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Potent cell growth inhibitory effects in hepatitis B virus X protein positive hepatocellular carcinoma cells by the selective cyclooxygenase-2 inhibitor celecoxib.

Xie H, Gao L, Chai N, Song J, Wang J, Song Z, Chen C, Pan Y, Zhao L, Sun S, Wu K, Feitelson MA, Liu J, Fan D.

Mol Carcinog. 2009 Jan;48(1):56-65. doi: 10.1002/mc.20455.


Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells.

Li F, Fernandez PP, Rajendran P, Hui KM, Sethi G.

Cancer Lett. 2010 Jun 28;292(2):197-207. doi: 10.1016/j.canlet.2009.12.003. Epub 2010 Jan 6.


PI3K-AKT pathway negatively controls EGFR-dependent DNA-binding activity of Stat3 in glioblastoma multiforme cells.

Ghosh MK, Sharma P, Harbor PC, Rahaman SO, Haque SJ.

Oncogene. 2005 Nov 10;24(49):7290-300.


Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1.

Rajendran P, Li F, Shanmugam MK, Vali S, Abbasi T, Kapoor S, Ahn KS, Kumar AP, Sethi G.

J Cell Physiol. 2012 May;227(5):2184-95. doi: 10.1002/jcp.22954.


Pleiotropic effects of PI-3' kinase/Akt signaling in human hepatoma cell proliferation and drug-induced apoptosis.

Alexia C, Bras M, Fallot G, Vadrot N, Daniel F, Lasfer M, Tamouza H, Groyer A.

Ann N Y Acad Sci. 2006 Dec;1090:1-17.


Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation.

Bhutani M, Pathak AK, Nair AS, Kunnumakkara AB, Guha S, Sethi G, Aggarwal BB.

Clin Cancer Res. 2007 May 15;13(10):3024-32.


c-Jun NH(2)-terminal kinase mediates leptin-stimulated androgen-independent prostate cancer cell proliferation via signal transducer and activator of transcription 3 and Akt.

Miyazaki T, Bub JD, Iwamoto Y.

Biochim Biophys Acta. 2008 Oct;1782(10):593-604. doi: 10.1016/j.bbadis.2008.07.005. Epub 2008 Aug 5.


Role of Rel/NF-kappaB transcription factors in apoptosis of human hepatocellular carcinoma cells.

Chiao PJ, Na R, Niu J, Sclabas GM, Dong Q, Curley SA.

Cancer. 2002 Oct 15;95(8):1696-705.


Regulation of hepatitis B virus replication by the phosphatidylinositol 3-kinase-akt signal transduction pathway.

Guo H, Zhou T, Jiang D, Cuconati A, Xiao GH, Block TM, Guo JT.

J Virol. 2007 Sep;81(18):10072-80. Epub 2007 Jul 3.


Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3.

Subramaniam A, Shanmugam MK, Ong TH, Li F, Perumal E, Chen L, Vali S, Abbasi T, Kapoor S, Ahn KS, Kumar AP, Hui KM, Sethi G.

Br J Pharmacol. 2013 Oct;170(4):807-21. doi: 10.1111/bph.12302.


Cyclooxygenase-2-dependent activation of signal transducer and activator of transcription 3 by interleukin-6 in non-small cell lung cancer.

Dalwadi H, Krysan K, Heuze-Vourc'h N, Dohadwala M, Elashoff D, Sharma S, Cacalano N, Lichtenstein A, Dubinett S.

Clin Cancer Res. 2005 Nov 1;11(21):7674-82.


Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells.

Tabe Y, Jin L, Tsutsumi-Ishii Y, Xu Y, McQueen T, Priebe W, Mills GB, Ohsaka A, Nagaoka I, Andreeff M, Konopleva M.

Cancer Res. 2007 Jan 15;67(2):684-94.


Interferon-gamma-induced dephosphorylation of STAT3 and apoptosis are dependent on the mTOR pathway.

Fang P, Hwa V, Rosenfeld RG.

Exp Cell Res. 2006 May 1;312(8):1229-39. Epub 2006 Jan 19.


OSU-03012, a novel celecoxib derivative, is cytotoxic to myeloma cells and acts through multiple mechanisms.

Zhang S, Suvannasankha A, Crean CD, White VL, Johnson A, Chen CS, Farag SS.

Clin Cancer Res. 2007 Aug 15;13(16):4750-8.


Indomethacin induces apoptosis in 786-O renal cell carcinoma cells by activating mitogen-activated protein kinases and AKT.

Ou YC, Yang CR, Cheng CL, Raung SL, Hung YY, Chen CJ.

Eur J Pharmacol. 2007 Jun 1;563(1-3):49-60. Epub 2007 Feb 8.


γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent.

Rajendran P, Li F, Manu KA, Shanmugam MK, Loo SY, Kumar AP, Sethi G.

Br J Pharmacol. 2011 May;163(2):283-98. doi: 10.1111/j.1476-5381.2010.01187.x.


Downregulation of survivin and activation of caspase-3 through the PI3K/Akt pathway in ursolic acid-induced HepG2 cell apoptosis.

Tang C, Lu YH, Xie JH, Wang F, Zou JN, Yang JS, Xing YY, Xi T.

Anticancer Drugs. 2009 Apr;20(4):249-58. doi: 10.1097/CAD.0b013e328327d476.


Down-regulation of phospho-Akt is a major molecular determinant of bortezomib-induced apoptosis in hepatocellular carcinoma cells.

Chen KF, Yeh PY, Yeh KH, Lu YS, Huang SY, Cheng AL.

Cancer Res. 2008 Aug 15;68(16):6698-707. doi: 10.1158/0008-5472.CAN-08-0257.

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