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Items: 1 to 20 of 250

1.

Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains.

Abbott DW, Yang Y, Hutti JE, Madhavarapu S, Kelliher MA, Cantley LC.

Mol Cell Biol. 2007 Sep;27(17):6012-25. Epub 2007 Jun 11.

2.

A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation.

Hasegawa M, Fujimoto Y, Lucas PC, Nakano H, Fukase K, Núñez G, Inohara N.

EMBO J. 2008 Jan 23;27(2):373-83. Epub 2007 Dec 13.

3.

NOD2 pathway activation by MDP or Mycobacterium tuberculosis infection involves the stable polyubiquitination of Rip2.

Yang Y, Yin C, Pandey A, Abbott D, Sassetti C, Kelliher MA.

J Biol Chem. 2007 Dec 14;282(50):36223-9. Epub 2007 Oct 18.

4.

The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO.

Abbott DW, Wilkins A, Asara JM, Cantley LC.

Curr Biol. 2004 Dec 29;14(24):2217-27.

5.

ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways.

Tao M, Scacheri PC, Marinis JM, Harhaj EW, Matesic LE, Abbott DW.

Curr Biol. 2009 Aug 11;19(15):1255-63. doi: 10.1016/j.cub.2009.06.038. Epub 2009 Jul 9.

6.

The c-Jun N-terminal kinase (JNK)-binding protein (JNKBP1) acts as a negative regulator of NOD2 protein signaling by inhibiting its oligomerization process.

Lecat A, Di Valentin E, Somja J, Jourdan S, Fillet M, Kufer TA, Habraken Y, Sadzot C, Louis E, Delvenne P, Piette J, Legrand-Poels S.

J Biol Chem. 2012 Aug 24;287(35):29213-26. doi: 10.1074/jbc.M112.355545. Epub 2012 Jun 14.

7.

Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains.

Emmerich CH, Ordureau A, Strickson S, Arthur JS, Pedrioli PG, Komander D, Cohen P.

Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15247-52. doi: 10.1073/pnas.1314715110. Epub 2013 Aug 28.

8.

TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains.

Kanayama A, Seth RB, Sun L, Ea CK, Hong M, Shaito A, Chiu YH, Deng L, Chen ZJ.

Mol Cell. 2004 Aug 27;15(4):535-48.

9.

E2 Polyubiquitin-conjugating enzyme Ubc13 in keratinocytes is essential for epidermal integrity.

Sayama K, Yamamoto M, Shirakata Y, Hanakawa Y, Hirakawa S, Dai X, Tohyama M, Tokumaru S, Shin MS, Sakurai H, Akira S, Hashimoto K.

J Biol Chem. 2010 Sep 24;285(39):30042-9. doi: 10.1074/jbc.M110.106484. Epub 2010 Jul 27.

10.

The coiled-coil domain of TRAF6 is essential for its auto-ubiquitination.

Yang K, Zhu J, Sun S, Tang Y, Zhang B, Diao L, Wang C.

Biochem Biophys Res Commun. 2004 Nov 5;324(1):432-9.

PMID:
15465037
11.

Activation of NOD2-mediated intestinal pathway in a pediatric population with Crohn's disease.

Negroni A, Stronati L, Pierdomenico M, Tirindelli D, Di Nardo G, Mancini V, Maiella G, Cucchiara S.

Inflamm Bowel Dis. 2009 Aug;15(8):1145-54. doi: 10.1002/ibd.20907.

PMID:
19266573
12.

Reciprocal cross-talk between Nod2 and TAK1 signaling pathways.

Chen CM, Gong Y, Zhang M, Chen JJ.

J Biol Chem. 2004 Jun 11;279(24):25876-82. Epub 2004 Apr 9.

13.

Pro-angiogenic activity of TLRs and NLRs: a novel link between gut microbiota and intestinal angiogenesis.

Schirbel A, Kessler S, Rieder F, West G, Rebert N, Asosingh K, McDonald C, Fiocchi C.

Gastroenterology. 2013 Mar;144(3):613-623.e9. doi: 10.1053/j.gastro.2012.11.005. Epub 2012 Nov 10.

14.

A genome-wide siRNA screen reveals positive and negative regulators of the NOD2 and NF-κB signaling pathways.

Warner N, Burberry A, Franchi L, Kim YG, McDonald C, Sartor MA, Núñez G.

Sci Signal. 2013 Jan 15;6(258):rs3. doi: 10.1126/scisignal.2003305.

15.

Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation.

Conze DB, Wu CJ, Thomas JA, Landstrom A, Ashwell JD.

Mol Cell Biol. 2008 May;28(10):3538-47. doi: 10.1128/MCB.02098-07. Epub 2008 Mar 17.

16.

Toll-like receptor-induced granulocyte-macrophage colony-stimulating factor secretion is impaired in Crohn's disease by nucleotide oligomerization domain 2-dependent and -independent pathways.

Brosbøl-Ravnborg A, Hvas CL, Agnholt J, Dahlerup JF, Vind I, Till A, Rosenstiel P, Höllsberg P.

Clin Exp Immunol. 2009 Mar;155(3):487-95. doi: 10.1111/j.1365-2249.2008.03850.x. Epub 2008 Dec 15.

17.

NOD2 downregulates colonic inflammation by IRF4-mediated inhibition of K63-linked polyubiquitination of RICK and TRAF6.

Watanabe T, Asano N, Meng G, Yamashita K, Arai Y, Sakurai T, Kudo M, Fuss IJ, Kitani A, Shimosegawa T, Chiba T, Strober W.

Mucosal Immunol. 2014 Nov;7(6):1312-25. doi: 10.1038/mi.2014.19. Epub 2014 Mar 26.

18.

Expression of TRAF6 and pro-inflammatory cytokines through activation of TLR2, TLR4, NOD1, and NOD2 in human periodontal ligament fibroblasts.

Tang L, Zhou XD, Wang Q, Zhang L, Wang Y, Li XY, Huang DM.

Arch Oral Biol. 2011 Oct;56(10):1064-72. doi: 10.1016/j.archoralbio.2011.02.020. Epub 2011 Mar 31.

PMID:
21457942
19.

Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation.

Lamothe B, Besse A, Campos AD, Webster WK, Wu H, Darnay BG.

J Biol Chem. 2007 Feb 9;282(6):4102-12. Epub 2006 Nov 29.

20.

IRAK-1-mediated negative regulation of Toll-like receptor signaling through proteasome-dependent downregulation of TRAF6.

Muroi M, Tanamoto K.

Biochim Biophys Acta. 2012 Feb;1823(2):255-63. doi: 10.1016/j.bbamcr.2011.10.003. Epub 2011 Oct 18.

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