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Results: 1 to 20 of 320

1.

The cytoplasmic Hsp70 chaperone machinery subjects misfolded and endoplasmic reticulum import-incompetent proteins to degradation via the ubiquitin-proteasome system.

Park SH, Bolender N, Eisele F, Kostova Z, Takeuchi J, Coffino P, Wolf DH.

Mol Biol Cell. 2007 Jan;18(1):153-65. Epub 2006 Oct 25.

PMID:
17065559
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein.

Huyer G, Piluek WF, Fansler Z, Kreft SG, Hochstrasser M, Brodsky JL, Michaelis S.

J Biol Chem. 2004 Sep 10;279(37):38369-78. Epub 2004 Jul 12.

PMID:
15252059
[PubMed - indexed for MEDLINE]
Free Article
3.

Hsp70 targets a cytoplasmic quality control substrate to the San1p ubiquitin ligase.

Guerriero CJ, Weiberth KF, Brodsky JL.

J Biol Chem. 2013 Jun 21;288(25):18506-20. doi: 10.1074/jbc.M113.475905. Epub 2013 May 7.

PMID:
23653356
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Cytoplasmic Hsp70 promotes ubiquitination for endoplasmic reticulum-associated degradation of a misfolded mutant of the yeast plasma membrane ATPase, PMA1.

Han S, Liu Y, Chang A.

J Biol Chem. 2007 Sep 7;282(36):26140-9. Epub 2007 Jul 13.

PMID:
17631501
[PubMed - indexed for MEDLINE]
Free Article
5.

Degradation of a cytosolic protein requires endoplasmic reticulum-associated degradation machinery.

Metzger MB, Maurer MJ, Dancy BM, Michaelis S.

J Biol Chem. 2008 Nov 21;283(47):32302-16. doi: 10.1074/jbc.M806424200. Epub 2008 Sep 23.

PMID:
18812321
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Endoplasmic reticulum degradation. Reverse protein transport and its end in the proteasome.

Plemper RK, Wolf DH.

Mol Biol Rep. 1999 Apr;26(1-2):125-30.

PMID:
10363658
[PubMed - indexed for MEDLINE]
7.

Use of modular substrates demonstrates mechanistic diversity and reveals differences in chaperone requirement of ERAD.

Taxis C, Hitt R, Park SH, Deak PM, Kostova Z, Wolf DH.

J Biol Chem. 2003 Sep 19;278(38):35903-13. Epub 2003 Jul 7.

PMID:
12847107
[PubMed - indexed for MEDLINE]
Free Article
8.

Inhibiting endoplasmic reticulum (ER)-associated degradation of misfolded Yor1p does not permit ER export despite the presence of a diacidic sorting signal.

Pagant S, Kung L, Dorrington M, Lee MC, Miller EA.

Mol Biol Cell. 2007 Sep;18(9):3398-413. Epub 2007 Jul 5.

PMID:
17615300
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway.

Hiller MM, Finger A, Schweiger M, Wolf DH.

Science. 1996 Sep 20;273(5282):1725-8.

PMID:
8781238
[PubMed - indexed for MEDLINE]
10.

The Type II Hsp40 Sis1 cooperates with Hsp70 and the E3 ligase Ubr1 to promote degradation of terminally misfolded cytosolic protein.

Summers DW, Wolfe KJ, Ren HY, Cyr DM.

PLoS One. 2013;8(1):e52099. doi: 10.1371/journal.pone.0052099. Epub 2013 Jan 16.

PMID:
23341891
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Ubiquitin conjugation triggers misfolded protein sequestration into quality control foci when Hsp70 chaperone levels are limiting.

Shiber A, Breuer W, Brandeis M, Ravid T.

Mol Biol Cell. 2013 Jul;24(13):2076-87. doi: 10.1091/mbc.E13-01-0010. Epub 2013 May 1.

PMID:
23637465
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.

Stolz A, Wolf DH.

Biochim Biophys Acta. 2010 Jun;1803(6):694-705. doi: 10.1016/j.bbamcr.2010.02.005. Epub 2010 Feb 25. Review.

PMID:
20219571
[PubMed - indexed for MEDLINE]
Free Article
13.

Roles of cytosolic Hsp70 and Hsp40 molecular chaperones in post-translational translocation of presecretory proteins into the endoplasmic reticulum.

Ngosuwan J, Wang NM, Fung KL, Chirico WJ.

J Biol Chem. 2003 Feb 28;278(9):7034-42. Epub 2002 Dec 19.

PMID:
12493732
[PubMed - indexed for MEDLINE]
Free Article
14.

Ubiquitin ligase Hul5 is required for fragment-specific substrate degradation in endoplasmic reticulum-associated degradation.

Kohlmann S, Schäfer A, Wolf DH.

J Biol Chem. 2008 Jun 13;283(24):16374-83. doi: 10.1074/jbc.M801702200. Epub 2008 Apr 24.

PMID:
18436532
[PubMed - indexed for MEDLINE]
Free Article
15.

Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins.

Bordallo J, Plemper RK, Finger A, Wolf DH.

Mol Biol Cell. 1998 Jan;9(1):209-22.

PMID:
9437001
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Genetic interactions of Hrd3p and Der3p/Hrd1p with Sec61p suggest a retro-translocation complex mediating protein transport for ER degradation.

Plemper RK, Bordallo J, Deak PM, Taxis C, Hitt R, Wolf DH.

J Cell Sci. 1999 Nov;112 ( Pt 22):4123-34.

PMID:
10547371
[PubMed - indexed for MEDLINE]
Free Article
17.

Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation.

Plemper RK, Böhmler S, Bordallo J, Sommer T, Wolf DH.

Nature. 1997 Aug 28;388(6645):891-5.

PMID:
9278052
[PubMed - indexed for MEDLINE]
18.

The ubiquitin ligase E6-AP is induced and recruited to aggresomes in response to proteasome inhibition and may be involved in the ubiquitination of Hsp70-bound misfolded proteins.

Mishra A, Godavarthi SK, Maheshwari M, Goswami A, Jana NR.

J Biol Chem. 2009 Apr 17;284(16):10537-45. doi: 10.1074/jbc.M806804200. Epub 2009 Feb 20.

PMID:
19233847
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

The requirement for molecular chaperones during endoplasmic reticulum-associated protein degradation demonstrates that protein export and import are mechanistically distinct.

Brodsky JL, Werner ED, Dubas ME, Goeckeler JL, Kruse KB, McCracken AA.

J Biol Chem. 1999 Feb 5;274(6):3453-60.

PMID:
9920890
[PubMed - indexed for MEDLINE]
Free Article

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