Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Results: 1 to 20 of 57

1.

Properties of scyllo-inositol as a therapeutic treatment of AD-like pathology.

Fenili D, Brown M, Rappaport R, McLaurin J.

J Mol Med (Berl). 2007 Jun;85(6):603-11. Epub 2007 Feb 6.

PMID:
17279347
[PubMed - indexed for MEDLINE]
2.

Small molecule beta-amyloid inhibitors that stabilize protofibrillar structures in vitro improve cognition and pathology in a mouse model of Alzheimer's disease.

Hawkes CA, Deng LH, Shaw JE, Nitz M, McLaurin J.

Eur J Neurosci. 2010 Jan;31(2):203-13. doi: 10.1111/j.1460-9568.2009.07052.x. Epub 2010 Jan 13.

PMID:
20074226
[PubMed - indexed for MEDLINE]
3.

Combination therapy in a transgenic model of Alzheimer's disease.

Aytan N, Choi JK, Carreras I, Kowall NW, Jenkins BG, Dedeoglu A.

Exp Neurol. 2013 Dec;250:228-38. doi: 10.1016/j.expneurol.2013.10.001. Epub 2013 Oct 10.

PMID:
24120437
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Sodium/myo-Inositol transporters: substrate transport requirements and regional brain expression in the TgCRND8 mouse model of amyloid pathology.

Fenili D, Weng YQ, Aubert I, Nitz M, McLaurin J.

PLoS One. 2011;6(8):e24032. doi: 10.1371/journal.pone.0024032. Epub 2011 Aug 26.

PMID:
21887366
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Inhibition of amyloid-beta peptide aggregation rescues the autophagic deficits in the TgCRND8 mouse model of Alzheimer disease.

Lai AY, McLaurin J.

Biochim Biophys Acta. 2012 Oct;1822(10):1629-37. doi: 10.1016/j.bbadis.2012.07.003. Epub 2012 Jul 16.

PMID:
22800931
[PubMed - indexed for MEDLINE]
Free Article
6.

scyllo-Inositol, preclinical, and clinical data for Alzheimer's disease.

Ma K, Thomason LA, McLaurin J.

Adv Pharmacol. 2012;64:177-212. doi: 10.1016/B978-0-12-394816-8.00006-4. Review.

PMID:
22840748
[PubMed - indexed for MEDLINE]
7.

A cell factory of Bacillus subtilis engineered for the simple bioconversion of myo-inositol to scyllo-inositol, a potential therapeutic agent for Alzheimer's disease.

Yamaoka M, Osawa S, Morinaga T, Takenaka S, Yoshida K.

Microb Cell Fact. 2011 Sep 7;10:69. doi: 10.1186/1475-2859-10-69.

PMID:
21896210
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

1-Deoxy-1-[18F]fluoro-scyllo-inositol.

Leung K.

Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013.
2011 Dec 07 [updated 2012 Mar 22].

9.

Inositol stereoisomers stabilize an oligomeric aggregate of Alzheimer amyloid beta peptide and inhibit abeta -induced toxicity.

McLaurin J, Golomb R, Jurewicz A, Antel JP, Fraser PE.

J Biol Chem. 2000 Jun 16;275(24):18495-502.

PMID:
10764800
[PubMed - indexed for MEDLINE]
Free Article
10.

Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers.

Townsend M, Cleary JP, Mehta T, Hofmeister J, Lesne S, O'Hare E, Walsh DM, Selkoe DJ.

Ann Neurol. 2006 Dec;60(6):668-76.

PMID:
17192927
[PubMed - indexed for MEDLINE]
11.

Synthesis of scyllo-inositol derivatives and their effects on amyloid beta peptide aggregation.

Sun Y, Zhang G, Hawkes CA, Shaw JE, McLaurin J, Nitz M.

Bioorg Med Chem. 2008 Aug 1;16(15):7177-84. doi: 10.1016/j.bmc.2008.06.045. Epub 2008 Jun 26.

PMID:
18635362
[PubMed - indexed for MEDLINE]
12.

Phosphatidylinositol and inositol involvement in Alzheimer amyloid-beta fibril growth and arrest.

McLaurin J, Franklin T, Chakrabartty A, Fraser PE.

J Mol Biol. 1998 Apr 24;278(1):183-94.

PMID:
9571042
[PubMed - indexed for MEDLINE]
13.

Binding mechanism of inositol stereoisomers to monomers and aggregates of Aβ(16-22).

Li G, Pomès R.

J Phys Chem B. 2013 Jun 6;117(22):6603-13. doi: 10.1021/jp311350r. Epub 2013 May 23.

PMID:
23627280
[PubMed - indexed for MEDLINE]
14.

Detection of increased scyllo-inositol in brain with magnetic resonance spectroscopy after dietary supplementation in Alzheimer's disease mouse models.

Choi JK, Carreras I, Dedeoglu A, Jenkins BG.

Neuropharmacology. 2010 Sep-Oct;59(4-5):353-7. doi: 10.1016/j.neuropharm.2010.03.011. Epub 2010 Apr 22.

PMID:
20399219
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

APP transgenic mouse models and their use in drug discovery to evaluate amyloid- lowering therapeutics.

Hussain I.

CNS Neurol Disord Drug Targets. 2010 Aug;9(4):395-402. Review.

PMID:
20522015
[PubMed - indexed for MEDLINE]
16.

The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease.

Hutter-Paier B, Huttunen HJ, Puglielli L, Eckman CB, Kim DY, Hofmeister A, Moir RD, Domnitz SB, Frosch MP, Windisch M, Kovacs DM.

Neuron. 2004 Oct 14;44(2):227-38. Erratum in: Neuron. 2010 Dec 9;68(5):1014.

PMID:
15473963
[PubMed - indexed for MEDLINE]
17.

Phosphoinositide metabolism in the developing conceptus. Effects of hyperglycemia and scyllo-inositol in rat embryo culture.

Strieleman PJ, Connors MA, Metzger BE.

Diabetes. 1992 Aug;41(8):989-97.

PMID:
1321063
[PubMed - indexed for MEDLINE]
18.

Simple in vitro assays to identify amyloid-beta aggregation blockers for Alzheimer's disease therapy.

Guo JP, Yu S, McGeer PL.

J Alzheimers Dis. 2010;19(4):1359-70. doi: 10.3233/JAD-2010-1331.

PMID:
20061605
[PubMed - indexed for MEDLINE]
19.

Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits.

Kowa H, Sakakura T, Matsuura Y, Wakabayashi T, Mann DM, Duff K, Tsuji S, Hashimoto T, Iwatsubo T.

Am J Pathol. 2004 Jul;165(1):273-81.

PMID:
15215182
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Modeling Alzheimer's disease in transgenic mice: effect of age and of presenilin1 on amyloid biochemistry and pathology in APP/London mice.

Dewachter I, van Dorpe J, Spittaels K, Tesseur I, Van Den Haute C, Moechars D, Van Leuven F.

Exp Gerontol. 2000 Sep;35(6-7):831-41. Review.

PMID:
11053674
[PubMed - indexed for MEDLINE]

Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk