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Kaposi sarcoma herpesvirus-encoded vFLIP and vIRF1 regulate antigen presentation in lymphatic endothelial cells.

Lagos D, Trotter MW, Vart RJ, Wang HW, Matthews NC, Hansen A, Flore O, Gotch F, Boshoff C.

Blood. 2007 Feb 15;109(4):1550-8. Epub 2006 Oct 17.


Role of IRF4 in IFN-stimulated gene induction and maintenance of Kaposi sarcoma-associated herpesvirus latency in primary effusion lymphoma cells.

Forero A, Moore PS, Sarkar SN.

J Immunol. 2013 Aug 1;191(3):1476-85. doi: 10.4049/jimmunol.1202514. Epub 2013 Jun 26.


Deletion of Kaposi's sarcoma-associated herpesvirus FLICE inhibitory protein, vFLIP, from the viral genome compromises the activation of STAT1-responsive cellular genes and spindle cell formation in endothelial cells.

Alkharsah KR, Singh VV, Bosco R, Santag S, Grundhoff A, Konrad A, Stürzl M, Wirth D, Dittrich-Breiholz O, Kracht M, Schulz TF.

J Virol. 2011 Oct;85(19):10375-88. doi: 10.1128/JVI.00226-11. Epub 2011 Jul 27.


Induction of CCL20 production by Kaposi sarcoma-associated herpesvirus: role of viral FLICE inhibitory protein K13-induced NF-kappaB activation.

Punj V, Matta H, Schamus S, Yang T, Chang Y, Chaudhary PM.

Blood. 2009 May 28;113(22):5660-8. doi: 10.1182/blood-2008-10-186403. Epub 2009 Mar 26.


Kaposi's sarcoma-associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 suppresses CXCR4 expression by upregulating miR-146a.

Punj V, Matta H, Schamus S, Tamewitz A, Anyang B, Chaudhary PM.

Oncogene. 2010 Mar 25;29(12):1835-44. doi: 10.1038/onc.2009.460. Epub 2009 Dec 21.


A20/TNFAIP3 inhibits NF-κB activation induced by the Kaposi's sarcoma-associated herpesvirus vFLIP oncoprotein.

Sakakibara S, Espigol-Frigole G, Gasperini P, Uldrick TS, Yarchoan R, Tosato G.

Oncogene. 2013 Mar 7;32(10):1223-32. doi: 10.1038/onc.2012.145. Epub 2012 Apr 23.


A20 is induced by Kaposi sarcoma-associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 and blocks K13-induced nuclear factor-kappaB in a negative feedback manner.

Matta H, Gopalakrishnan R, Punj V, Yi H, Suo Y, Chaudhary PM.

J Biol Chem. 2011 Jun 17;286(24):21555-64. doi: 10.1074/jbc.M111.224048. Epub 2011 Apr 29.


Kaposi's sarcoma-associated herpesvirus inhibits expression and function of endothelial cell major histocompatibility complex class II via suppressor of cytokine signaling 3.

Butler LM, Jeffery HC, Wheat RL, Long HM, Rae PC, Nash GB, Blackbourn DJ.

J Virol. 2012 Jul;86(13):7158-66. doi: 10.1128/JVI.06908-11. Epub 2012 Apr 24.


Gene regulation and functional alterations induced by Kaposi's sarcoma-associated herpesvirus-encoded ORFK13/vFLIP in endothelial cells.

Sakakibara S, Pise-Masison CA, Brady JN, Tosato G.

J Virol. 2009 Mar;83(5):2140-53. doi: 10.1128/JVI.01871-08. Epub 2008 Dec 17.


Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 1 Interacts with a Member of the Interferon-Stimulated Gene 15 Pathway.

Jacobs SR, Stopford CM, West JA, Bennett CL, Giffin L, Damania B.

J Virol. 2015 Nov;89(22):11572-83. doi: 10.1128/JVI.01482-15. Epub 2015 Sep 9.


The viral interferon regulatory factors of kaposi's sarcoma-associated herpesvirus differ in their inhibition of interferon activation mediated by toll-like receptor 3.

Jacobs SR, Gregory SM, West JA, Wollish AC, Bennett CL, Blackbourn DJ, Heise MT, Damania B.

J Virol. 2013 Jan;87(2):798-806. doi: 10.1128/JVI.01851-12. Epub 2012 Oct 31.


vFLIP from KSHV inhibits anoikis of primary endothelial cells.

Efklidou S, Bailey R, Field N, Noursadeghi M, Collins MK.

J Cell Sci. 2008 Feb 15;121(Pt 4):450-7. doi: 10.1242/jcs.022343. Epub 2008 Jan 22.


The manipulation of miRNA-gene regulatory networks by KSHV induces endothelial cell motility.

Wu YH, Hu TF, Chen YC, Tsai YN, Tsai YH, Cheng CC, Wang HW.

Blood. 2011 Sep 8;118(10):2896-905. doi: 10.1182/blood-2011-01-330589. Epub 2011 Jun 28.


KSHV RTA abolishes NFκB responsive gene expression during lytic reactivation by targeting vFLIP for degradation via the proteasome.

Ehrlich ES, Chmura JC, Smith JC, Kalu NN, Hayward GS.

PLoS One. 2014 Mar 10;9(3):e91359. doi: 10.1371/journal.pone.0091359. eCollection 2014.

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