Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Results: 1 to 20 of 139

1.

Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain.

Rojas RJ, Yohe ME, Gershburg S, Kawano T, Kozasa T, Sondek J.

J Biol Chem. 2007 Oct 5;282(40):29201-10. Epub 2007 Jul 2.

PMID:
17606614
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs.

Lutz S, Shankaranarayanan A, Coco C, Ridilla M, Nance MR, Vettel C, Baltus D, Evelyn CR, Neubig RR, Wieland T, Tesmer JJ.

Science. 2007 Dec 21;318(5858):1923-7.

PMID:
18096806
[PubMed - indexed for MEDLINE]
Free Article
3.

Galpha q allosterically activates and relieves autoinhibition of p63RhoGEF.

Shankaranarayanan A, Boguth CA, Lutz S, Vettel C, Uhlemann F, Aittaleb M, Wieland T, Tesmer JJ.

Cell Signal. 2010 Jul;22(7):1114-23. doi: 10.1016/j.cellsig.2010.03.006. Epub 2010 Mar 7.

PMID:
20214977
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

The RhoA-specific guanine nucleotide exchange factor p63RhoGEF binds to activated Galpha(16) and inhibits the canonical phospholipase Cbeta pathway.

Yeung WW, Wong YH.

Cell Signal. 2009 Aug;21(8):1317-25. doi: 10.1016/j.cellsig.2009.03.017. Epub 2009 Apr 5.

PMID:
19332116
[PubMed - indexed for MEDLINE]
5.

LARG links histamine-H1-receptor-activated Gq to Rho-GTPase-dependent signaling pathways.

Pfreimer M, Vatter P, Langer T, Wieland T, Gierschik P, Moepps B.

Cell Signal. 2012 Mar;24(3):652-63. doi: 10.1016/j.cellsig.2011.10.014. Epub 2011 Nov 10.

PMID:
22100544
[PubMed - indexed for MEDLINE]
6.

Trio's Rho-specific GEF domain is the missing Galpha q effector in C. elegans.

Williams SL, Lutz S, Charlie NK, Vettel C, Ailion M, Coco C, Tesmer JJ, Jorgensen EM, Wieland T, Miller KG.

Genes Dev. 2007 Nov 1;21(21):2731-46. Epub 2007 Oct 17.

PMID:
17942708
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

p63RhoGEF couples Gα(q/11)-mediated signaling to Ca2+ sensitization of vascular smooth muscle contractility.

Momotani K, Artamonov MV, Utepbergenov D, Derewenda U, Derewenda ZS, Somlyo AV.

Circ Res. 2011 Oct 14;109(9):993-1002. doi: 10.1161/CIRCRESAHA.111.248898. Epub 2011 Sep 1.

PMID:
21885830
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Galpha13 regulation of proto-Dbl signaling.

Vanni C, Mancini P, Ottaviano C, Ognibene M, Parodi A, Merello E, Russo C, Varesio L, Zheng Y, Torrisi MR, Eva A.

Cell Cycle. 2007 Aug 15;6(16):2058-70. Epub 2007 Jun 8.

PMID:
17721084
[PubMed - indexed for MEDLINE]
Free Article
9.

The DH and PH domains of Trio coordinately engage Rho GTPases for their efficient activation.

Chhatriwala MK, Betts L, Worthylake DK, Sondek J.

J Mol Biol. 2007 May 18;368(5):1307-20. Epub 2007 Feb 22.

PMID:
17391702
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Leukemia-associated Rho guanine nucleotide exchange factor promotes G alpha q-coupled activation of RhoA.

Booden MA, Siderovski DP, Der CJ.

Mol Cell Biol. 2002 Jun;22(12):4053-61.

PMID:
12024019
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Activation of p115-RhoGEF requires direct association of Gα13 and the Dbl homology domain.

Chen Z, Guo L, Hadas J, Gutowski S, Sprang SR, Sternweis PC.

J Biol Chem. 2012 Jul 20;287(30):25490-500. doi: 10.1074/jbc.M111.333716. Epub 2012 Jun 1.

PMID:
22661716
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Mechanisms of guanine nucleotide exchange and Rac-mediated signaling revealed by a dominant negative trio mutant.

Debreceni B, Gao Y, Guo F, Zhu K, Jia B, Zheng Y.

J Biol Chem. 2004 Jan 30;279(5):3777-86. Epub 2003 Nov 3.

PMID:
14597635
[PubMed - indexed for MEDLINE]
Free Article
13.

Plasma membrane association of p63 Rho guanine nucleotide exchange factor (p63RhoGEF) is mediated by palmitoylation and is required for basal activity in cells.

Aittaleb M, Nishimura A, Linder ME, Tesmer JJ.

J Biol Chem. 2011 Sep 30;286(39):34448-56. doi: 10.1074/jbc.M111.273342. Epub 2011 Aug 10.

PMID:
21832057
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

NMR structure and mutagenesis of the N-terminal Dbl homology domain of the nucleotide exchange factor Trio.

Liu X, Wang H, Eberstadt M, Schnuchel A, Olejniczak ET, Meadows RP, Schkeryantz JM, Janowick DA, Harlan JE, Harris EA, Staunton DE, Fesik SW.

Cell. 1998 Oct 16;95(2):269-77.

PMID:
9790533
[PubMed - indexed for MEDLINE]
Free Article
15.

Role of the C-terminal SH3 domain and N-terminal tyrosine phosphorylation in regulation of Tim and related Dbl-family proteins.

Yohe ME, Rossman K, Sondek J.

Biochemistry. 2008 Jul 1;47(26):6827-39. doi: 10.1021/bi702543p. Epub 2008 Jun 7.

PMID:
18537266
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor.

Kristelly R, Gao G, Tesmer JJ.

J Biol Chem. 2004 Nov 5;279(45):47352-62. Epub 2004 Aug 25.

PMID:
15331592
[PubMed - indexed for MEDLINE]
Free Article
17.

CCK activates RhoA and Rac1 differentially through Galpha13 and Galphaq in mouse pancreatic acini.

Sabbatini ME, Bi Y, Ji B, Ernst SA, Williams JA.

Am J Physiol Cell Physiol. 2010 Mar;298(3):C592-601. doi: 10.1152/ajpcell.00448.2009. Epub 2009 Nov 25.

PMID:
19940064
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Oncogenic Dbl, Cdc42, and p21-activated kinase form a ternary signaling intermediate through the minimum interactive domains.

Wang L, Zhu K, Zheng Y.

Biochemistry. 2004 Nov 23;43(46):14584-93.

PMID:
15544329
[PubMed - indexed for MEDLINE]
19.

Insights into the molecular activation mechanism of the RhoA-specific guanine nucleotide exchange factor, PDZRhoGEF.

Bielnicki JA, Shkumatov AV, Derewenda U, Somlyo AV, Svergun DI, Derewenda ZS.

J Biol Chem. 2011 Oct 7;286(40):35163-75. doi: 10.1074/jbc.M111.270918. Epub 2011 Aug 4.

PMID:
21816819
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Characterization of the GRK2 binding site of Galphaq.

Day PW, Tesmer JJ, Sterne-Marr R, Freeman LC, Benovic JL, Wedegaertner PB.

J Biol Chem. 2004 Dec 17;279(51):53643-52. Epub 2004 Oct 7.

PMID:
15471870
[PubMed - indexed for MEDLINE]
Free PMC Article

Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk