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Results: 1 to 20 of 149

1.

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons.

Nagai M, Re DB, Nagata T, Chalazonitis A, Jessell TM, Wichterle H, Przedborski S.

Nat Neurosci. 2007 May;10(5):615-22. Epub 2007 Apr 15.

PMID:
17435755
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells.

Marchetto MC, Muotri AR, Mu Y, Smith AM, Cezar GG, Gage FH.

Cell Stem Cell. 2008 Dec 4;3(6):649-57. doi: 10.1016/j.stem.2008.10.001.

PMID:
19041781
[PubMed - indexed for MEDLINE]
Free Article
3.

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons.

Haidet-Phillips AM, Hester ME, Miranda CJ, Meyer K, Braun L, Frakes A, Song S, Likhite S, Murtha MJ, Foust KD, Rao M, Eagle A, Kammesheidt A, Christensen A, Mendell JR, Burghes AH, Kaspar BK.

Nat Biotechnol. 2011 Aug 10;29(9):824-8. doi: 10.1038/nbt.1957.

PMID:
21832997
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Wild-type but not mutant SOD1 transgenic astrocytes promote the efficient generation of motor neuron progenitors from mouse embryonic stem cells.

Christou YA, Ohyama K, Placzek M, Monk PN, Shaw PJ.

BMC Neurosci. 2013 Oct 17;14:126. doi: 10.1186/1471-2202-14-126.

PMID:
24134124
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Mutant SOD1-expressing astrocytes release toxic factors that trigger motoneuron death by inducing hyperexcitability.

Fritz E, Izaurieta P, Weiss A, Mir FR, Rojas P, Gonzalez D, Rojas F, Brown RH Jr, Madrid R, van Zundert B.

J Neurophysiol. 2013 Jun;109(11):2803-14. doi: 10.1152/jn.00500.2012. Epub 2013 Mar 13.

PMID:
23486205
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Mutant copper-zinc superoxide dismutase (SOD1) induces protein secretion pathway alterations and exosome release in astrocytes: implications for disease spreading and motor neuron pathology in amyotrophic lateral sclerosis.

Basso M, Pozzi S, Tortarolo M, Fiordaliso F, Bisighini C, Pasetto L, Spaltro G, Lidonnici D, Gensano F, Battaglia E, Bendotti C, Bonetto V.

J Biol Chem. 2013 May 31;288(22):15699-711. doi: 10.1074/jbc.M112.425066. Epub 2013 Apr 16.

PMID:
23592792
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Astrocytic production of nerve growth factor in motor neuron apoptosis: implications for amyotrophic lateral sclerosis.

Pehar M, Cassina P, Vargas MR, Castellanos R, Viera L, Beckman JS, Estévez AG, Barbeito L.

J Neurochem. 2004 Apr;89(2):464-73.

PMID:
15056289
[PubMed - indexed for MEDLINE]
8.

Modulation of astrocytic mitochondrial function by dichloroacetate improves survival and motor performance in inherited amyotrophic lateral sclerosis.

Miquel E, Cassina A, Martínez-Palma L, Bolatto C, Trías E, Gandelman M, Radi R, Barbeito L, Cassina P.

PLoS One. 2012;7(4):e34776. doi: 10.1371/journal.pone.0034776. Epub 2012 Apr 3.

PMID:
22509356
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Amyotrophic lateral sclerosis model derived from human embryonic stem cells overexpressing mutant superoxide dismutase 1.

Wada T, Goparaju SK, Tooi N, Inoue H, Takahashi R, Nakatsuji N, Aiba K.

Stem Cells Transl Med. 2012 May;1(5):396-402. doi: 10.5966/sctm.2011-0061. Epub 2012 May 8.

PMID:
23197818
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Transcriptional profile of primary astrocytes expressing ALS-linked mutant SOD1.

Vargas MR, Pehar M, Díaz-Amarilla PJ, Beckman JS, Barbeito L.

J Neurosci Res. 2008 Dec;86(16):3515-25. doi: 10.1002/jnr.21797.

PMID:
18683239
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Hsp27 and Hsp70 administered in combination have a potent protective effect against FALS-associated SOD1-mutant-induced cell death in mammalian neuronal cells.

Patel YJ, Payne Smith MD, de Belleroche J, Latchman DS.

Brain Res Mol Brain Res. 2005 Apr 4;134(2):256-74. Epub 2004 Dec 15.

PMID:
15836922
[PubMed - indexed for MEDLINE]
13.

GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS.

Suzuki M, McHugh J, Tork C, Shelley B, Klein SM, Aebischer P, Svendsen CN.

PLoS One. 2007 Aug 1;2(8):e689.

PMID:
17668067
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Spinal inhibitory interneuron pathology follows motor neuron degeneration independent of glial mutant superoxide dismutase 1 expression in SOD1-ALS mice.

Hossaini M, Cardona Cano S, van Dis V, Haasdijk ED, Hoogenraad CC, Holstege JC, Jaarsma D.

J Neuropathol Exp Neurol. 2011 Aug;70(8):662-77. doi: 10.1097/NEN.0b013e31822581ac.

PMID:
21760539
[PubMed - indexed for MEDLINE]
15.

Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model.

Di Giorgio FP, Carrasco MA, Siao MC, Maniatis T, Eggan K.

Nat Neurosci. 2007 May;10(5):608-14. Epub 2007 Apr 15.

PMID:
17435754
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Autophagy activation and neuroprotection by progesterone in the G93A-SOD1 transgenic mouse model of amyotrophic lateral sclerosis.

Kim J, Kim TY, Cho KS, Kim HN, Koh JY.

Neurobiol Dis. 2013 Nov;59:80-5. doi: 10.1016/j.nbd.2013.07.011. Epub 2013 Jul 26.

PMID:
23891729
[PubMed - indexed for MEDLINE]
17.

Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice.

Jaarsma D, Teuling E, Haasdijk ED, De Zeeuw CI, Hoogenraad CC.

J Neurosci. 2008 Feb 27;28(9):2075-88. doi: 10.1523/JNEUROSCI.5258-07.2008.

PMID:
18305242
[PubMed - indexed for MEDLINE]
Free Article
18.

Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis.

Vargas MR, Johnson DA, Sirkis DW, Messing A, Johnson JA.

J Neurosci. 2008 Dec 10;28(50):13574-81. doi: 10.1523/JNEUROSCI.4099-08.2008.

PMID:
19074031
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Nuclear localization of human SOD1 and mutant SOD1-specific disruption of survival motor neuron protein complex in transgenic amyotrophic lateral sclerosis mice.

Gertz B, Wong M, Martin LJ.

J Neuropathol Exp Neurol. 2012 Feb;71(2):162-77. doi: 10.1097/NEN.0b013e318244b635.

PMID:
22249462
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Dysregulation of astrocyte-motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis.

Ferraiuolo L, Higginbottom A, Heath PR, Barber S, Greenald D, Kirby J, Shaw PJ.

Brain. 2011 Sep;134(Pt 9):2627-41. doi: 10.1093/brain/awr193.

PMID:
21908873
[PubMed - indexed for MEDLINE]
Free PMC Article

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