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Results: 1 to 20 of 99

Similar articles for PubMed (Select 17386266)

1.

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.

Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA, Sabatini DM.

Mol Cell. 2007 Mar 23;25(6):903-15.

2.

PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex.

Fonseca BD, Smith EM, Lee VH, MacKintosh C, Proud CG.

J Biol Chem. 2007 Aug 24;282(34):24514-24. Epub 2007 Jun 29.

3.

RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells.

Gordon BS, Kazi AA, Coleman CS, Dennis MD, Chau V, Jefferson LS, Kimball SR.

Cell Signal. 2014 Mar;26(3):461-7. doi: 10.1016/j.cellsig.2013.11.035. Epub 2013 Dec 3.

4.

Alcohol and PRAS40 knockdown decrease mTOR activity and protein synthesis via AMPK signaling and changes in mTORC1 interaction.

Hong-Brown LQ, Brown CR, Kazi AA, Huber DS, Pruznak AM, Lang CH.

J Cell Biochem. 2010 Apr 15;109(6):1172-84. doi: 10.1002/jcb.22496.

5.

The mechanism of insulin-stimulated 4E-BP protein binding to mammalian target of rapamycin (mTOR) complex 1 and its contribution to mTOR complex 1 signaling.

Rapley J, Oshiro N, Ortiz-Vega S, Avruch J.

J Biol Chem. 2011 Nov 4;286(44):38043-53. doi: 10.1074/jbc.M111.245449. Epub 2011 Sep 13.

6.

Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1.

Nascimento EB, Snel M, Guigas B, van der Zon GC, Kriek J, Maassen JA, Jazet IM, Diamant M, Ouwens DM.

Cell Signal. 2010 Jun;22(6):961-7. doi: 10.1016/j.cellsig.2010.02.002. Epub 2010 Feb 6.

PMID:
20138985
7.

Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation.

Wang L, Harris TE, Lawrence JC Jr.

J Biol Chem. 2008 Jun 6;283(23):15619-27. doi: 10.1074/jbc.M800723200. Epub 2008 Mar 27.

8.

Hydrogen peroxide impairs insulin-stimulated assembly of mTORC1.

Zhang L, Kimball SR, Jefferson LS, Shenberger JS.

Free Radic Biol Med. 2009 Jun 1;46(11):1500-9. doi: 10.1016/j.freeradbiomed.2009.03.001. Epub 2009 Mar 10.

9.

The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1.

Oshiro N, Takahashi R, Yoshino K, Tanimura K, Nakashima A, Eguchi S, Miyamoto T, Hara K, Takehana K, Avruch J, Kikkawa U, Yonezawa K.

J Biol Chem. 2007 Jul 13;282(28):20329-39. Epub 2007 May 21.

10.

PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding.

Wang L, Harris TE, Roth RA, Lawrence JC Jr.

J Biol Chem. 2007 Jul 6;282(27):20036-44. Epub 2007 May 17.

11.

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40.

Vander Haar E, Lee SI, Bandhakavi S, Griffin TJ, Kim DH.

Nat Cell Biol. 2007 Mar;9(3):316-23. Epub 2007 Feb 4.

PMID:
17277771
12.

Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein.

Sato T, Nakashima A, Guo L, Tamanoi F.

J Biol Chem. 2009 May 8;284(19):12783-91. doi: 10.1074/jbc.M809207200. Epub 2009 Mar 19.

13.

PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis.

Thedieck K, Polak P, Kim ML, Molle KD, Cohen A, Jenö P, Arrieumerlou C, Hall MN.

PLoS One. 2007 Nov 21;2(11):e1217.

14.

PRAS40: target or modulator of mTORC1 signalling and insulin action?

Nascimento EB, Ouwens DM.

Arch Physiol Biochem. 2009 Oct;115(4):163-75. doi: 10.1080/13813450902988580. Review.

PMID:
19480563
15.
16.

cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity.

Xie J, Ponuwei GA, Moore CE, Willars GB, Tee AR, Herbert TP.

Cell Signal. 2011 Dec;23(12):1927-35. doi: 10.1016/j.cellsig.2011.06.025. Epub 2011 Jul 6.

17.

Mechanisms involved in the coordinate regulation of mTORC1 by insulin and amino acids.

Dennis MD, Baum JI, Kimball SR, Jefferson LS.

J Biol Chem. 2011 Mar 11;286(10):8287-96. doi: 10.1074/jbc.M110.209171. Epub 2011 Jan 14.

18.

Mammalian target of rapamycin complex 1-mediated phosphorylation of eukaryotic initiation factor 4E-binding protein 1 requires multiple protein-protein interactions for substrate recognition.

Dunlop EA, Dodd KM, Seymour LA, Tee AR.

Cell Signal. 2009 Jul;21(7):1073-84. doi: 10.1016/j.cellsig.2009.02.024. Epub 2009 Mar 9.

PMID:
19272448
19.

The binding of PRAS40 to 14-3-3 proteins is not required for activation of mTORC1 signalling by phorbol esters/ERK.

Fonseca BD, Lee VH, Proud CG.

Biochem J. 2008 Apr 1;411(1):141-9. doi: 10.1042/BJ20071001.

PMID:
18215133
20.

Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia.

Wolff NC, Vega-Rubin-de-Celis S, Xie XJ, Castrillon DH, Kabbani W, Brugarolas J.

Mol Cell Biol. 2011 May;31(9):1870-84. doi: 10.1128/MCB.01393-10. Epub 2011 Mar 7.

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