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Items: 1 to 20 of 295

1.

Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease.

Anderson JP, Walker DE, Goldstein JM, de Laat R, Banducci K, Caccavello RJ, Barbour R, Huang J, Kling K, Lee M, Diep L, Keim PS, Shen X, Chataway T, Schlossmacher MG, Seubert P, Schenk D, Sinha S, Gai WP, Chilcote TJ.

J Biol Chem. 2006 Oct 6;281(40):29739-52. Epub 2006 Jul 17.

2.

Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function.

Tofaris GK, Razzaq A, Ghetti B, Lilley KS, Spillantini MG.

J Biol Chem. 2003 Nov 7;278(45):44405-11. Epub 2003 Aug 15.

3.

Brain alpha-synuclein accumulation in multiple system atrophy, Parkinson's disease and progressive supranuclear palsy: a comparative investigation.

Tong J, Wong H, Guttman M, Ang LC, Forno LS, Shimadzu M, Rajput AH, Muenter MD, Kish SJ, Hornykiewicz O, Furukawa Y.

Brain. 2010 Jan;133(Pt 1):172-88. doi: 10.1093/brain/awp282. Epub 2009 Nov 10.

4.

α-synuclein phosphorylation and truncation are normal events in the adult human brain.

Muntané G, Ferrer I, Martinez-Vicente M.

Neuroscience. 2012 Jan 3;200:106-19. doi: 10.1016/j.neuroscience.2011.10.042. Epub 2011 Oct 29.

PMID:
22079575
5.

Clinical and biochemical correlates of insoluble alpha-synuclein in dementia with Lewy bodies.

Klucken J, Ingelsson M, Shin Y, Irizarry MC, Hedley-Whyte ET, Frosch M, Growdon J, McLean P, Hyman BT.

Acta Neuropathol. 2006 Feb;111(2):101-8. Epub 2006 Feb 16.

PMID:
16482476
6.

[Clinical and pathological study on early diagnosis of Parkinson's disease and dementia with Lewy bodies].

Orimo S.

Rinsho Shinkeigaku. 2008 Jan;48(1):11-24. Review. Japanese.

PMID:
18386627
7.

Accumulation of NACP/alpha-synuclein in lewy body disease and multiple system atrophy.

Shoji M, Harigaya Y, Sasaki A, Uéda K, Ishiguro K, Matsubara E, Watanabe M, Ikeda M, Kanai M, Tomidokoro Y, Shizuka M, Amari M, Kosaka K, Nakazato Y, Okamoto K, Hirai S.

J Neurol Neurosurg Psychiatry. 2000 May;68(5):605-8.

8.

Neuropathological spectrum of synucleinopathies.

Jellinger KA.

Mov Disord. 2003 Sep;18 Suppl 6:S2-12. Review.

PMID:
14502650
9.

Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease.

Kaneko H, Kakita A, Kasuga K, Nozaki H, Ishikawa A, Miyashita A, Kuwano R, Ito G, Iwatsubo T, Takahashi H, Nishizawa M, Onodera O, Sisodia SS, Ikeuchi T.

J Neurosci. 2007 Nov 28;27(48):13092-7.

10.

Transgenic mice overexpressing tyrosine-to-cysteine mutant human alpha-synuclein: a progressive neurodegenerative model of diffuse Lewy body disease.

Zhou W, Milder JB, Freed CR.

J Biol Chem. 2008 Apr 11;283(15):9863-70. doi: 10.1074/jbc.M710232200. Epub 2008 Jan 30.

11.

Nuclear and neuritic distribution of serine-129 phosphorylated alpha-synuclein in transgenic mice.

Schell H, Hasegawa T, Neumann M, Kahle PJ.

Neuroscience. 2009 Jun 2;160(4):796-804. doi: 10.1016/j.neuroscience.2009.03.002. Epub 2009 Mar 9.

PMID:
19272424
12.

Proteinase K-resistant alpha-synuclein is deposited in presynapses in human Lewy body disease and A53T alpha-synuclein transgenic mice.

Tanji K, Mori F, Mimura J, Itoh K, Kakita A, Takahashi H, Wakabayashi K.

Acta Neuropathol. 2010 Aug;120(2):145-54. doi: 10.1007/s00401-010-0676-z. Epub 2010 Mar 26.

PMID:
20339856
13.

Abundant neuritic inclusions and microvacuolar changes in a case of diffuse Lewy body disease with the A53T mutation in the alpha-synuclein gene.

Yamaguchi K, Cochran EJ, Murrell JR, Polymeropoulos MH, Shannon KM, Crowther RA, Goedert M, Ghetti B.

Acta Neuropathol. 2005 Sep;110(3):298-305. Epub 2005 Jun 25.

PMID:
15981014
14.

Early alpha-synuclein lipoxidation in neocortex in Lewy body diseases.

Dalfó E, Ferrer I.

Neurobiol Aging. 2008 Mar;29(3):408-17. Epub 2006 Dec 12.

PMID:
17166629
15.

Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions.

McFarland MA, Ellis CE, Markey SP, Nussbaum RL.

Mol Cell Proteomics. 2008 Nov;7(11):2123-37. doi: 10.1074/mcp.M800116-MCP200. Epub 2008 Jul 9.

16.
17.

Ubiquitination of alpha-synuclein by Siah-1 promotes alpha-synuclein aggregation and apoptotic cell death.

Lee JT, Wheeler TC, Li L, Chin LS.

Hum Mol Genet. 2008 Mar 15;17(6):906-17. Epub 2007 Dec 7.

18.

alpha-Synuclein is phosphorylated in synucleinopathy lesions.

Fujiwara H, Hasegawa M, Dohmae N, Kawashima A, Masliah E, Goldberg MS, Shen J, Takio K, Iwatsubo T.

Nat Cell Biol. 2002 Feb;4(2):160-4.

PMID:
11813001
19.

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia.

Zarranz JJ, Alegre J, Gómez-Esteban JC, Lezcano E, Ros R, Ampuero I, Vidal L, Hoenicka J, Rodriguez O, Atarés B, Llorens V, Gomez Tortosa E, del Ser T, Muñoz DG, de Yebenes JG.

Ann Neurol. 2004 Feb;55(2):164-73.

PMID:
14755719
20.

Relationship of phosphorylated alpha-synuclein and tau accumulation to Abeta deposition in the cerebral cortex of dementia with Lewy bodies.

Obi K, Akiyama H, Kondo H, Shimomura Y, Hasegawa M, Iwatsubo T, Mizuno Y, Mochizuki H.

Exp Neurol. 2008 Apr;210(2):409-20. doi: 10.1016/j.expneurol.2007.11.019. Epub 2007 Dec 3.

PMID:
18164295
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