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Results: 1 to 20 of 386

1.

Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance.

Gutiérrez-Juárez R, Pocai A, Mulas C, Ono H, Bhanot S, Monia BP, Rossetti L.

J Clin Invest. 2006 Jun;116(6):1686-95.

PMID:
16741579
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Gene expression profiling in skeletal muscle of Zucker diabetic fatty rats: implications for a role of stearoyl-CoA desaturase 1 in insulin resistance.

Voss MD, Beha A, Tennagels N, Tschank G, Herling AW, Quint M, Gerl M, Metz-Weidmann C, Haun G, Korn M.

Diabetologia. 2005 Dec;48(12):2622-30. Epub 2005 Nov 12.

PMID:
16284748
[PubMed - indexed for MEDLINE]
3.

Probing the role of stearoyl-CoA desaturase-1 in hepatic insulin resistance.

Flowers MT, Miyazaki M, Liu X, Ntambi JM.

J Clin Invest. 2006 Jun;116(6):1478-81.

PMID:
16741573
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Role of resistin in diet-induced hepatic insulin resistance.

Muse ED, Obici S, Bhanot S, Monia BP, McKay RA, Rajala MW, Scherer PE, Rossetti L.

J Clin Invest. 2004 Jul;114(2):232-9.

PMID:
15254590
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Low hepatic stearoyl-CoA desaturase 1 activity is associated with fatty liver and insulin resistance in obese humans.

Stefan N, Peter A, Cegan A, Staiger H, Machann J, Schick F, Claussen CD, Fritsche A, Häring HU, Schleicher E.

Diabetologia. 2008 Apr;51(4):648-56. doi: 10.1007/s00125-008-0938-7. Epub 2008 Feb 20.

PMID:
18286258
[PubMed - indexed for MEDLINE]
6.

Dietary regulation of stearoyl-CoA desaturase 1 gene expression in mouse liver.

Ntambi JM.

J Biol Chem. 1992 May 25;267(15):10925-30.

PMID:
1350282
[PubMed - indexed for MEDLINE]
Free Article
7.

Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice.

Flowers JB, Rabaglia ME, Schueler KL, Flowers MT, Lan H, Keller MP, Ntambi JM, Attie AD.

Diabetes. 2007 May;56(5):1228-39. Epub 2007 Mar 16.

PMID:
17369521
[PubMed - indexed for MEDLINE]
Free Article
8.

Down-regulation of hepatic stearoyl-CoA desaturase 1 expression by angiotensin II receptor blocker in the obese fa/fa Zucker rat: possible role in amelioration of insulin resistance and hepatic steatosis.

Yokozawa J, Sasaki T, Ohwada K, Sasaki Y, Ito JI, Saito T, Kawata S.

J Gastroenterol. 2009;44(6):583-91. doi: 10.1007/s00535-009-0042-x. Epub 2009 Apr 14.

PMID:
19365601
[PubMed - indexed for MEDLINE]
9.

Pharmacological inhibition of stearoyl-CoA desaturase 1 improves insulin sensitivity in insulin-resistant rat models.

Issandou M, Bouillot A, Brusq JM, Forest MC, Grillot D, Guillard R, Martin S, Michiels C, Sulpice T, Daugan A.

Eur J Pharmacol. 2009 Sep 15;618(1-3):28-36. doi: 10.1016/j.ejphar.2009.07.004. Epub 2009 Jul 17.

PMID:
19616540
[PubMed - indexed for MEDLINE]
10.

Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1.

Jiang G, Li Z, Liu F, Ellsworth K, Dallas-Yang Q, Wu M, Ronan J, Esau C, Murphy C, Szalkowski D, Bergeron R, Doebber T, Zhang BB.

J Clin Invest. 2005 Apr;115(4):1030-8. Epub 2005 Mar 10. Erratum in: J Clin Invest. 2005 Aug;115(8):2297.

PMID:
15761499
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Recent insights into stearoyl-CoA desaturase-1.

Ntambi JM, Miyazaki M.

Curr Opin Lipidol. 2003 Jun;14(3):255-61. Review.

PMID:
12840656
[PubMed - indexed for MEDLINE]
12.

Stearoyl CoA desaturase 1 is elevated in obesity but protects against fatty acid-induced skeletal muscle insulin resistance in vitro.

Pinnamaneni SK, Southgate RJ, Febbraio MA, Watt MJ.

Diabetologia. 2006 Dec;49(12):3027-37. Epub 2006 Oct 11. Erratum in: Diabetologia. 2010 Jan;53(1):219.

PMID:
17033839
[PubMed - indexed for MEDLINE]
13.

Dietary cholesterol opposes PUFA-mediated repression of the stearoyl-CoA desaturase-1 gene by SREBP-1 independent mechanism.

Kim HJ, Miyazaki M, Ntambi JM.

J Lipid Res. 2002 Oct;43(10):1750-7.

PMID:
12364560
[PubMed - indexed for MEDLINE]
Free Article
14.

Prominent role of liver in elevated plasma palmitoleate levels in response to rosiglitazone in mice fed high-fat diet.

Kuda O, Stankova B, Tvrzicka E, Hensler M, Jelenik T, Rossmeisl M, Flachs P, Kopecky J.

J Physiol Pharmacol. 2009 Dec;60(4):135-40.

PMID:
20065507
[PubMed - indexed for MEDLINE]
Free Article
15.

Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity.

Sampath H, Flowers MT, Liu X, Paton CM, Sullivan R, Chu K, Zhao M, Ntambi JM.

J Biol Chem. 2009 Jul 24;284(30):19961-73. doi: 10.1074/jbc.M109.014225. Epub 2009 May 8.

PMID:
19429677
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis.

Miyazaki M, Flowers MT, Sampath H, Chu K, Otzelberger C, Liu X, Ntambi JM.

Cell Metab. 2007 Dec;6(6):484-96.

PMID:
18054317
[PubMed - indexed for MEDLINE]
Free Article
17.

Stearoyl-CoA desaturase and insulin signaling--what is the molecular switch?

Dobrzyn P, Jazurek M, Dobrzyn A.

Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):1189-94. doi: 10.1016/j.bbabio.2010.02.007. Epub 2010 Feb 10. Review.

PMID:
20153289
[PubMed - indexed for MEDLINE]
Free Article
18.

Reduced adiposity and liver steatosis by stearoyl-CoA desaturase deficiency are independent of peroxisome proliferator-activated receptor-alpha.

Miyazaki M, Dobrzyn A, Sampath H, Lee SH, Man WC, Chu K, Peters JM, Gonzalez FJ, Ntambi JM.

J Biol Chem. 2004 Aug 13;279(33):35017-24. Epub 2004 Jun 4.

PMID:
15180999
[PubMed - indexed for MEDLINE]
Free Article
19.

Reduced adiposity and improved insulin sensitivity in obese mice with antisense suppression of 4E-BP2 expression.

Yu XX, Pandey SK, Booten SL, Murray SF, Monia BP, Bhanot S.

Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E530-9. doi: 10.1152/ajpendo.00350.2007. Epub 2008 Jan 15.

PMID:
18198353
[PubMed - indexed for MEDLINE]
Free Article
20.

Monounsaturated fatty acids generated via stearoyl CoA desaturase-1 are endogenous inhibitors of fatty acid amide hydrolase.

Liu J, Cinar R, Xiong K, Godlewski G, Jourdan T, Lin Y, Ntambi JM, Kunos G.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18832-7. doi: 10.1073/pnas.1309469110. Epub 2013 Nov 4.

PMID:
24191036
[PubMed - indexed for MEDLINE]
Free PMC Article

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