Eiseler T, Salowsky R, Johannes FJ.

J Biol Chem. 2002 Nov 22;277(47):45451-7. Epub 2002 Sep 9.

PMID:
12223477
[PubMed - indexed for MEDLINE]
Free Article
5.

Inhibition of insulin-induced activation of Akt by a kinase-deficient mutant of the epsilon isozyme of protein kinase C.

Matsumoto M, Ogawa W, Hino Y, Furukawa K, Ono Y, Takahashi M, Ohba M, Kuroki T, Kasuga M.

J Biol Chem. 2001 Apr 27;276(17):14400-6. Epub 2001 Jan 22.

PMID:
11278835
[PubMed - indexed for MEDLINE]
Free Article
6.

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1.

Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ.

Science. 1998 Sep 25;281(5385):2042-5.

PMID:
9748166
[PubMed - indexed for MEDLINE]
Free Article
7.

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro.

Alessi DR, Kozlowski MT, Weng QP, Morrice N, Avruch J.

Curr Biol. 1998 Jan 15;8(2):69-81.

PMID:
9427642
[PubMed - indexed for MEDLINE]
Free Article
8.

Protein kinase C theta (PKCtheta)-dependent phosphorylation of PDK1 at Ser504 and Ser532 contributes to palmitate-induced insulin resistance.

Wang C, Liu M, Riojas RA, Xin X, Gao Z, Zeng R, Wu J, Dong LQ, Liu F.

J Biol Chem. 2009 Jan 23;284(4):2038-44. doi: 10.1074/jbc.M806336200. Epub 2008 Dec 1.

PMID:
19047061
[PubMed - indexed for MEDLINE]
Free Article
9.

A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1.

Balendran A, Biondi RM, Cheung PC, Casamayor A, Deak M, Alessi DR.

J Biol Chem. 2000 Jul 7;275(27):20806-13.

PMID:
10764742
[PubMed - indexed for MEDLINE]
Free Article
10.
12.

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells.

Williams MR, Arthur JS, Balendran A, van der Kaay J, Poli V, Cohen P, Alessi DR.

Curr Biol. 2000 Apr 20;10(8):439-48.

PMID:
10801415
[PubMed - indexed for MEDLINE]
Free Article
13.

Mechanism of phosphorylation of protein kinase B/Akt by a constitutively active 3-phosphoinositide-dependent protein kinase-1.

Wick MJ, Dong LQ, Riojas RA, Ramos FJ, Liu F.

J Biol Chem. 2000 Dec 22;275(51):40400-6.

PMID:
11006271
[PubMed - indexed for MEDLINE]
Free Article
14.

PDK1 in apical signaling endosomes participates in the rescue of the polarity complex atypical PKC by intermediate filaments in intestinal epithelia.

Mashukova A, Forteza R, Wald FA, Salas PJ.

Mol Biol Cell. 2012 May;23(9):1664-74. doi: 10.1091/mbc.E11-12-0988. Epub 2012 Mar 7.

PMID:
22398726
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Fused protein of deltaPKC activation loop and PDK1-interacting fragment (deltaAL-PIF) functions as a pseudosubstrate and an inhibitory molecule for PDK1 when expressed in cells.

Seki T, Irie N, Nakamura K, Sakaue H, Ogawa W, Kasuga M, Yamamoto H, Ohmori S, Saito N, Sakai N.

Genes Cells. 2006 Sep;11(9):1051-70.

PMID:
16923125
[PubMed - indexed for MEDLINE]
16.

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

Balendran A, Casamayor A, Deak M, Paterson A, Gaffney P, Currie R, Downes CP, Alessi DR.

Curr Biol. 1999 Apr 22;9(8):393-404.

PMID:
10226025
[PubMed - indexed for MEDLINE]
17.

Regulation of both PDK1 and the phosphorylation of PKC-zeta and -delta by a C-terminal PRK2 fragment.

Hodgkinson CP, Sale GJ.

Biochemistry. 2002 Jan 15;41(2):561-9.

PMID:
11781095
[PubMed - indexed for MEDLINE]
18.

Disruption of 3-phosphoinositide-dependent kinase 1 (PDK1) signaling by the anti-tumorigenic and anti-proliferative agent n-alpha-tosyl-l-phenylalanyl chloromethyl ketone.

Ballif BA, Shimamura A, Pae E, Blenis J.

J Biol Chem. 2001 Apr 13;276(15):12466-75. Epub 2001 Jan 18.

PMID:
11278584
[PubMed - indexed for MEDLINE]
Free Article
19.

PDK1-dependent activation of atypical PKC leads to degradation of the p21 tumour modifier protein.

Scott MT, Ingram A, Ball KL.

EMBO J. 2002 Dec 16;21(24):6771-80.

PMID:
12485998
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase.

Alessi DR, Deak M, Casamayor A, Caudwell FB, Morrice N, Norman DG, Gaffney P, Reese CB, MacDougall CN, Harbison D, Ashworth A, Bownes M.

Curr Biol. 1997 Oct 1;7(10):776-89.

PMID:
9368760
[PubMed - indexed for MEDLINE]
Free Article
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