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Results: 1 to 20 of 816

1.

Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer.

Roberts PJ, Der CJ.

Oncogene. 2007 May 14;26(22):3291-310. Review.

PMID:
17496923
[PubMed - indexed for MEDLINE]
2.

Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance.

McCubrey JA, Steelman LS, Abrams SL, Lee JT, Chang F, Bertrand FE, Navolanic PM, Terrian DM, Franklin RA, D'Assoro AB, Salisbury JL, Mazzarino MC, Stivala F, Libra M.

Adv Enzyme Regul. 2006;46:249-79. Epub 2006 Jul 18.

PMID:
16854453
[PubMed - indexed for MEDLINE]
3.

Advances in targeting the Ras/Raf/MEK/Erk mitogen-activated protein kinase cascade with MEK inhibitors for cancer therapy.

Friday BB, Adjei AA.

Clin Cancer Res. 2008 Jan 15;14(2):342-6. doi: 10.1158/1078-0432.CCR-07-4790.

PMID:
18223206
[PubMed - indexed for MEDLINE]
Free Article
4.

Targeting the Raf/MEK/ERK pathway with small-molecule inhibitors.

McCubrey JA, Milella M, Tafuri A, Martelli AM, Lunghi P, Bonati A, Cervello M, Lee JT, Steelman LS.

Curr Opin Investig Drugs. 2008 Jun;9(6):614-30.

PMID:
18516761
[PubMed - indexed for MEDLINE]
5.

Targeting the RAF-MEK-ERK pathway in cancer therapy.

Montagut C, Settleman J.

Cancer Lett. 2009 Oct 8;283(2):125-34. doi: 10.1016/j.canlet.2009.01.022. Epub 2009 Feb 12. Review.

PMID:
19217204
[PubMed - indexed for MEDLINE]
6.

MEK inhibitors: a therapeutic approach to targeting the Ras-MAP kinase pathway in tumors.

Sebolt-Leopold JS.

Curr Pharm Des. 2004;10(16):1907-14. Review.

PMID:
15180527
[PubMed - indexed for MEDLINE]
7.

Histamine H1 receptor antagonist blocks histamine-induced proinflammatory cytokine production through inhibition of Ca2+-dependent protein kinase C, Raf/MEK/ERK and IKK/I kappa B/NF-kappa B signal cascades.

Matsubara M, Tamura T, Ohmori K, Hasegawa K.

Biochem Pharmacol. 2005 Feb 1;69(3):433-49. Epub 2004 Dec 9.

PMID:
15652235
[PubMed - indexed for MEDLINE]
8.

Raf: a strategic target for therapeutic development against cancer.

Beeram M, Patnaik A, Rowinsky EK.

J Clin Oncol. 2005 Sep 20;23(27):6771-90. Review.

PMID:
16170185
[PubMed - indexed for MEDLINE]
9.

Pharmacologic inhibition of RAF-->MEK-->ERK signaling elicits pancreatic cancer cell cycle arrest through induced expression of p27Kip1.

Gysin S, Lee SH, Dean NM, McMahon M.

Cancer Res. 2005 Jun 1;65(11):4870-80.

PMID:
15930308
[PubMed - indexed for MEDLINE]
Free Article
10.

Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.

Steelman LS, Franklin RA, Abrams SL, Chappell W, Kempf CR, Bäsecke J, Stivala F, Donia M, Fagone P, Nicoletti F, Libra M, Ruvolo P, Ruvolo V, Evangelisti C, Martelli AM, McCubrey JA.

Leukemia. 2011 Jul;25(7):1080-94. doi: 10.1038/leu.2011.66. Epub 2011 Apr 15. Review.

PMID:
21494257
[PubMed - indexed for MEDLINE]
11.

Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5.

Liu L, Cao Y, Chen C, Zhang X, McNabola A, Wilkie D, Wilhelm S, Lynch M, Carter C.

Cancer Res. 2006 Dec 15;66(24):11851-8.

PMID:
17178882
[PubMed - indexed for MEDLINE]
Free Article
12.

Targeting mitogen-activated protein kinase kinase (MEK) in solid tumors.

Duffy A, Kummar S.

Target Oncol. 2009 Dec;4(4):267-73. doi: 10.1007/s11523-009-0125-x. Epub 2009 Nov 10. Review.

PMID:
19899001
[PubMed - indexed for MEDLINE]
13.

Activation and role of MAP kinase-dependent pathways in retinal pigment epithelial cells: ERK and RPE cell proliferation.

Hecquet C, Lefevre G, Valtink M, Engelmann K, Mascarelli F.

Invest Ophthalmol Vis Sci. 2002 Sep;43(9):3091-8.

PMID:
12202534
[PubMed - indexed for MEDLINE]
Free Article
14.

Targeting Raf/MEK/ERK pathway in pituitary adenomas.

Suojun Z, Feng W, Dongsheng G, Ting L.

Eur J Cancer. 2012 Feb;48(3):389-95. doi: 10.1016/j.ejca.2011.11.002. Epub 2011 Nov 24. Review.

PMID:
22119203
[PubMed - indexed for MEDLINE]
15.

Flagellin and lipopolysaccharide stimulate the MEK-ERK signaling pathway in chicken heterophils through differential activation of the small GTPases, Ras and Rap1.

Kogut MH, Genovese KJ, He H.

Mol Immunol. 2007 Mar;44(7):1729-36. Epub 2006 Oct 12.

PMID:
17045653
[PubMed - indexed for MEDLINE]
16.

Characterization of a novel mitogen-activated protein kinase kinase 1/2 inhibitor with a unique mechanism of action for cancer therapy.

Daouti S, Wang H, Li WH, Higgins B, Kolinsky K, Packman K, Specian A Jr, Kong N, Huby N, Wen Y, Xiang Q, Podlaski FJ, He Y, Fotouhi N, Heimbrook D, Niu H.

Cancer Res. 2009 Mar 1;69(5):1924-32. doi: 10.1158/0008-5472.CAN-08-2627. Epub 2009 Feb 24.

PMID:
19244124
[PubMed - indexed for MEDLINE]
Free Article
17.

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.

Hatzivassiliou G, Song K, Yen I, Brandhuber BJ, Anderson DJ, Alvarado R, Ludlam MJ, Stokoe D, Gloor SL, Vigers G, Morales T, Aliagas I, Liu B, Sideris S, Hoeflich KP, Jaiswal BS, Seshagiri S, Koeppen H, Belvin M, Friedman LS, Malek S.

Nature. 2010 Mar 18;464(7287):431-5. doi: 10.1038/nature08833. Epub 2010 Feb 3.

PMID:
20130576
[PubMed - indexed for MEDLINE]
18.

Activation of the RAF/mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase pathway mediates apoptosis induced by chelerythrine in osteosarcoma.

Yang R, Piperdi S, Gorlick R.

Clin Cancer Res. 2008 Oct 15;14(20):6396-404. doi: 10.1158/1078-0432.CCR-07-5113.

PMID:
18927278
[PubMed - indexed for MEDLINE]
Free Article
19.

Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway.

Gollob JA, Wilhelm S, Carter C, Kelley SL.

Semin Oncol. 2006 Aug;33(4):392-406. Review.

PMID:
16890795
[PubMed - indexed for MEDLINE]
20.

Cell type-specific importance of ras-c-raf complex association rate constants for MAPK signaling.

Kiel C, Serrano L.

Sci Signal. 2009 Jul 28;2(81):ra38. doi: 10.1126/scisignal.2000397.

PMID:
19638615
[PubMed - indexed for MEDLINE]
Free Article

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