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Results: 1 to 20 of 99

1.

Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters.

Zheng G, Horton DB, Deaciuc AG, Dwoskin LP, Crooks PA.

Bioorg Med Chem Lett. 2006 Oct 1;16(19):5018-21. Epub 2006 Aug 14.

PMID:
16905316
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Lobeline analogs with enhanced affinity and selectivity for plasmalemma and vesicular monoamine transporters.

Miller DK, Crooks PA, Zheng G, Grinevich VP, Norrholm SD, Dwoskin LP.

J Pharmacol Exp Ther. 2004 Sep;310(3):1035-45. Epub 2004 Apr 30.

PMID:
15121762
[PubMed - indexed for MEDLINE]
Free Article
3.

Lobeline esters as novel ligands for neuronal nicotinic acetylcholine receptors and neurotransmitter transporters.

Hojahmat M, Horton DB, Norrholm SD, Miller DK, Grinevich VP, Deaciuc AG, Dwoskin LP, Crooks PA.

Bioorg Med Chem. 2010 Jan 15;18(2):640-9. doi: 10.1016/j.bmc.2009.12.002. Epub 2009 Dec 6.

PMID:
20036131
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Defunctionalized lobeline analogues: structure-activity of novel ligands for the vesicular monoamine transporter.

Zheng G, Dwoskin LP, Deaciuc AG, Norrholm SD, Crooks PA.

J Med Chem. 2005 Aug 25;48(17):5551-60.

PMID:
16107155
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Lobelane inhibits methamphetamine-evoked dopamine release via inhibition of the vesicular monoamine transporter-2.

Nickell JR, Krishnamurthy S, Norrholm S, Deaciuc G, Siripurapu KB, Zheng G, Crooks PA, Dwoskin LP.

J Pharmacol Exp Ther. 2010 Feb;332(2):612-21. doi: 10.1124/jpet.109.160275. Epub 2009 Oct 23.

PMID:
19855096
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Novel N-1,2-dihydroxypropyl analogs of lobelane inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release.

Horton DB, Siripurapu KB, Zheng G, Crooks PA, Dwoskin LP.

J Pharmacol Exp Ther. 2011 Oct;339(1):286-97. doi: 10.1124/jpet.111.184770. Epub 2011 Jul 21.

PMID:
21778282
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

meso-Transdiene analogs inhibit vesicular monoamine transporter-2 function and methamphetamine-evoked dopamine release.

Horton DB, Siripurapu KB, Norrholm SD, Culver JP, Hojahmat M, Beckmann JS, Harrod SB, Deaciuc AG, Bardo MT, Crooks PA, Dwoskin LP.

J Pharmacol Exp Ther. 2011 Mar;336(3):940-51. doi: 10.1124/jpet.110.175117. Epub 2010 Dec 21.

PMID:
21177475
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Phenyl ring-substituted lobelane analogs: inhibition of [³H]dopamine uptake at the vesicular monoamine transporter-2.

Nickell JR, Zheng G, Deaciuc AG, Crooks PA, Dwoskin LP.

J Pharmacol Exp Ther. 2011 Mar;336(3):724-33. doi: 10.1124/jpet.110.172882. Epub 2010 Sep 28.

PMID:
20876747
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Design, synthesis and interaction at the vesicular monoamine transporter-2 of lobeline analogs: potential pharmacotherapies for the treatment of psychostimulant abuse.

Crooks PA, Zheng G, Vartak AP, Culver JP, Zheng F, Horton DB, Dwoskin LP.

Curr Top Med Chem. 2011;11(9):1103-27. Review.

PMID:
21050177
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

The novel pyrrolidine nor-lobelane analog UKCP-110 [cis-2,5-di-(2-phenethyl)-pyrrolidine hydrochloride] inhibits VMAT2 function, methamphetamine-evoked dopamine release, and methamphetamine self-administration in rats.

Beckmann JS, Siripurapu KB, Nickell JR, Horton DB, Denehy ED, Vartak A, Crooks PA, Dwoskin LP, Bardo MT.

J Pharmacol Exp Ther. 2010 Dec;335(3):841-51. doi: 10.1124/jpet.110.172742. Epub 2010 Aug 30.

PMID:
20805303
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Lobeline effects on tonic and methamphetamine-induced dopamine release.

Wilhelm CJ, Johnson RA, Eshleman AJ, Janowsky A.

Biochem Pharmacol. 2008 Mar 15;75(6):1411-5. doi: 10.1016/j.bcp.2007.11.019. Epub 2007 Dec 4.

PMID:
18191815
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Pyrrolidine analogs of GZ-793A: synthesis and evaluation as inhibitors of the vesicular monoamine transporter-2 (VMAT2).

Penthala NR, Ponugoti PR, Nickell JR, Deaciuc AG, Dwoskin LP, Crooks PA.

Bioorg Med Chem Lett. 2013 Jun 1;23(11):3342-5. doi: 10.1016/j.bmcl.2013.03.092. Epub 2013 Apr 2.

PMID:
23597792
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Synthesis and evaluation of a series of homologues of lobelane at the vesicular monoamine transporter-2.

Zheng G, Dwoskin LP, Deaciuc AG, Crooks PA.

Bioorg Med Chem Lett. 2008 Dec 15;18(24):6509-12. doi: 10.1016/j.bmcl.2008.10.042. Epub 2008 Oct 14.

PMID:
18976906
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Lobelane analogues as novel ligands for the vesicular monoamine transporter-2.

Zheng G, Dwoskin LP, Deaciuc AG, Zhu J, Jones MD, Crooks PA.

Bioorg Med Chem. 2005 Jun 2;13(12):3899-909.

PMID:
15911306
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Introduction of unsaturation into the N-n-alkyl chain of the nicotinic receptor antagonists, NONI and NDNI: effect on affinity and selectivity.

Sumithran SP, Crooks PA, Xu R, Zhu J, Deaciuc AG, Wilkins LH, Dwoskin LP.

AAPS J. 2005 Aug 29;7(1):E201-17.

PMID:
16146341
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Lobeline displaces [3H]dihydrotetrabenazine binding and releases [3H]dopamine from rat striatal synaptic vesicles: comparison with d-amphetamine.

Teng L, Crooks PA, Dwoskin LP.

J Neurochem. 1998 Jul;71(1):258-65.

PMID:
9648873
[PubMed - indexed for MEDLINE]
20.

MDMA (Ecstasy) and human dopamine, norepinephrine, and serotonin transporters: implications for MDMA-induced neurotoxicity and treatment.

Verrico CD, Miller GM, Madras BK.

Psychopharmacology (Berl). 2007 Jan;189(4):489-503. Epub 2005 Oct 12.

PMID:
16220332
[PubMed - indexed for MEDLINE]

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