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Mechanisms underlying the resistance to diet-induced obesity in germ-free mice.

Bäckhed F, Manchester JK, Semenkovich CF, Gordon JI.

Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):979-84. Epub 2007 Jan 8.


Effects of alpha-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle.

Jørgensen SB, Wojtaszewski JF, Viollet B, Andreelli F, Birk JB, Hellsten Y, Schjerling P, Vaulont S, Neufer PD, Richter EA, Pilegaard H.

FASEB J. 2005 Jul;19(9):1146-8. Epub 2005 May 5.


The gut microbiota as an environmental factor that regulates fat storage.

Bäckhed F, Ding H, Wang T, Hooper LV, Koh GY, Nagy A, Semenkovich CF, Gordon JI.

Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15718-23. Epub 2004 Oct 25.


Energy-sensing factors coactivator peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) and AMP-activated protein kinase control expression of inflammatory mediators in liver: induction of interleukin 1 receptor antagonist.

Buler M, Aatsinki SM, Skoumal R, Komka Z, Tóth M, Kerkelä R, Georgiadi A, Kersten S, Hakkola J.

J Biol Chem. 2012 Jan 13;287(3):1847-60. doi: 10.1074/jbc.M111.302356. Epub 2011 Nov 23.


Skeletal muscle AMP-activated protein kinase phosphorylation parallels metabolic phenotype in leptin transgenic mice under dietary modification.

Tanaka T, Hidaka S, Masuzaki H, Yasue S, Minokoshi Y, Ebihara K, Chusho H, Ogawa Y, Toyoda T, Sato K, Miyanaga F, Fujimoto M, Tomita T, Kusakabe T, Kobayashi N, Tanioka H, Hayashi T, Hosoda K, Yoshimatsu H, Sakata T, Nakao K.

Diabetes. 2005 Aug;54(8):2365-74.


Absence of intestinal microbiota does not protect mice from diet-induced obesity.

Fleissner CK, Huebel N, Abd El-Bary MM, Loh G, Klaus S, Blaut M.

Br J Nutr. 2010 Sep;104(6):919-29. doi: 10.1017/S0007114510001303. Epub 2010 May 5.


Role of AMP-activated protein kinase in the coordinated expression of genes controlling glucose and lipid metabolism in mouse white skeletal muscle.

Long YC, Barnes BR, Mahlapuu M, Steiler TL, Martinsson S, Leng Y, Wallberg-Henriksson H, Andersson L, Zierath JR.

Diabetologia. 2005 Nov;48(11):2354-64. Epub 2005 Oct 20.


The PPARβ/δ activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-Lipin 1-PPARα pathway leading to increased fatty acid oxidation.

Barroso E, Rodríguez-Calvo R, Serrano-Marco L, Astudillo AM, Balsinde J, Palomer X, Vázquez-Carrera M.

Endocrinology. 2011 May;152(5):1848-59. doi: 10.1210/en.2010-1468. Epub 2011 Mar 1.


Interactions between the consumption of a high-fat diet and fasting in the regulation of fatty acid oxidation enzyme gene expression: an evaluation of potential mechanisms.

Frier BC, Jacobs RL, Wright DC.

Am J Physiol Regul Integr Comp Physiol. 2011 Feb;300(2):R212-21. doi: 10.1152/ajpregu.00367.2010. Epub 2010 Nov 17.


AMP-activated protein kinase phosphorylates transcription factors of the CREB family.

Thomson DM, Herway ST, Fillmore N, Kim H, Brown JD, Barrow JR, Winder WW.

J Appl Physiol (1985). 2008 Feb;104(2):429-38. Epub 2007 Dec 6.


Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver.

Dobrzyn P, Dobrzyn A, Miyazaki M, Cohen P, Asilmaz E, Hardie DG, Friedman JM, Ntambi JM.

Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6409-14. Epub 2004 Apr 19.


Stearoyl-CoA desaturase--a new player in skeletal muscle metabolism regulation.

Dobrzyń A, Dobrzyń P.

J Physiol Pharmacol. 2006 Nov;57 Suppl 10:31-42. Review.


Parenteral 17beta-estradiol decreases fasting blood glucose levels in non-obese mice with short-term ovariectomy.

Kim JY, Jo KJ, Kim OS, Kim BJ, Kang DW, Lee KH, Baik HW, Han MS, Lee SK.

Life Sci. 2010 Sep 11;87(11-12):358-66. doi: 10.1016/j.lfs.2010.07.009. Epub 2010 Jul 23.


Effects and action mechanisms of berberine and Rhizoma coptidis on gut microbes and obesity in high-fat diet-fed C57BL/6J mice.

Xie W, Gu D, Li J, Cui K, Zhang Y.

PLoS One. 2011;6(9):e24520. doi: 10.1371/journal.pone.0024520. Epub 2011 Sep 6.


Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle.

Dobrzyn A, Dobrzyn P, Lee SH, Miyazaki M, Cohen P, Asilmaz E, Hardie DG, Friedman JM, Ntambi JM.

Am J Physiol Endocrinol Metab. 2005 Mar;288(3):E599-607. Epub 2004 Nov 23.


Dietary phytoestrogens activate AMP-activated protein kinase with improvement in lipid and glucose metabolism.

Cederroth CR, Vinciguerra M, Gjinovci A, Kühne F, Klein M, Cederroth M, Caille D, Suter M, Neumann D, James RW, Doerge DR, Wallimann T, Meda P, Foti M, Rohner-Jeanrenaud F, Vassalli JD, Nef S.

Diabetes. 2008 May;57(5):1176-85. doi: 10.2337/db07-0630. Epub 2008 Apr 16.


The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity.

Mandard S, Zandbergen F, van Straten E, Wahli W, Kuipers F, Müller M, Kersten S.

J Biol Chem. 2006 Jan 13;281(2):934-44. Epub 2005 Nov 4. Erratum in: J Biol Chem. 2006 Jul 28;281(30):21575.


Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice.

Li H, Xu M, Lee J, He C, Xie Z.

Am J Physiol Endocrinol Metab. 2012 Nov 15;303(10):E1234-44. doi: 10.1152/ajpendo.00198.2012. Epub 2012 Sep 11.


Induced adiposity and adipocyte hypertrophy in mice lacking the AMP-activated protein kinase-alpha2 subunit.

Villena JA, Viollet B, Andreelli F, Kahn A, Vaulont S, Sul HS.

Diabetes. 2004 Sep;53(9):2242-9.

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