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Dietary synbiotics reduce cancer risk factors in polypectomized and colon cancer patients.

Rafter J, Bennett M, Caderni G, Clune Y, Hughes R, Karlsson PC, Klinder A, O'Riordan M, O'Sullivan GC, Pool-Zobel B, Rechkemmer G, Roller M, Rowland I, Salvadori M, Thijs H, Van Loo J, Watzl B, Collins JK.

Am J Clin Nutr. 2007 Feb;85(2):488-96.


Antitumorigenic activity of the prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis on azoxymethane-induced colon carcinogenesis in rats.

Femia AP, Luceri C, Dolara P, Giannini A, Biggeri A, Salvadori M, Clune Y, Collins KJ, Paglierani M, Caderni G.

Carcinogenesis. 2002 Nov;23(11):1953-60.


A human, double-blind, placebo-controlled, crossover trial of prebiotic, probiotic, and synbiotic supplementation: effects on luminal, inflammatory, epigenetic, and epithelial biomarkers of colorectal cancer.

Worthley DL, Le Leu RK, Whitehall VL, Conlon M, Christophersen C, Belobrajdic D, Mallitt KA, Hu Y, Irahara N, Ogino S, Leggett BA, Young GP.

Am J Clin Nutr. 2009 Sep;90(3):578-86. doi: 10.3945/ajcn.2009.28106. Epub 2009 Jul 29.


The SYNCAN project: goals, set-up, first results and settings of the human intervention study.

Van Loo J, Clune Y, Bennett M, Collins JK.

Br J Nutr. 2005 Apr;93 Suppl 1:S91-8.


A synbiotic combination of resistant starch and Bifidobacterium lactis facilitates apoptotic deletion of carcinogen-damaged cells in rat colon.

Le Leu RK, Brown IL, Hu Y, Bird AR, Jackson M, Esterman A, Young GP.

J Nutr. 2005 May;135(5):996-1001.


Effects of Lactobacillus casei Shirota, Bifidobacterium breve, and oligofructose-enriched inulin on colonic nitrogen-protein metabolism in healthy humans.

De Preter V, Vanhoutte T, Huys G, Swings J, De Vuyst L, Rutgeerts P, Verbeke K.

Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G358-68. Epub 2006 Sep 21.


Food-based strategies to modulate the composition of the intestinal microbiota and their associated health effects.

Bosscher D, Breynaert A, Pieters L, Hermans N.

J Physiol Pharmacol. 2009 Dec;60 Suppl 6:5-11. Review.


Randomized, double-blinded, placebo-controlled intervention study with supplemental calcium in families with hereditary nonpolyposis colorectal cancer.

Cats A, Kleibeuker JH, van der Meer R, Kuipers F, Sluiter WJ, Hardonk MJ, Oremus ET, Mulder NH, de Vries EG.

J Natl Cancer Inst. 1995 Apr 19;87(8):598-603.


Long-term safety and impact on infection rates of postnatal probiotic and prebiotic (synbiotic) treatment: randomized, double-blind, placebo-controlled trial.

Kukkonen K, Savilahti E, Haahtela T, Juntunen-Backman K, Korpela R, Poussa T, Tuure T, Kuitunen M.

Pediatrics. 2008 Jul;122(1):8-12. doi: 10.1542/peds.2007-1192.


A randomized controlled trial on the efficacy of synbiotic versus probiotic or prebiotic treatment to improve the quality of life in patients with ulcerative colitis.

Fujimori S, Gudis K, Mitsui K, Seo T, Yonezawa M, Tanaka S, Tatsuguchi A, Sakamoto C.

Nutrition. 2009 May;25(5):520-5. doi: 10.1016/j.nut.2008.11.017. Epub 2009 Feb 8.


A new chance of preventing winter diseases by the administration of synbiotic formulations.

Pregliasco F, Anselmi G, Fonte L, Giussani F, Schieppati S, Soletti L.

J Clin Gastroenterol. 2008 Sep;42 Suppl 3 Pt 2:S224-33. doi: 10.1097/MCG.0b013e31817e1c91.


Effects of synbiotic food consumption on metabolic status of diabetic patients: a double-blind randomized cross-over controlled clinical trial.

Asemi Z, Khorrami-Rad A, Alizadeh SA, Shakeri H, Esmaillzadeh A.

Clin Nutr. 2014 Apr;33(2):198-203. doi: 10.1016/j.clnu.2013.05.015. Epub 2013 Jun 7.


Effects of a synbiotic milk product on human intestinal ecosystem.

Casiraghi MC, Canzi E, Zanchi R, Donati E, Villa L.

J Appl Microbiol. 2007 Aug;103(2):499-506.

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