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Items: 1 to 20 of 120


The multifunctional GIT family of proteins.

Hoefen RJ, Berk BC.

J Cell Sci. 2006 Apr 15;119(Pt 8):1469-75. Review.


The GIT/PIX complex: an oligomeric assembly of GIT family ARF GTPase-activating proteins and PIX family Rac1/Cdc42 guanine nucleotide exchange factors.

Premont RT, Perry SJ, Schmalzigaug R, Roseman JT, Xing Y, Claing A.

Cell Signal. 2004 Sep;16(9):1001-11.


GIT1 functions in a motile, multi-molecular signaling complex that regulates protrusive activity and cell migration.

Manabe R, Kovalenko M, Webb DJ, Horwitz AR.

J Cell Sci. 2002 Apr 1;115(Pt 7):1497-510.


GIT1 activates p21-activated kinase through a mechanism independent of p21 binding.

Loo TH, Ng YW, Lim L, Manser E.

Mol Cell Biol. 2004 May;24(9):3849-59.


Phosphorylation of serine 709 in GIT1 regulates protrusive activity in cells.

Webb DJ, Kovalenko M, Whitmore L, Horwitz AF.

Biochem Biophys Res Commun. 2006 Aug 11;346(4):1284-8. Epub 2006 Jun 14.


Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly.

Zhao ZS, Manser E, Loo TH, Lim L.

Mol Cell Biol. 2000 Sep;20(17):6354-63.


GIT2 represses Crk- and Rac1-regulated cell spreading and Cdc42-mediated focal adhesion turnover.

Frank SR, Adelstein MR, Hansen SH.

EMBO J. 2006 May 3;25(9):1848-59. Epub 2006 Apr 20.


Hic-5 interacts with GIT1 with a different binding mode from paxillin.

Nishiya N, Shirai T, Suzuki W, Nose K.

J Biochem. 2002 Aug;132(2):279-89.


Sorting nexin 27 protein regulates trafficking of a p21-activated kinase (PAK) interacting exchange factor (β-Pix)-G protein-coupled receptor kinase interacting protein (GIT) complex via a PDZ domain interaction.

Valdes JL, Tang J, McDermott MI, Kuo JC, Zimmerman SP, Wincovitch SM, Waterman CM, Milgram SL, Playford MP.

J Biol Chem. 2011 Nov 11;286(45):39403-16. doi: 10.1074/jbc.M111.260802. Epub 2011 Sep 18.


Analysis of the subcellular distribution of avian p95-APP2, an ARF-GAP orthologous to mammalian paxillin kinase linker.

Paris S, Za L, Sporchia B, de Curtis I.

Int J Biochem Cell Biol. 2002 Jul;34(7):826-37.


The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing.

Premont RT, Claing A, Vitale N, Perry SJ, Lefkowitz RJ.

J Biol Chem. 2000 Jul 21;275(29):22373-80.


GIT1 is a scaffold for ERK1/2 activation in focal adhesions.

Yin G, Zheng Q, Yan C, Berk BC.

J Biol Chem. 2005 Jul 29;280(30):27705-12. Epub 2005 May 27.


Characterization of the endogenous GIT1-betaPIX complex, and identification of its association to membranes.

Botrugno OA, Paris S, Za L, Gualdoni S, Cattaneo A, Bachi A, de Curtis I.

Eur J Cell Biol. 2006 Jan;85(1):35-46. Epub 2005 Nov 8.


Endothelin 1 induces beta 1Pix translocation and Cdc42 activation via protein kinase A-dependent pathway.

Chahdi A, Miller B, Sorokin A.

J Biol Chem. 2005 Jan 7;280(1):578-84. Epub 2004 Oct 28.


Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix.

ten Klooster JP, Jaffer ZM, Chernoff J, Hordijk PL.

J Cell Biol. 2006 Feb 27;172(5):759-69. Epub 2006 Feb 21.


GIT1 utilizes a focal adhesion targeting-homology domain to bind paxillin.

Schmalzigaug R, Garron ML, Roseman JT, Xing Y, Davidson CE, Arold ST, Premont RT.

Cell Signal. 2007 Aug;19(8):1733-44. Epub 2007 Mar 30.

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