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Items: 1 to 20 of 118


Anti-GPVI-associated ITP: an acquired platelet disorder caused by autoantibody-mediated clearance of the GPVI/FcRgamma-chain complex from the human platelet surface.

Boylan B, Chen H, Rathore V, Paddock C, Salacz M, Friedman KD, Curtis BR, Stapleton M, Newman DK, Kahn ML, Newman PJ.

Blood. 2004 Sep 1;104(5):1350-5. Epub 2004 May 18.


Evidence for two distinct epitopes within collagen for activation of murine platelets.

Schulte V, Snell D, Bergmeier W, Zirngibl H, Watson SP, Nieswandt B.

J Biol Chem. 2001 Jan 5;276(1):364-8.


Anti-glycoprotein VI monoclonal antibodies directly aggregate platelets independently of FcgammaRIIa and induce GPVI ectodomain shedding.

Al-Tamimi M, Mu FT, Arthur JF, Shen Y, Moroi M, Berndt MC, Andrews RK, Gardiner EE.

Platelets. 2009 Mar;20(2):75-82. doi: 10.1080/09537100802645029.


A novel antiplatelet antibody therapy that induces cAMP-dependent endocytosis of the GPVI/Fc receptor gamma-chain complex.

Takayama H, Hosaka Y, Nakayama K, Shirakawa K, Naitoh K, Matsusue T, Shinozaki M, Honda M, Yatagai Y, Kawahara T, Hirose J, Yokoyama T, Kurihara M, Furusako S.

J Clin Invest. 2008 May;118(5):1785-95. doi: 10.1172/JCI32513.


Adhesion and activation of human platelets induced by convulxin involve glycoprotein VI and integrin alpha2beta1.

Jandrot-Perrus M, Lagrue AH, Okuma M, Bon C.

J Biol Chem. 1997 Oct 24;272(43):27035-41.


Relative antithrombotic effect of soluble GPVI dimer compared with anti-GPVI antibodies in mice.

GrĂ¼ner S, Prostredna M, Koch M, Miura Y, Schulte V, Jung SM, Moroi M, Nieswandt B.

Blood. 2005 Feb 15;105(4):1492-9. Epub 2004 Oct 26.


The platelet receptor GPVI mediates both adhesion and signaling responses to collagen in a receptor density-dependent fashion.

Chen H, Locke D, Liu Y, Liu C, Kahn ML.

J Biol Chem. 2002 Jan 25;277(4):3011-9. Epub 2001 Nov 26.


Human platelet glycoprotein VI function is antagonized by monoclonal antibody-derived Fab fragments.

Lecut C, Feeney LA, Kingsbury G, Hopkins J, Lanza F, Gachet C, Villeval JL, Jandrot-Perrus M.

J Thromb Haemost. 2003 Dec;1(12):2653-62.


Distinct contributions of glycoprotein VI and alpha(2)beta(1) integrin to the induction of platelet protein tyrosine phosphorylation and aggregation.

Kamiguti AS, Theakston RD, Watson SP, Bon C, Laing GD, Zuzel M.

Arch Biochem Biophys. 2000 Feb 15;374(2):356-62.


Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRgamma chain.

Nieswandt B, Bergmeier W, Schulte V, Rackebrandt K, Gessner JE, Zirngibl H.

J Biol Chem. 2000 Aug 4;275(31):23998-4002.


Murine GPVI stimulates weak integrin activation in PLCgamma2-/- platelets: involvement of PLCgamma1 and PI3-kinase.

Suzuki-Inoue K, Inoue O, Frampton J, Watson SP.

Blood. 2003 Aug 15;102(4):1367-73. Epub 2003 May 1.


Globular adiponectin induces platelet activation through the collagen receptor GPVI-Fc receptor gamma chain complex.

Riba R, Hughes CE, Graham A, Watson SP, Naseem KM.

J Thromb Haemost. 2008 Jun;6(6):1012-20. doi: 10.1111/j.1538-7836.2008.02982.x. Epub 2008 Apr 16.


Highly potent anti-human GPVI monoclonal antibodies derived from GPVI knockout mouse immunization.

Matsumoto Y, Takizawa H, Gong X, Le S, Lockyer S, Okuyama K, Tanaka M, Yoshitake M, Tandon NN, Kambayashi J.

Thromb Res. 2007;119(3):319-29. Epub 2006 Mar 6.


Evidence for cross-talk between glycoprotein VI and Gi-coupled receptors during collagen-induced platelet aggregation.

Nieswandt B, Bergmeier W, Eckly A, Schulte V, Ohlmann P, Cazenave JP, Zirngibl H, Offermanns S, Gachet C.

Blood. 2001 Jun 15;97(12):3829-35.


Platelet glycoprotein VI dimerization, an active process inducing receptor competence, is an indicator of platelet reactivity.

Loyau S, Dumont B, Ollivier V, Boulaftali Y, Feldman L, Ajzenberg N, Jandrot-Perrus M.

Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):778-85. doi: 10.1161/ATVBAHA.111.241067. Epub 2011 Dec 8.


Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily.

Jandrot-Perrus M, Busfield S, Lagrue AH, Xiong X, Debili N, Chickering T, Le Couedic JP, Goodearl A, Dussault B, Fraser C, Vainchenker W, Villeval JL.

Blood. 2000 Sep 1;96(5):1798-807.


Non-genomic effects of PPARgamma ligands: inhibition of GPVI-stimulated platelet activation.

Moraes LA, Spyridon M, Kaiser WJ, Jones CI, Sage T, Atherton RE, Gibbins JM.

J Thromb Haemost. 2010 Mar;8(3):577-87. doi: 10.1111/j.1538-7836.2009.03732.x. Epub 2009 Dec 21.


Identification of P2Y12-dependent and -independent mechanisms of glycoprotein VI-mediated Rap1 activation in platelets.

Larson MK, Chen H, Kahn ML, Taylor AM, Fabre JE, Mortensen RM, Conley PB, Parise LV.

Blood. 2003 Feb 15;101(4):1409-15. Epub 2002 Oct 17.

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