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Results: 1 to 20 of 284

1.

Kinetic and structural characterisation of Escherichia coli nitroreductase mutants showing improved efficacy for the prodrug substrate CB1954.

Race PR, Lovering AL, White SA, Grove JI, Searle PF, Wrighton CW, Hyde EI.

J Mol Biol. 2007 Apr 27;368(2):481-92. Epub 2007 Feb 11.

PMID:
17350040
[PubMed - indexed for MEDLINE]
2.

Steady-state and stopped-flow kinetic studies of three Escherichia coli NfsB mutants with enhanced activity for the prodrug CB1954.

Jarrom D, Jaberipour M, Guise CP, Daff S, White SA, Searle PF, Hyde EI.

Biochemistry. 2009 Aug 18;48(32):7665-72. doi: 10.1021/bi900674m.

PMID:
19580253
[PubMed - indexed for MEDLINE]
3.

Testing double mutants of the enzyme nitroreductase for enhanced cell sensitisation to prodrugs: effects of combining beneficial single mutations.

Jaberipour M, Vass SO, Guise CP, Grove JI, Knox RJ, Hu L, Hyde EI, Searle PF.

Biochem Pharmacol. 2010 Jan 15;79(2):102-11. doi: 10.1016/j.bcp.2009.07.025. Epub 2009 Aug 7.

PMID:
19665450
[PubMed - indexed for MEDLINE]
4.

Mechanism of CB1954 reduction by Escherichia coli nitroreductase.

Christofferson A, Wilkie J.

Biochem Soc Trans. 2009 Apr;37(Pt 2):413-8. doi: 10.1042/BST0370413. Review.

PMID:
19290872
[PubMed - indexed for MEDLINE]
5.

Generation of Escherichia coli nitroreductase mutants conferring improved cell sensitization to the prodrug CB1954.

Grove JI, Lovering AL, Guise C, Race PR, Wrighton CJ, White SA, Hyde EI, Searle PF.

Cancer Res. 2003 Sep 1;63(17):5532-7.

PMID:
14500391
[PubMed - indexed for MEDLINE]
Free Article
6.

Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the inhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form.

Johansson E, Parkinson GN, Denny WA, Neidle S.

J Med Chem. 2003 Sep 11;46(19):4009-20.

PMID:
12954054
[PubMed - indexed for MEDLINE]
7.

The structure of Escherichia coli nitroreductase complexed with nicotinic acid: three crystal forms at 1.7 A, 1.8 A and 2.4 A resolution.

Lovering AL, Hyde EI, Searle PF, White SA.

J Mol Biol. 2001 May 25;309(1):203-13.

PMID:
11491290
[PubMed - indexed for MEDLINE]
8.
9.

Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug CB1954.

Prosser GA, Copp JN, Syddall SP, Williams EM, Smaill JB, Wilson WR, Patterson AV, Ackerley DF.

Biochem Pharmacol. 2010 Mar 1;79(5):678-87. doi: 10.1016/j.bcp.2009.10.008. Epub 2009 Oct 21.

PMID:
19852945
[PubMed - indexed for MEDLINE]
10.

Nitroreductase: a prodrug-activating enzyme for cancer gene therapy.

Searle PF, Chen MJ, Hu L, Race PR, Lovering AL, Grove JI, Guise C, Jaberipour M, James ND, Mautner V, Young LS, Kerr DJ, Mountain A, White SA, Hyde EI.

Clin Exp Pharmacol Physiol. 2004 Nov;31(11):811-6. Review.

PMID:
15566399
[PubMed - indexed for MEDLINE]
11.

Structural and mechanistic studies of Escherichia coli nitroreductase with the antibiotic nitrofurazone. Reversed binding orientations in different redox states of the enzyme.

Race PR, Lovering AL, Green RM, Ossor A, White SA, Searle PF, Wrighton CJ, Hyde EI.

J Biol Chem. 2005 Apr 8;280(14):13256-64. Epub 2005 Jan 31.

PMID:
15684426
[PubMed - indexed for MEDLINE]
Free Article
12.

The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--II. A comparison of an Escherichia coli nitroreductase and Walker DT diaphorase.

Knox RJ, Friedlos F, Sherwood RF, Melton RG, Anlezark GM.

Biochem Pharmacol. 1992 Dec 15;44(12):2297-301.

PMID:
1472095
[PubMed - indexed for MEDLINE]
13.

Direct positive selection for improved nitroreductase variants using SOS triggering of bacteriophage lambda lytic cycle.

Guise CP, Grove JI, Hyde EI, Searle PF.

Gene Ther. 2007 Apr;14(8):690-8. Epub 2007 Feb 15.

PMID:
17301844
[PubMed - indexed for MEDLINE]
14.

E. coli nitroreductase/CB1954 gene-directed enzyme prodrug therapy: role of arylamine N-acetlytransferase 2.

Mitchell DJ, Minchin RF.

Cancer Gene Ther. 2008 Nov;15(11):758-64. doi: 10.1038/cgt.2008.47. Epub 2008 Jul 4.

PMID:
18600257
[PubMed - indexed for MEDLINE]
15.

Bioactivation of dinitrobenzamide mustards by an E. coli B nitroreductase.

Anlezark GM, Melton RG, Sherwood RF, Wilson WR, Denny WA, Palmer BD, Knox RJ, Friedlos F, Williams A.

Biochem Pharmacol. 1995 Aug 25;50(5):609-18.

PMID:
7669063
[PubMed - indexed for MEDLINE]
16.

Nitroreductase from Bacillus licheniformis: a stable enzyme for prodrug activation.

Emptage CD, Knox RJ, Danson MJ, Hough DW.

Biochem Pharmacol. 2009 Jan 1;77(1):21-9. doi: 10.1016/j.bcp.2008.09.010. Epub 2008 Sep 17.

PMID:
18840409
[PubMed - indexed for MEDLINE]
17.

Sensitisation of human carcinoma cells to the prodrug CB1954 by adenovirus vector-mediated expression of E. coli nitroreductase.

Weedon SJ, Green NK, McNeish IA, Gilligan MG, Mautner V, Wrighton CJ, Mountain A, Young LS, Kerr DJ, Searle PF.

Int J Cancer. 2000 Jun 15;86(6):848-54.

PMID:
10842200
[PubMed - indexed for MEDLINE]
18.

Crystal structure of FMN-dependent nitroreductase from Escherichia coli B: a prodrug-activating enzyme.

Parkinson GN, Skelly JV, Neidle S.

J Med Chem. 2000 Oct 5;43(20):3624-31.

PMID:
11020276
[PubMed - indexed for MEDLINE]
19.

Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954.

Bridgewater JA, Springer CJ, Knox RJ, Minton NP, Michael NP, Collins MK.

Eur J Cancer. 1995 Dec;31A(13-14):2362-70. Erratum in: Eur J Cancer 1996 Jan;32A(1):186.

PMID:
8652270
[PubMed - indexed for MEDLINE]
20.

Aziridinyldinitrobenzamides: synthesis and structure-activity relationships for activation by E. coli nitroreductase.

Helsby NA, Atwell GJ, Yang S, Palmer BD, Anderson RF, Pullen SM, Ferry DM, Hogg A, Wilson WR, Denny WA.

J Med Chem. 2004 Jun 3;47(12):3295-307.

PMID:
15163209
[PubMed - indexed for MEDLINE]
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