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Items: 1 to 20 of 112

1.

Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia.

Tan W, Wang Y, Gold B, Chen J, Dean M, Harrison PJ, Weinberger DR, Law AJ.

J Biol Chem. 2007 Aug 17;282(33):24343-51. Epub 2007 Jun 12.

2.

Molecular and cellular characterization of Neuregulin-1 type IV isoforms.

Shamir A, Buonanno A.

J Neurochem. 2010 Jun;113(5):1163-76. doi: 10.1111/j.1471-4159.2010.06677.x. Epub 2010 Mar 10.

3.

Effects of schizophrenia risk variation in the NRG1 gene on NRG1-IV splicing during fetal and early postnatal human neocortical development.

Paterson C, Wang Y, Kleinman JE, Law AJ.

Am J Psychiatry. 2014 Sep;171(9):979-89. doi: 10.1176/appi.ajp.2014.13111518.

4.

Lack of association to a NRG1 missense polymorphism in schizophrenia or bipolar disorder in a Costa Rican population.

Moon E, Rollins B, Mesén A, Sequeira A, Myers RM, Akil H, Watson SJ, Barchas J, Jones EG, Schatzberg A, Bunney WE, DeLisi LE, Byerley W, Vawter MP.

Schizophr Res. 2011 Sep;131(1-3):52-7. doi: 10.1016/j.schres.2011.06.024. Epub 2011 Jul 13.

5.

Schizophrenia-associated HapICE haplotype is associated with increased NRG1 type III expression and high nucleotide diversity.

Weickert CS, Tiwari Y, Schofield PR, Mowry BJ, Fullerton JM.

Transl Psychiatry. 2012 Apr 17;2:e104. doi: 10.1038/tp.2012.25.

6.

Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease.

Law AJ, Lipska BK, Weickert CS, Hyde TM, Straub RE, Hashimoto R, Harrison PJ, Kleinman JE, Weinberger DR.

Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6747-52. Epub 2006 Apr 17.

7.

Schizophrenia-risk variant rs6994992 in the neuregulin-1 gene on brain developmental trajectories in typically developing children.

Douet V, Chang L, Pritchett A, Lee K, Keating B, Bartsch H, Jernigan TL, Dale A, Akshoomoff N, Murray S, Bloss C, Kennedy DN, Amaral D, Gruen J, Kaufmann WE, Casey BJ, Sowell E, Ernst T.

Transl Psychiatry. 2014 May 27;4:e392. doi: 10.1038/tp.2014.41.

8.

Reversible overexpression of bace1-cleaved neuregulin-1 N-terminal fragment induces schizophrenia-like phenotypes in mice.

Luo X, He W, Hu X, Yan R.

Biol Psychiatry. 2014 Jul 15;76(2):120-7. doi: 10.1016/j.biopsych.2013.09.026. Epub 2013 Oct 5.

9.

The neuregulin 1 promoter polymorphism rs6994992 is not associated with chronic schizophrenia or neurocognition.

Crowley JJ, Keefe RS, Perkins DO, Stroup TS, Lieberman JA, Sullivan PF.

Am J Med Genet B Neuropsychiatr Genet. 2008 Oct 5;147B(7):1298-300. doi: 10.1002/ajmg.b.30727.

10.

Promotion of spermatogonial proliferation by neuregulin 1 in newt (Cynops pyrrhogaster) testis.

Oral O, Uchida I, Eto K, Nakayama Y, Nishimura O, Hirao Y, Ueda J, Tarui H, Agata K, Abé S.

Mech Dev. 2008 Sep-Oct;125(9-10):906-17. doi: 10.1016/j.mod.2008.06.004. Epub 2008 Jun 11.

11.

A 5' promoter region SNP in NRG1 is associated with schizophrenia risk and type III isoform expression.

Nicodemus KK, Law AJ, Luna A, Vakkalanka R, Straub RE, Kleinman JE, Weinberger DR.

Mol Psychiatry. 2009 Aug;14(8):741-3. doi: 10.1038/mp.2008.150. No abstract available.

12.

Analysis of a promoter polymorphism in the SMDF neuregulin 1 isoform in Schizophrenia.

Pedrosa E, Nolan KA, Stefanescu R, Herskovits P, Novak T, Zukov I, Stopkova P, Lachman HM.

Neuropsychobiology. 2009;59(4):205-12. doi: 10.1159/000223732. Epub 2009 Jun 10. Erratum in: Neuropsychobiology. 2009;60(2):72. Hershcovitz, Pnina [corrected to Herskovits, Pnina].

13.

Measurement and comparison of serum neuregulin 1 immunoreactivity in control subjects and patients with schizophrenia: an influence of its genetic polymorphism.

Shibuya M, Komi E, Wang R, Kato T, Watanabe Y, Sakai M, Ozaki M, Someya T, Nawa H.

J Neural Transm (Vienna). 2010 Jul;117(7):887-95. doi: 10.1007/s00702-010-0418-3. Epub 2010 Jun 5.

PMID:
20526724
14.

A neuregulin 1 transmembrane domain mutation causes imbalanced glutamatergic and dopaminergic receptor expression in mice.

Newell KA, Karl T, Huang XF.

Neuroscience. 2013 Sep 17;248:670-80. doi: 10.1016/j.neuroscience.2013.06.037. Epub 2013 Jun 27.

PMID:
23811072
15.

Disease-associated intronic variants in the ErbB4 gene are related to altered ErbB4 splice-variant expression in the brain in schizophrenia.

Law AJ, Kleinman JE, Weinberger DR, Weickert CS.

Hum Mol Genet. 2007 Jan 15;16(2):129-41. Epub 2006 Dec 12.

16.

Expression of ZNF804A in human brain and alterations in schizophrenia, bipolar disorder, and major depressive disorder: a novel transcript fetally regulated by the psychosis risk variant rs1344706.

Tao R, Cousijn H, Jaffe AE, Burnet PW, Edwards F, Eastwood SL, Shin JH, Lane TA, Walker MA, Maher BJ, Weinberger DR, Harrison PJ, Hyde TM, Kleinman JE.

JAMA Psychiatry. 2014 Oct;71(10):1112-20. doi: 10.1001/jamapsychiatry.2014.1079.

PMID:
25162540
17.

Alpha7 nicotinic acetylcholine receptor mRNA expression and binding in postmortem human brain are associated with genetic variation in neuregulin 1.

Mathew SV, Law AJ, Lipska BK, Dávila-García MI, Zamora ED, Mitkus SN, Vakkalanka R, Straub RE, Weinberger DR, Kleinman JE, Hyde TM.

Hum Mol Genet. 2007 Dec 1;16(23):2921-32. Epub 2007 Sep 20.

18.

Gene expression of neuregulin-1 isoforms in different brain regions of elderly schizophrenia patients.

Parlapani E, Schmitt A, Wirths O, Bauer M, Sommer C, Rueb U, Skowronek MH, Treutlein J, Petroianu GA, Rietschel M, Falkai P.

World J Biol Psychiatry. 2010 Mar;11(2 Pt 2):243-50. doi: 10.3109/15622970802022376.

PMID:
20218788
19.

Specific regulation of NRG1 isoform expression by neuronal activity.

Liu X, Bates R, Yin DM, Shen C, Wang F, Su N, Kirov SA, Luo Y, Wang JZ, Xiong WC, Mei L.

J Neurosci. 2011 Jun 8;31(23):8491-501. doi: 10.1523/JNEUROSCI.5317-10.2011.

20.

Additive effect of NRG1 and DISC1 genes on lateral ventricle enlargement in first episode schizophrenia.

Mata I, Perez-Iglesias R, Roiz-Santiañez R, Tordesillas-Gutierrez D, Gonzalez-Mandly A, Berja A, Vazquez-Barquero JL, Crespo-Facorro B.

Neuroimage. 2010 Nov 15;53(3):1016-22. doi: 10.1016/j.neuroimage.2009.11.010. Epub 2009 Nov 12.

PMID:
19913623
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