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Results: 1 to 20 of 148

1.

Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation.

Sontag E, Nunbhakdi-Craig V, Sontag JM, Diaz-Arrastia R, Ogris E, Dayal S, Lentz SR, Arning E, Bottiglieri T.

J Neurosci. 2007 Mar 14;27(11):2751-9.

PMID:
17360897
[PubMed - indexed for MEDLINE]
Free Article
2.

Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis.

Sontag E, Hladik C, Montgomery L, Luangpirom A, Mudrak I, Ogris E, White CL 3rd.

J Neuropathol Exp Neurol. 2004 Oct;63(10):1080-91.

PMID:
15535135
[PubMed - indexed for MEDLINE]
3.

Folate deficiency induces in vitro and mouse brain region-specific downregulation of leucine carboxyl methyltransferase-1 and protein phosphatase 2A B(alpha) subunit expression that correlate with enhanced tau phosphorylation.

Sontag JM, Nunbhakdi-Craig V, Montgomery L, Arning E, Bottiglieri T, Sontag E.

J Neurosci. 2008 Nov 5;28(45):11477-87. doi: 10.1523/JNEUROSCI.2816-08.2008.

PMID:
18987184
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A.

Zhou XW, Gustafsson JA, Tanila H, Bjorkdahl C, Liu R, Winblad B, Pei JJ.

Neurobiol Dis. 2008 Sep;31(3):386-94. doi: 10.1016/j.nbd.2008.05.013. Epub 2008 Jul 23.

PMID:
18586097
[PubMed - indexed for MEDLINE]
5.

Acute administration of L-DOPA induces changes in methylation metabolites, reduced protein phosphatase 2A methylation, and hyperphosphorylation of Tau protein in mouse brain.

Bottiglieri T, Arning E, Wasek B, Nunbhakdi-Craig V, Sontag JM, Sontag E.

J Neurosci. 2012 Jul 4;32(27):9173-81. doi: 10.1523/JNEUROSCI.0125-12.2012.

PMID:
22764226
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Protein phosphatase 2A methylation: a link between elevated plasma homocysteine and Alzheimer's Disease.

Vafai SB, Stock JB.

FEBS Lett. 2002 May 8;518(1-3):1-4.

PMID:
11997007
[PubMed - indexed for MEDLINE]
Free Article
7.

Methotrexate decreases PP2A methylation and increases tau phosphorylation in neuron.

Yoon SY, Choi HI, Choi JE, Sul CA, Choi JM, Kim DH.

Biochem Biophys Res Commun. 2007 Nov 23;363(3):811-6. Epub 2007 Sep 24.

PMID:
17904102
[PubMed - indexed for MEDLINE]
8.

Modeling Alzheimer's disease in transgenic mice: effect of age and of presenilin1 on amyloid biochemistry and pathology in APP/London mice.

Dewachter I, van Dorpe J, Spittaels K, Tesseur I, Van Den Haute C, Moechars D, Van Leuven F.

Exp Gerontol. 2000 Sep;35(6-7):831-41. Review.

PMID:
11053674
[PubMed - indexed for MEDLINE]
9.

Leucine carboxyl methyltransferase 1 (LCMT1)-dependent methylation regulates the association of protein phosphatase 2A and Tau protein with plasma membrane microdomains in neuroblastoma cells.

Sontag JM, Nunbhakdi-Craig V, Sontag E.

J Biol Chem. 2013 Sep 20;288(38):27396-405. doi: 10.1074/jbc.M113.490102. Epub 2013 Aug 13.

PMID:
23943618
[PubMed - indexed for MEDLINE]
10.

Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice.

Kins S, Crameri A, Evans DR, Hemmings BA, Nitsch RM, Gotz J.

J Biol Chem. 2001 Oct 12;276(41):38193-200. Epub 2001 Jul 25.

PMID:
11473109
[PubMed - indexed for MEDLINE]
Free Article
11.

Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology.

Liu R, Zhou XW, Tanila H, Bjorkdahl C, Wang JZ, Guan ZZ, Cao Y, Gustafsson JA, Winblad B, Pei JJ.

J Cell Mol Med. 2008 Jan-Feb;12(1):241-57. doi: 10.1111/j.1582-4934.2008.00249.x. Epub 2008 Jan 19.

PMID:
18208556
[PubMed - indexed for MEDLINE]
12.

Expression of protein phosphatase 2A mutants and silencing of the regulatory B alpha subunit induce a selective loss of acetylated and detyrosinated microtubules.

Nunbhakdi-Craig V, Schuechner S, Sontag JM, Montgomery L, Pallas DC, Juno C, Mudrak I, Ogris E, Sontag E.

J Neurochem. 2007 May;101(4):959-71. Epub 2007 Mar 23.

PMID:
17394530
[PubMed - indexed for MEDLINE]
13.

Folate is related to phosphorylated neurofilament-H and P-tau (Ser396) in rat brain.

Obeid R, Schlundt J, Umanskaya N, Herrmann W, Herrmann M.

J Neurochem. 2011 Jun;117(6):1047-54. doi: 10.1111/j.1471-4159.2011.07280.x. Epub 2011 May 13.

PMID:
21517845
[PubMed - indexed for MEDLINE]
14.

Asp664 cleavage of amyloid precursor protein induces tau phosphorylation by decreasing protein phosphatase 2A activity.

Park SS, Jung HJ, Kim YJ, Park TK, Kim C, Choi H, Mook-Jung IH, Koo EH, Park SA.

J Neurochem. 2012 Dec;123(5):856-65. doi: 10.1111/jnc.12032. Epub 2012 Oct 25.

PMID:
23020770
[PubMed - indexed for MEDLINE]
15.

PTPA activates protein phosphatase-2A through reducing its phosphorylation at tyrosine-307 with upregulation of protein tyrosine phosphatase 1B.

Luo Y, Nie YJ, Shi HR, Ni ZF, Wang Q, Wang JZ, Liu GP.

Biochim Biophys Acta. 2013 May;1833(5):1235-43. doi: 10.1016/j.bbamcr.2013.02.005. Epub 2013 Feb 19.

PMID:
23428800
[PubMed - indexed for MEDLINE]
Free Article
16.

Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation.

Han P, Dou F, Li F, Zhang X, Zhang YW, Zheng H, Lipton SA, Xu H, Liao FF.

J Neurosci. 2005 Dec 14;25(50):11542-52.

PMID:
16354912
[PubMed - indexed for MEDLINE]
Free Article
17.

Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer's disease mice.

Kocherhans S, Madhusudan A, Doehner J, Breu KS, Nitsch RM, Fritschy JM, Knuesel I.

J Neurosci. 2010 Jul 7;30(27):9228-40. doi: 10.1523/JNEUROSCI.0418-10.2010.

PMID:
20610758
[PubMed - indexed for MEDLINE]
Free Article
18.

Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia.

Planel E, Richter KE, Nolan CE, Finley JE, Liu L, Wen Y, Krishnamurthy P, Herman M, Wang L, Schachter JB, Nelson RB, Lau LF, Duff KE.

J Neurosci. 2007 Mar 21;27(12):3090-7.

PMID:
17376970
[PubMed - indexed for MEDLINE]
Free Article
19.

Loss of Hsp110 leads to age-dependent tau hyperphosphorylation and early accumulation of insoluble amyloid beta.

Eroglu B, Moskophidis D, Mivechi NF.

Mol Cell Biol. 2010 Oct;30(19):4626-43. doi: 10.1128/MCB.01493-09. Epub 2010 Aug 2.

PMID:
20679486
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus.

Zhang CE, Tian Q, Wei W, Peng JH, Liu GP, Zhou XW, Wang Q, Wang DW, Wang JZ.

Neurobiol Aging. 2008 Nov;29(11):1654-65. Epub 2007 May 29.

PMID:
17537547
[PubMed - indexed for MEDLINE]

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