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Items: 1 to 20 of 436


Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3'-5')-cyclic-GMP in virulence.

Kulasakara H, Lee V, Brencic A, Liberati N, Urbach J, Miyata S, Lee DG, Neely AN, Hyodo M, Hayakawa Y, Ausubel FM, Lory S.

Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2839-44. Epub 2006 Feb 13.


c-di-GMP turn-over in Clostridium difficile is controlled by a plethora of diguanylate cyclases and phosphodiesterases.

Bordeleau E, Fortier LC, Malouin F, Burrus V.

PLoS Genet. 2011 Mar;7(3):e1002039. doi: 10.1371/journal.pgen.1002039. Epub 2011 Mar 31.


Oligoribonuclease is the primary degradative enzyme for pGpG in Pseudomonas aeruginosa that is required for cyclic-di-GMP turnover.

Orr MW, Donaldson GP, Severin GB, Wang J, Sintim HO, Waters CM, Lee VT.

Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):E5048-57. doi: 10.1073/pnas.1507245112. Epub 2015 Aug 24.


Conservative change to the phosphate moiety of cyclic diguanylic monophosphate remarkably affects its polymorphism and ability to bind DGC, PDE, and PilZ proteins.

Wang J, Zhou J, Donaldson GP, Nakayama S, Yan L, Lam YF, Lee VT, Sintim HO.

J Am Chem Soc. 2011 Jun 22;133(24):9320-30. doi: 10.1021/ja1112029. Epub 2011 May 25.


Oligoribonuclease is a central feature of cyclic diguanylate signaling in Pseudomonas aeruginosa.

Cohen D, Mechold U, Nevenzal H, Yarmiyhu Y, Randall TE, Bay DC, Rich JD, Parsek MR, Kaever V, Harrison JJ, Banin E.

Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11359-64. doi: 10.1073/pnas.1421450112. Epub 2015 Aug 24.


Analysis of FimX, a phosphodiesterase that governs twitching motility in Pseudomonas aeruginosa.

Kazmierczak BI, Lebron MB, Murray TS.

Mol Microbiol. 2006 May;60(4):1026-43.


ChIP-Seq and RNA-Seq reveal an AmrZ-mediated mechanism for cyclic di-GMP synthesis and biofilm development by Pseudomonas aeruginosa.

Jones CJ, Newsom D, Kelly B, Irie Y, Jennings LK, Xu B, Limoli DH, Harrison JJ, Parsek MR, White P, Wozniak DJ.

PLoS Pathog. 2014 Mar 6;10(3):e1003984. doi: 10.1371/journal.ppat.1003984. eCollection 2014 Mar.


Specific control of Pseudomonas aeruginosa surface-associated behaviors by two c-di-GMP diguanylate cyclases.

Merritt JH, Ha DG, Cowles KN, Lu W, Morales DK, Rabinowitz J, Gitai Z, O'Toole GA.

MBio. 2010 Oct 19;1(4). pii: e00183-10. doi: 10.1128/mBio.00183-10.


Differential control of Yersinia pestis biofilm formation in vitro and in the flea vector by two c-di-GMP diguanylate cyclases.

Sun YC, Koumoutsi A, Jarrett C, Lawrence K, Gherardini FC, Darby C, Hinnebusch BJ.

PLoS One. 2011 Apr 29;6(4):e19267. doi: 10.1371/journal.pone.0019267.


The diguanylate cyclase GcbA facilitates Pseudomonas aeruginosa biofilm dispersion by activating BdlA.

Petrova OE, Cherny KE, Sauer K.

J Bacteriol. 2015 Jan 1;197(1):174-87. doi: 10.1128/JB.02244-14. Epub 2014 Oct 20.


Nitric oxide regulation of cyclic di-GMP synthesis and hydrolysis in Shewanella woodyi.

Liu N, Xu Y, Hossain S, Huang N, Coursolle D, Gralnick JA, Boon EM.

Biochemistry. 2012 Mar 13;51(10):2087-99. doi: 10.1021/bi201753f. Epub 2012 Mar 5.


Multiple diguanylate cyclase-coordinated regulation of pyoverdine synthesis in Pseudomonas aeruginosa.

Chen Y, Yuan M, Mohanty A, Yam JK, Liu Y, Chua SL, Nielsen TE, Tolker-Nielsen T, Givskov M, Cao B, Yang L.

Environ Microbiol Rep. 2015 Jun;7(3):498-507. doi: 10.1111/1758-2229.12278. Epub 2015 Apr 8.


Systematic analysis of diguanylate cyclases that promote biofilm formation by Pseudomonas fluorescens Pf0-1.

Newell PD, Yoshioka S, Hvorecny KL, Monds RD, O'Toole GA.

J Bacteriol. 2011 Sep;193(18):4685-98. doi: 10.1128/JB.05483-11. Epub 2011 Jul 15.


The second messenger bis-(3'-5')-cyclic-GMP and its PilZ domain-containing receptor Alg44 are required for alginate biosynthesis in Pseudomonas aeruginosa.

Merighi M, Lee VT, Hyodo M, Hayakawa Y, Lory S.

Mol Microbiol. 2007 Aug;65(4):876-95. Epub 2007 Jul 21.


[Activity of cyclic diguanylate (c-di-GMP) in bacteria and the study of its derivatives].

Na LX, Yang ZJ.

Yao Xue Xue Bao. 2012 Mar;47(3):307-12. Review. Chinese.


Cyclic Di-GMP modulates the disease progression of Erwinia amylovora.

Edmunds AC, Castiblanco LF, Sundin GW, Waters CM.

J Bacteriol. 2013 May;195(10):2155-65. doi: 10.1128/JB.02068-12. Epub 2013 Mar 8. Erratum in: J Bacteriol. 2013 Oct;195(20):4778.


Multiple activities of c-di-GMP in Pseudomonas aeruginosa.

Lory S, Merighi M, Hyodo M.

Nucleic Acids Symp Ser (Oxf). 2009;(53):51-2. doi: 10.1093/nass/nrp026.


Identification and characterization of cyclic diguanylate signaling systems controlling rugosity in Vibrio cholerae.

Beyhan S, Odell LS, Yildiz FH.

J Bacteriol. 2008 Nov;190(22):7392-405. doi: 10.1128/JB.00564-08. Epub 2008 Sep 12.

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