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Items: 1 to 20 of 108


Requirement of Nck adaptors for actin dynamics and cell migration stimulated by platelet-derived growth factor B.

Rivera GM, Antoku S, Gelkop S, Shin NY, Hanks SK, Pawson T, Mayer BJ.

Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9536-41. Epub 2006 Jun 12.


Distinct roles for Crk adaptor isoforms in actin reorganization induced by extracellular signals.

Antoku S, Mayer BJ.

J Cell Sci. 2009 Nov 15;122(Pt 22):4228-38. doi: 10.1242/jcs.054627. Epub 2009 Oct 27.


Inducible clustering of membrane-targeted SH3 domains of the adaptor protein Nck triggers localized actin polymerization.

Rivera GM, Briceño CA, Takeshima F, Snapper SB, Mayer BJ.

Curr Biol. 2004 Jan 6;14(1):11-22.


Nck adapters are involved in the formation of dorsal ruffles, cell migration, and Rho signaling downstream of the platelet-derived growth factor beta receptor.

Ruusala A, Pawson T, Heldin CH, Aspenström P.

J Biol Chem. 2008 Oct 31;283(44):30034-44. doi: 10.1074/jbc.M800913200. Epub 2008 Sep 2.


Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes.

Jones N, Blasutig IM, Eremina V, Ruston JM, Bladt F, Li H, Huang H, Larose L, Li SS, Takano T, Quaggin SE, Pawson T.

Nature. 2006 Apr 6;440(7085):818-23. Epub 2006 Mar 8.


SDF1α-induced interaction of the adapter proteins Nck and HS1 facilitates actin polymerization and migration in T cells.

Lettau M, Kabelitz D, Janssen O.

Eur J Immunol. 2015 Feb;45(2):551-61. doi: 10.1002/eji.201444473. Epub 2014 Nov 28.


A reciprocal interdependence between Nck and PI(4,5)P(2) promotes localized N-WASp-mediated actin polymerization in living cells.

Rivera GM, Vasilescu D, Papayannopoulos V, Lim WA, Mayer BJ.

Mol Cell. 2009 Nov 13;36(3):525-35. doi: 10.1016/j.molcel.2009.10.025.


Phosphorylated YDXV motifs and Nck SH2/SH3 adaptors act cooperatively to induce actin reorganization.

Blasutig IM, New LA, Thanabalasuriar A, Dayarathna TK, Goudreault M, Quaggin SE, Li SS, Gruenheid S, Jones N, Pawson T.

Mol Cell Biol. 2008 Mar;28(6):2035-46. doi: 10.1128/MCB.01770-07. Epub 2008 Jan 22.


Nck/Dock: an adapter between cell surface receptors and the actin cytoskeleton.

Li W, Fan J, Woodley DT.

Oncogene. 2001 Oct 1;20(44):6403-17. Review.


Direct regulation of nephrin tyrosine phosphorylation by Nck adaptor proteins.

New LA, Keyvani Chahi A, Jones N.

J Biol Chem. 2013 Jan 18;288(3):1500-10. doi: 10.1074/jbc.M112.439463. Epub 2012 Nov 27.


Nck adaptor proteins link Tks5 to invadopodia actin regulation and ECM degradation.

Stylli SS, Stacey TT, Verhagen AM, Xu SS, Pass I, Courtneidge SA, Lock P.

J Cell Sci. 2009 Aug 1;122(Pt 15):2727-40. doi: 10.1242/jcs.046680. Epub 2009 Jul 13.


The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network.

Bladt F, Aippersbach E, Gelkop S, Strasser GA, Nash P, Tafuri A, Gertler FB, Pawson T.

Mol Cell Biol. 2003 Jul;23(13):4586-97.


Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor.

Nishimura R, Li W, Kashishian A, Mondino A, Zhou M, Cooper J, Schlessinger J.

Mol Cell Biol. 1993 Nov;13(11):6889-96.

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