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Items: 1 to 20 of 148

1.

Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization.

Verma R, Kovari I, Soofi A, Nihalani D, Patrie K, Holzman LB.

J Clin Invest. 2006 May;116(5):1346-59. Epub 2006 Mar 16.

2.

Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes.

Jones N, Blasutig IM, Eremina V, Ruston JM, Bladt F, Li H, Huang H, Larose L, Li SS, Takano T, Quaggin SE, Pawson T.

Nature. 2006 Apr 6;440(7085):818-23. Epub 2006 Mar 8.

PMID:
16525419
3.

Phosphorylated YDXV motifs and Nck SH2/SH3 adaptors act cooperatively to induce actin reorganization.

Blasutig IM, New LA, Thanabalasuriar A, Dayarathna TK, Goudreault M, Quaggin SE, Li SS, Gruenheid S, Jones N, Pawson T.

Mol Cell Biol. 2008 Mar;28(6):2035-46. doi: 10.1128/MCB.01770-07. Epub 2008 Jan 22.

4.

Rat nephrin modulates cell morphology via the adaptor protein Nck.

Li H, Zhu J, Aoudjit L, Latreille M, Kawachi H, Larose L, Takano T.

Biochem Biophys Res Commun. 2006 Oct 13;349(1):310-6. Epub 2006 Aug 17.

PMID:
16934223
5.

Nck proteins maintain the adult glomerular filtration barrier.

Jones N, New LA, Fortino MA, Eremina V, Ruston J, Blasutig IM, Aoudjit L, Zou Y, Liu X, Yu GL, Takano T, Quaggin SE, Pawson T.

J Am Soc Nephrol. 2009 Jul;20(7):1533-43. doi: 10.1681/ASN.2009010056. Epub 2009 May 14.

6.

Direct regulation of nephrin tyrosine phosphorylation by Nck adaptor proteins.

New LA, Keyvani Chahi A, Jones N.

J Biol Chem. 2013 Jan 18;288(3):1500-10. doi: 10.1074/jbc.M112.439463. Epub 2012 Nov 27.

7.

Dynamics at the slit diaphragm--is nephrin actin'?

Moeller MJ.

Nephrol Dial Transplant. 2007 Jan;22(1):37-9. Epub 2006 Sep 2. No abstract available.

8.

Nck links nephrin to actin in kidney podocytes.

Tryggvason K, Pikkarainen T, Patrakka J.

Cell. 2006 Apr 21;125(2):221-4.

9.

Fyn binds to and phosphorylates the kidney slit diaphragm component Nephrin.

Verma R, Wharram B, Kovari I, Kunkel R, Nihalani D, Wary KK, Wiggins RC, Killen P, Holzman LB.

J Biol Chem. 2003 Jun 6;278(23):20716-23. Epub 2003 Mar 31. Erratum in: J Biol Chem. 2005 Jul 15;280(28):26640.

10.

Phosphorylation of Nephrin Triggers Ca2+ Signaling by Recruitment and Activation of Phospholipase C-{gamma}1.

Harita Y, Kurihara H, Kosako H, Tezuka T, Sekine T, Igarashi T, Ohsawa I, Ohta S, Hattori S.

J Biol Chem. 2009 Mar 27;284(13):8951-62. doi: 10.1074/jbc.M806851200. Epub 2009 Jan 29.

11.

Inducible clustering of membrane-targeted SH3 domains of the adaptor protein Nck triggers localized actin polymerization.

Rivera GM, Briceño CA, Takeshima F, Snapper SB, Mayer BJ.

Curr Biol. 2004 Jan 6;14(1):11-22.

12.

Vascular endothelial growth factor receptor 2 direct interaction with nephrin links VEGF-A signals to actin in kidney podocytes.

Bertuccio C, Veron D, Aggarwal PK, Holzman L, Tufro A.

J Biol Chem. 2011 Nov 18;286(46):39933-44. doi: 10.1074/jbc.M111.241620. Epub 2011 Sep 21.

13.

Nephrin regulates lamellipodia formation by assembling a protein complex that includes Ship2, filamin and lamellipodin.

Venkatareddy M, Cook L, Abuarquob K, Verma R, Garg P.

PLoS One. 2011;6(12):e28710. doi: 10.1371/journal.pone.0028710. Epub 2011 Dec 14.

14.

SRC-family kinase Fyn phosphorylates the cytoplasmic domain of nephrin and modulates its interaction with podocin.

Li H, Lemay S, Aoudjit L, Kawachi H, Takano T.

J Am Soc Nephrol. 2004 Dec;15(12):3006-15.

15.

Nephrotic plasma alters slit diaphragm-dependent signaling and translocates nephrin, Podocin, and CD2 associated protein in cultured human podocytes.

Coward RJ, Foster RR, Patton D, Ni L, Lennon R, Bates DO, Harper SJ, Mathieson PW, Saleem MA.

J Am Soc Nephrol. 2005 Mar;16(3):629-37. Epub 2005 Jan 19.

16.

Nephrin and Neph1 co-localize at the podocyte foot process intercellular junction and form cis hetero-oligomers.

Barletta GM, Kovari IA, Verma RK, Kerjaschki D, Holzman LB.

J Biol Chem. 2003 May 23;278(21):19266-71. Epub 2003 Mar 19.

17.

Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization.

Garg P, Verma R, Nihalani D, Johnstone DB, Holzman LB.

Mol Cell Biol. 2007 Dec;27(24):8698-712. Epub 2007 Oct 8.

18.

Expression of galectin-1, a new component of slit diaphragm, is altered in minimal change nephrotic syndrome.

Shimizu M, Khoshnoodi J, Akimoto Y, Kawakami H, Hirano H, Higashihara E, Hosoyamada M, Sekine Y, Kurayama R, Kurayama H, Joh K, Hirabayashi J, Kasai K, Tryggvason K, Ito N, Yan K.

Lab Invest. 2009 Feb;89(2):178-95. doi: 10.1038/labinvest.2008.125. Epub 2008 Dec 15.

19.

Planar cell polarity pathway regulates actin rearrangement, cell shape, motility, and nephrin distribution in podocytes.

Babayeva S, Zilber Y, Torban E.

Am J Physiol Renal Physiol. 2011 Feb;300(2):F549-60. doi: 10.1152/ajprenal.00566.2009. Epub 2010 Jun 9.

20.

mTOR regulates expression of slit diaphragm proteins and cytoskeleton structure in podocytes.

Vollenbröker B, George B, Wolfgart M, Saleem MA, Pavenstädt H, Weide T.

Am J Physiol Renal Physiol. 2009 Feb;296(2):F418-26. doi: 10.1152/ajprenal.90319.2008. Epub 2008 Nov 19.

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