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Results: 1 to 20 of 192

1.

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks.

Stucki M, Clapperton JA, Mohammad D, Yaffe MB, Smerdon SJ, Jackson SP.

Cell. 2005 Dec 29;123(7):1213-26. Erratum in: Cell. 2008 May 2;133(3):549.

PMID:
16377563
[PubMed - indexed for MEDLINE]
Free Article
2.

Structure of the BRCT repeat domain of MDC1 and its specificity for the free COOH-terminal end of the gamma-H2AX histone tail.

Lee MS, Edwards RA, Thede GL, Glover JN.

J Biol Chem. 2005 Sep 16;280(37):32053-6. Epub 2005 Jul 27.

PMID:
16049003
[PubMed - indexed for MEDLINE]
Free Article
3.

MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotes.

Stucki M, Jackson SP.

DNA Repair (Amst). 2004 Aug-Sep;3(8-9):953-7. Review.

PMID:
15279781
[PubMed - indexed for MEDLINE]
4.

NFBD1, a novel nuclear protein with signature motifs of FHA and BRCT, and an internal 41-amino acid repeat sequence, is an early participant in DNA damage response.

Shang YL, Bodero AJ, Chen PL.

J Biol Chem. 2003 Feb 21;278(8):6323-9. Epub 2002 Dec 9.

PMID:
12475977
[PubMed - indexed for MEDLINE]
Free Article
5.

The DNA damage response mediator MDC1 directly interacts with the anaphase-promoting complex/cyclosome.

Coster G, Hayouka Z, Argaman L, Strauss C, Friedler A, Brandeis M, Goldberg M.

J Biol Chem. 2007 Nov 2;282(44):32053-64. Epub 2007 Sep 7.

PMID:
17827148
[PubMed - indexed for MEDLINE]
Free Article
6.

gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes.

Stucki M, Jackson SP.

DNA Repair (Amst). 2006 May 10;5(5):534-43. Epub 2006 Mar 10. Review.

PMID:
16531125
[PubMed - indexed for MEDLINE]
7.

MDC1 is a mediator of the mammalian DNA damage checkpoint.

Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ.

Nature. 2003 Feb 27;421(6926):961-6.

PMID:
12607005
[PubMed - indexed for MEDLINE]
8.

NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damage.

Peng A, Chen PL.

J Biol Chem. 2003 Mar 14;278(11):8873-6. Epub 2003 Jan 24.

PMID:
12551934
[PubMed - indexed for MEDLINE]
Free Article
9.

Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.

Furuta T, Takemura H, Liao ZY, Aune GJ, Redon C, Sedelnikova OA, Pilch DR, Rogakou EP, Celeste A, Chen HT, Nussenzweig A, Aladjem MI, Bonner WM, Pommier Y.

J Biol Chem. 2003 May 30;278(22):20303-12. Epub 2003 Mar 25.

PMID:
12660252
[PubMed - indexed for MEDLINE]
Free Article
10.

The direct interaction between 53BP1 and MDC1 is required for the recruitment of 53BP1 to sites of damage.

Eliezer Y, Argaman L, Rhie A, Doherty AJ, Goldberg M.

J Biol Chem. 2009 Jan 2;284(1):426-35. doi: 10.1074/jbc.M807375200. Epub 2008 Nov 5.

PMID:
18986980
[PubMed - indexed for MEDLINE]
Free Article
11.

Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage.

Chapman JR, Jackson SP.

EMBO Rep. 2008 Aug;9(8):795-801. doi: 10.1038/embor.2008.103. Epub 2008 Jun 27.

PMID:
18583988
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

gammaH2AX foci form preferentially in euchromatin after ionising-radiation.

Cowell IG, Sunter NJ, Singh PB, Austin CA, Durkacz BW, Tilby MJ.

PLoS One. 2007 Oct 24;2(10):e1057.

PMID:
17957241
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways.

Xu X, Stern DF.

J Biol Chem. 2003 Mar 7;278(10):8795-803. Epub 2002 Dec 23.

PMID:
12499369
[PubMed - indexed for MEDLINE]
Free Article
14.

Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention.

Lukas C, Melander F, Stucki M, Falck J, Bekker-Jensen S, Goldberg M, Lerenthal Y, Jackson SP, Bartek J, Lukas J.

EMBO J. 2004 Jul 7;23(13):2674-83. Epub 2004 Jun 17.

PMID:
15201865
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Crosstalk between histone modifications during the DNA damage response.

van Attikum H, Gasser SM.

Trends Cell Biol. 2009 May;19(5):207-17. doi: 10.1016/j.tcb.2009.03.001. Epub 2009 Apr 1. Review.

PMID:
19342239
[PubMed - indexed for MEDLINE]
16.

NFBD1/Mdc1 mediates ATR-dependent DNA damage response.

Peng A, Chen PL.

Cancer Res. 2005 Feb 15;65(4):1158-63.

PMID:
15734998
[PubMed - indexed for MEDLINE]
Free Article
17.

A divalent FHA/BRCT-binding mechanism couples the MRE11-RAD50-NBS1 complex to damaged chromatin.

Hari FJ, Spycher C, Jungmichel S, Pavic L, Stucki M.

EMBO Rep. 2010 May;11(5):387-92. doi: 10.1038/embor.2010.30. Epub 2010 Mar 12.

PMID:
20224574
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors.

Xu X, Stern DF.

FASEB J. 2003 Oct;17(13):1842-8.

PMID:
14519663
[PubMed - indexed for MEDLINE]
Free Article
19.

PP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpoint.

Nakada S, Chen GI, Gingras AC, Durocher D.

EMBO Rep. 2008 Oct;9(10):1019-26. doi: 10.1038/embor.2008.162. Epub 2008 Aug 29. Erratum in: EMBO Rep. 2008 Dec;9(12):1251.

PMID:
18758438
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.

Mailand N, Bekker-Jensen S, Faustrup H, Melander F, Bartek J, Lukas C, Lukas J.

Cell. 2007 Nov 30;131(5):887-900. Epub 2007 Nov 20.

PMID:
18001824
[PubMed - indexed for MEDLINE]
Free Article

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