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Items: 1 to 20 of 210

1.

Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes.

Roose JP, Mollenauer M, Ho M, Kurosaki T, Weiss A.

Mol Cell Biol. 2007 Apr;27(7):2732-45. Epub 2007 Feb 5.

2.

Activation of extracellular signal-regulated kinase but not of p38 mitogen-activated protein kinase pathways in lymphocytes requires allosteric activation of SOS.

Jun JE, Yang M, Chen H, Chakraborty AK, Roose JP.

Mol Cell Biol. 2013 Jun;33(12):2470-84. doi: 10.1128/MCB.01593-12. Epub 2013 Apr 15.

3.

Vav1 transduces T cell receptor signals to the activation of the Ras/ERK pathway via LAT, Sos, and RasGRP1.

Reynolds LF, de Bettignies C, Norton T, Beeser A, Chernoff J, Tybulewicz VL.

J Biol Chem. 2004 Apr 30;279(18):18239-46. Epub 2004 Feb 5.

4.

Sos1 regulates sustained TCR-mediated Erk activation.

Poltorak M, Meinert I, Stone JC, Schraven B, Simeoni L.

Eur J Immunol. 2014 May;44(5):1535-40. doi: 10.1002/eji.201344046. Epub 2014 Feb 20.

5.

Ras activation in response to phorbol ester proceeds independently of the EGFR via an unconventional nucleotide-exchange factor system in COS-7 cells.

Rubio I, Rennert K, Wittig U, Beer K, Dürst M, Stang SL, Stone J, Wetzker R.

Biochem J. 2006 Sep 1;398(2):243-56.

6.

Digital signaling and hysteresis characterize ras activation in lymphoid cells.

Das J, Ho M, Zikherman J, Govern C, Yang M, Weiss A, Chakraborty AK, Roose JP.

Cell. 2009 Jan 23;136(2):337-51. doi: 10.1016/j.cell.2008.11.051.

7.

Preferential development of CD4 and CD8 T regulatory cells in RasGRP1-deficient mice.

Chen X, Priatel JJ, Chow MT, Teh HS.

J Immunol. 2008 May 1;180(9):5973-82.

8.

Differences in flexibility underlie functional differences in the Ras activators son of sevenless and Ras guanine nucleotide releasing factor 1.

Freedman TS, Sondermann H, Kuchment O, Friedland GD, Kortemme T, Kuriyan J.

Structure. 2009 Jan 14;17(1):41-53. doi: 10.1016/j.str.2008.11.004.

9.

T cell activation in vivo targets diacylglycerol kinase alpha to the membrane: a novel mechanism for Ras attenuation.

Sanjuán MA, Pradet-Balade B, Jones DR, Martínez-A C, Stone JC, Garcia-Sanz JA, Mérida I.

J Immunol. 2003 Mar 15;170(6):2877-83.

10.

RasGRP links T-cell receptor signaling to Ras.

Ebinu JO, Stang SL, Teixeira C, Bottorff DA, Hooton J, Blumberg PM, Barry M, Bleakley RC, Ostergaard HL, Stone JC.

Blood. 2000 May 15;95(10):3199-203.

11.

A Ras-induced conformational switch in the Ras activator Son of sevenless.

Freedman TS, Sondermann H, Friedland GD, Kortemme T, Bar-Sagi D, Marqusee S, Kuriyan J.

Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16692-7. Epub 2006 Oct 30.

12.

A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells.

Roose JP, Mollenauer M, Gupta VA, Stone J, Weiss A.

Mol Cell Biol. 2005 Jun;25(11):4426-41.

13.

Structural analysis of autoinhibition in the Ras activator Son of sevenless.

Sondermann H, Soisson SM, Boykevisch S, Yang SS, Bar-Sagi D, Kuriyan J.

Cell. 2004 Oct 29;119(3):393-405.

14.

Prenylation of Ras facilitates hSOS1-promoted nucleotide exchange, upon Ras binding to the regulatory site.

Pechlivanis M, Ringel R, Popkirova B, Kuhlmann J.

Biochemistry. 2007 May 8;46(18):5341-8. Epub 2007 Apr 17.

PMID:
17437339
15.

Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS.

Margarit SM, Sondermann H, Hall BE, Nagar B, Hoelz A, Pirruccello M, Bar-Sagi D, Kuriyan J.

Cell. 2003 Mar 7;112(5):685-95.

16.

Mechanisms through which Sos-1 coordinates the activation of Ras and Rac.

Innocenti M, Tenca P, Frittoli E, Faretta M, Tocchetti A, Di Fiore PP, Scita G.

J Cell Biol. 2002 Jan 7;156(1):125-36. Epub 2002 Jan 3.

17.

RasGRP1 and RasGRP3 regulate B cell proliferation by facilitating B cell receptor-Ras signaling.

Coughlin JJ, Stang SL, Dower NA, Stone JC.

J Immunol. 2005 Dec 1;175(11):7179-84.

18.

Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells.

Zheng Y, Liu H, Coughlin J, Zheng J, Li L, Stone JC.

Blood. 2005 May 1;105(9):3648-54. Epub 2005 Jan 18.

19.

Regulation of ras signaling dynamics by Sos-mediated positive feedback.

Boykevisch S, Zhao C, Sondermann H, Philippidou P, Halegoua S, Kuriyan J, Bar-Sagi D.

Curr Biol. 2006 Nov 7;16(21):2173-9.

20.

Signal transduction in T lymphocytes using a conditional allele of Sos.

Holsinger LJ, Spencer DM, Austin DJ, Schreiber SL, Crabtree GR.

Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9810-4.

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