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Results: 1 to 20 of 140

1.

CUTLL1, a novel human T-cell lymphoma cell line with t(7;9) rearrangement, aberrant NOTCH1 activation and high sensitivity to gamma-secretase inhibitors.

Palomero T, Barnes KC, Real PJ, Glade Bender JL, Sulis ML, Murty VV, Colovai AI, Balbin M, Ferrando AA.

Leukemia. 2006 Jul;20(7):1279-87. Epub 2006 May 11.

PMID:
16688224
[PubMed - indexed for MEDLINE]
2.

In vitro validation of gamma-secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia.

De Keersmaecker K, Lahortiga I, Mentens N, Folens C, Van Neste L, Bekaert S, Vandenberghe P, Odero MD, Marynen P, Cools J.

Haematologica. 2008 Apr;93(4):533-42. doi: 10.3324/haematol.11894. Epub 2008 Mar 5.

PMID:
18322257
[PubMed - indexed for MEDLINE]
Free Article
3.

New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia.

Hales EC, Taub JW, Matherly LH.

Cell Signal. 2014 Jan;26(1):149-61. doi: 10.1016/j.cellsig.2013.09.021. Epub 2013 Oct 16. Review.

PMID:
24140475
[PubMed - indexed for MEDLINE]
4.

Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells.

Rao SS, O'Neil J, Liberator CD, Hardwick JS, Dai X, Zhang T, Tyminski E, Yuan J, Kohl NE, Richon VM, Van der Ploeg LH, Carroll PM, Draetta GF, Look AT, Strack PR, Winter CG.

Cancer Res. 2009 Apr 1;69(7):3060-8. doi: 10.1158/0008-5472.CAN-08-4295. Epub 2009 Mar 24.

PMID:
19318552
[PubMed - indexed for MEDLINE]
Free Article
5.

Regulation of PTEN by CK2 and Notch1 in primary T-cell acute lymphoblastic leukemia: rationale for combined use of CK2- and gamma-secretase inhibitors.

Silva A, Jotta PY, Silveira AB, Ribeiro D, Brandalise SR, Yunes JA, Barata JT.

Haematologica. 2010 Apr;95(4):674-8. doi: 10.3324/haematol.2009.011999. Epub 2009 Dec 16.

PMID:
20015880
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Gamma-secretase inhibitors suppress the growth of leukemia and lymphoma cells.

Kogoshi H, Sato T, Koyama T, Nara N, Tohda S.

Oncol Rep. 2007 Jul;18(1):77-80.

PMID:
17549349
[PubMed - indexed for MEDLINE]
7.

T cell acute lymphoblastic leukemia/lymphoma: a human cancer commonly associated with aberrant NOTCH1 signaling.

Pear WS, Aster JC.

Curr Opin Hematol. 2004 Nov;11(6):426-33. Review.

PMID:
15548998
[PubMed - indexed for MEDLINE]
8.

Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia.

Pancewicz J, Taylor JM, Datta A, Baydoun HH, Waldmann TA, Hermine O, Nicot C.

Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16619-24. doi: 10.1073/pnas.1010722107. Epub 2010 Sep 7.

PMID:
20823234
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Targeting the Notch1 and mTOR pathways in a mouse T-ALL model.

Cullion K, Draheim KM, Hermance N, Tammam J, Sharma VM, Ware C, Nikov G, Krishnamoorthy V, Majumder PK, Kelliher MA.

Blood. 2009 Jun 11;113(24):6172-81. doi: 10.1182/blood-2008-02-136762. Epub 2009 Feb 26.

PMID:
19246562
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Downregulation of Notch signaling by gamma-secretase inhibition can abrogate chemotherapy-induced apoptosis in T-ALL cell lines.

Liu S, Breit S, Danckwardt S, Muckenthaler MU, Kulozik AE.

Ann Hematol. 2009 Jul;88(7):613-21. doi: 10.1007/s00277-008-0646-x. Epub 2008 Dec 5.

PMID:
19057901
[PubMed - indexed for MEDLINE]
11.

Recent advances on NOTCH signaling in T-ALL.

Tzoneva G, Ferrando AA.

Curr Top Microbiol Immunol. 2012;360:163-82. doi: 10.1007/82_2012_232. Review.

PMID:
22673746
[PubMed - indexed for MEDLINE]
12.

A novel TRB@/NOTCH1 fusion gene in T-cell lymphoblastic lymphoma with t(7;9)(q34;q34).

Yamamoto K, Nakamachi Y, Yakushijin K, Miyata Y, Okamura A, Kawano S, Matsuoka H, Minami H.

Eur J Haematol. 2013 Jan;90(1):68-75. doi: 10.1111/ejh.12019. Epub 2012 Nov 29.

PMID:
23033986
[PubMed - indexed for MEDLINE]
13.

Therapeutic targeting of NOTCH1 signaling in T-cell acute lymphoblastic leukemia.

Palomero T, Ferrando A.

Clin Lymphoma Myeloma. 2009;9 Suppl 3:S205-10. doi: 10.3816/CLM.2009.s.013. Review.

PMID:
19778842
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Inhibition of gamma-secretase affects proliferation of leukemia and hepatoma cell lines through Notch signaling.

Suwanjunee S, Wongchana W, Palaga T.

Anticancer Drugs. 2008 Jun;19(5):477-86. doi: 10.1097/CAD.0b013e3282fc6cdd.

PMID:
18418214
[PubMed - indexed for MEDLINE]
15.

NOTCH1 signaling as a therapeutic target in Sézary syndrome.

van der Fits L, Qin Y, Out-Luiting JJ, Vermeer KG, Whittaker S, van Es JH, Tensen CP, Vermeer MH.

J Invest Dermatol. 2012 Dec;132(12):2810-7. doi: 10.1038/jid.2012.203. Epub 2012 Jun 21.

PMID:
22718117
[PubMed - indexed for MEDLINE]
Free Article
16.

Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia.

Sanda T, Li X, Gutierrez A, Ahn Y, Neuberg DS, O'Neil J, Strack PR, Winter CG, Winter SS, Larson RS, von Boehmer H, Look AT.

Blood. 2010 Mar 4;115(9):1735-45. doi: 10.1182/blood-2009-07-235143. Epub 2009 Dec 9.

PMID:
20007543
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc.

Sharma VM, Calvo JA, Draheim KM, Cunningham LA, Hermance N, Beverly L, Krishnamoorthy V, Bhasin M, Capobianco AJ, Kelliher MA.

Mol Cell Biol. 2006 Nov;26(21):8022-31. Epub 2006 Sep 5.

PMID:
16954387
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

NOTCH1 extracellular juxtamembrane expansion mutations in T-ALL.

Sulis ML, Williams O, Palomero T, Tosello V, Pallikuppam S, Real PJ, Barnes K, Zuurbier L, Meijerink JP, Ferrando AA.

Blood. 2008 Aug 1;112(3):733-40. doi: 10.1182/blood-2007-12-130096. Epub 2008 Apr 14.

PMID:
18411416
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

The role of the PTEN/AKT Pathway in NOTCH1-induced leukemia.

Palomero T, Dominguez M, Ferrando AA.

Cell Cycle. 2008 Apr 15;7(8):965-70. Epub 2008 Feb 19.

PMID:
18414037
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Establishment of a novel B-cell lymphoma cell line with suppressed growth by gamma-secretase inhibitors.

Tohda S, Sato T, Kogoshi H, Fu L, Sakano S, Nara N.

Leuk Res. 2006 Nov;30(11):1385-90. Epub 2006 Jun 14.

PMID:
16780947
[PubMed - indexed for MEDLINE]

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