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Results: 1 to 20 of 234

1.

Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation.

Lamothe B, Besse A, Campos AD, Webster WK, Wu H, Darnay BG.

J Biol Chem. 2007 Feb 9;282(6):4102-12. Epub 2006 Nov 29.

PMID:
17135271
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

The RING domain and first zinc finger of TRAF6 coordinate signaling by interleukin-1, lipopolysaccharide, and RANKL.

Lamothe B, Campos AD, Webster WK, Gopinathan A, Hur L, Darnay BG.

J Biol Chem. 2008 Sep 5;283(36):24871-80. doi: 10.1074/jbc.M802749200. Epub 2008 Jul 10.

PMID:
18617513
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

The coiled-coil domain of TRAF6 is essential for its auto-ubiquitination.

Yang K, Zhu J, Sun S, Tang Y, Zhang B, Diao L, Wang C.

Biochem Biophys Res Commun. 2004 Nov 5;324(1):432-9.

PMID:
15465037
[PubMed - indexed for MEDLINE]
4.

Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation.

Fan Y, Yu Y, Shi Y, Sun W, Xie M, Ge N, Mao R, Chang A, Xu G, Schneider MD, Zhang H, Fu S, Qin J, Yang J.

J Biol Chem. 2010 Feb 19;285(8):5347-60. doi: 10.1074/jbc.M109.076976. Epub 2009 Dec 28.

PMID:
20038579
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

TRAF6 ubiquitin ligase is essential for RANKL signaling and osteoclast differentiation.

Lamothe B, Webster WK, Gopinathan A, Besse A, Campos AD, Darnay BG.

Biochem Biophys Res Commun. 2007 Aug 10;359(4):1044-9. Epub 2007 Jun 11.

PMID:
17572386
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes.

Sun L, Deng L, Ea CK, Xia ZP, Chen ZJ.

Mol Cell. 2004 May 7;14(3):289-301.

PMID:
15125833
[PubMed - indexed for MEDLINE]
Free Article
7.

TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6.

Ea CK, Sun L, Inoue J, Chen ZJ.

Proc Natl Acad Sci U S A. 2004 Oct 26;101(43):15318-23. Epub 2004 Oct 18.

PMID:
15492226
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

NOD2 pathway activation by MDP or Mycobacterium tuberculosis infection involves the stable polyubiquitination of Rip2.

Yang Y, Yin C, Pandey A, Abbott D, Sassetti C, Kelliher MA.

J Biol Chem. 2007 Dec 14;282(50):36223-9. Epub 2007 Oct 18.

PMID:
17947236
[PubMed - indexed for MEDLINE]
Free Article
9.

Direct activation of protein kinases by unanchored polyubiquitin chains.

Xia ZP, Sun L, Chen X, Pineda G, Jiang X, Adhikari A, Zeng W, Chen ZJ.

Nature. 2009 Sep 3;461(7260):114-9. doi: 10.1038/nature08247. Epub 2009 Aug 12.

PMID:
19675569
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation.

Hinz M, Stilmann M, Arslan SÇ, Khanna KK, Dittmar G, Scheidereit C.

Mol Cell. 2010 Oct 8;40(1):63-74. doi: 10.1016/j.molcel.2010.09.008.

PMID:
20932475
[PubMed - indexed for MEDLINE]
Free Article
11.

TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL.

Walsh MC, Kim GK, Maurizio PL, Molnar EE, Choi Y.

PLoS One. 2008;3(12):e4064. doi: 10.1371/journal.pone.0004064. Epub 2008 Dec 29.

PMID:
19112497
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

TRAF6 negatively regulates TNFalpha-induced NF-kappaB activation.

Funakoshi-Tago M, Kamada N, Shimizu T, Hashiguchi Y, Tago K, Sonoda Y, Kasahara T.

Cytokine. 2009 Feb;45(2):72-9. doi: 10.1016/j.cyto.2008.10.010. Epub 2008 Dec 16.

PMID:
19091594
[PubMed - indexed for MEDLINE]
13.

Two mechanistically and temporally distinct NF-kappaB activation pathways in IL-1 signaling.

Yamazaki K, Gohda J, Kanayama A, Miyamoto Y, Sakurai H, Yamamoto M, Akira S, Hayashi H, Su B, Inoue J.

Sci Signal. 2009 Oct 20;2(93):ra66. doi: 10.1126/scisignal.2000387.

PMID:
19843958
[PubMed - indexed for MEDLINE]
Free Article
14.

TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway.

Kishida S, Sanjo H, Akira S, Matsumoto K, Ninomiya-Tsuji J.

Genes Cells. 2005 May;10(5):447-54.

PMID:
15836773
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2.

Alvarez SE, Harikumar KB, Hait NC, Allegood J, Strub GM, Kim EY, Maceyka M, Jiang H, Luo C, Kordula T, Milstien S, Spiegel S.

Nature. 2010 Jun 24;465(7301):1084-8. doi: 10.1038/nature09128.

PMID:
20577214
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

TAK1 lysine 158 is required for TGF-β-induced TRAF6-mediated Smad-independent IKK/NF-κB and JNK/AP-1 activation.

Mao R, Fan Y, Mou Y, Zhang H, Fu S, Yang J.

Cell Signal. 2011 Jan;23(1):222-7. doi: 10.1016/j.cellsig.2010.09.006. Epub 2010 Sep 16.

PMID:
20837137
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Polyubiquitination events mediate polymethylmethacrylate (PMMA) particle activation of NF-kappaB pathway.

Yamanaka Y, Karuppaiah K, Abu-Amer Y.

J Biol Chem. 2011 Jul 8;286(27):23735-41. doi: 10.1074/jbc.M111.223669. Epub 2011 May 12.

PMID:
21566132
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

TRAF6 and the three C-terminal lysine sites on IRF7 are required for its ubiquitination-mediated activation by the tumor necrosis factor receptor family member latent membrane protein 1.

Ning S, Campos AD, Darnay BG, Bentz GL, Pagano JS.

Mol Cell Biol. 2008 Oct;28(20):6536-46. doi: 10.1128/MCB.00785-08. Epub 2008 Aug 18.

PMID:
18710948
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Mutational analysis of TRAF6 reveals a conserved functional role of the RING dimerization interface and a potentially necessary but insufficient role of RING-dependent TRAF6 polyubiquitination towards NF-κB activation.

Megas C, Hatzivassiliou EG, Yin Q, Marinopoulou E, Hadweh P, Vignali DA, Mosialos G.

Cell Signal. 2011 May;23(5):772-7. doi: 10.1016/j.cellsig.2010.12.004. Epub 2010 Dec 23.

PMID:
21185369
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected].

Wu CJ, Conze DB, Li T, Srinivasula SM, Ashwell JD.

Nat Cell Biol. 2006 Apr;8(4):398-406. Epub 2006 Mar 19. Erratum in: Nat Cell Biol. 2006 Apr;8(4):424.

PMID:
16547522
[PubMed - indexed for MEDLINE]

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