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Complex translational regulation of BACE1 involves upstream AUGs and stimulatory elements within the 5' untranslated region.

Mihailovich M, Thermann R, Grohovaz F, Hentze MW, Zacchetti D.

Nucleic Acids Res. 2007;35(9):2975-85. Epub 2007 Apr 16.


Leaky scanning and reinitiation regulate BACE1 gene expression.

Zhou W, Song W.

Mol Cell Biol. 2006 May;26(9):3353-64.


Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region.

Lammich S, Schöbel S, Zimmer AK, Lichtenthaler SF, Haass C.

EMBO Rep. 2004 Jun;5(6):620-5. Epub 2004 May 28.


Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's disease.

Rossner S, Sastre M, Bourne K, Lichtenthaler SF.

Prog Neurobiol. 2006 Jun;79(2):95-111. Epub 2006 Aug 14. Review.


Expression of the anti-amyloidogenic secretase ADAM10 is suppressed by its 5'-untranslated region.

Lammich S, Buell D, Zilow S, Ludwig AK, Nuscher B, Lichtenthaler SF, Prinzen C, Fahrenholz F, Haass C.

J Biol Chem. 2010 May 21;285(21):15753-60. doi: 10.1074/jbc.M110.110742. Epub 2010 Mar 26.


MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1.

Boissonneault V, Plante I, Rivest S, Provost P.

J Biol Chem. 2009 Jan 23;284(4):1971-81. doi: 10.1074/jbc.M807530200. Epub 2008 Nov 5.


DNA methylation of the 5'-untranslated region at +298 and +351 represses BACE1 expression in mouse BV-2 microglial cells.

Byun CJ, Seo J, Jo SA, Park YJ, Klug M, Rehli M, Park MH, Jo I.

Biochem Biophys Res Commun. 2012 Jan 6;417(1):387-92. doi: 10.1016/j.bbrc.2011.11.123. Epub 2011 Dec 6.


Identification of a cis-acting element involved in the regulation of BACE1 mRNA alternative splicing.

Mowrer KR, Wolfe MS.

J Neurochem. 2009 May;109(4):1008-16. doi: 10.1111/j.1471-4159.2009.06026.x. Epub 2009 Mar 3.


Unified translation repression mechanism for microRNAs and upstream AUGs.

Ajay SS, Athey BD, Lee I.

BMC Genomics. 2010 Mar 5;11:155. doi: 10.1186/1471-2164-11-155.


Promotion of BACE1 mRNA alternative splicing reduces amyloid beta-peptide production.

Mowrer KR, Wolfe MS.

J Biol Chem. 2008 Jul 4;283(27):18694-701. doi: 10.1074/jbc.M801322200. Epub 2008 May 8.


APP and BACE1 miRNA genetic variability has no major role in risk for Alzheimer disease.

Bettens K, Brouwers N, Engelborghs S, Van Miegroet H, De Deyn PP, Theuns J, Sleegers K, Van Broeckhoven C.

Hum Mutat. 2009 Aug;30(8):1207-13. doi: 10.1002/humu.21027.


Translational control of BACE1 may go awry in Alzheimer's disease.

Wong PC.

Neuron. 2008 Dec 26;60(6):941-3. doi: 10.1016/j.neuron.2008.12.010.


Translational regulation of BACE-1 expression in neuronal and non-neuronal cells.

De Pietri Tonelli D, Mihailovich M, Di Cesare A, Codazzi F, Grohovaz F, Zacchetti D.

Nucleic Acids Res. 2004 Mar 19;32(5):1808-17. Print 2004.


Differential utilization of upstream AUGs in the beta-secretase mRNA suggests that a shunting mechanism regulates translation.

Rogers GW Jr, Edelman GM, Mauro VP.

Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2794-9. Epub 2004 Feb 23.


In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.

Sankaranarayanan S, Price EA, Wu G, Crouthamel MC, Shi XP, Tugusheva K, Tyler KX, Kahana J, Ellis J, Jin L, Steele T, Stachel S, Coburn C, Simon AJ.

J Pharmacol Exp Ther. 2008 Mar;324(3):957-69. Epub 2007 Dec 21.


NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42.

Buggia-Prevot V, Sevalle J, Rossner S, Checler F.

J Biol Chem. 2008 Apr 11;283(15):10037-47. doi: 10.1074/jbc.M706579200. Epub 2008 Feb 8.


Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression.

Hébert SS, Horré K, Nicolaï L, Papadopoulou AS, Mandemakers W, Silahtaroglu AN, Kauppinen S, Delacourte A, De Strooper B.

Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6415-20. doi: 10.1073/pnas.0710263105. Epub 2008 Apr 23.

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