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Results: 1 to 20 of 822

1.

Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production.

Trifunovic A, Hansson A, Wredenberg A, Rovio AT, Dufour E, Khvorostov I, Spelbrink JN, Wibom R, Jacobs HT, Larsson NG.

Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):17993-8. Epub 2005 Dec 6.

PMID:
16332961
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Respiratory function decline and DNA mutation in mitochondria, oxidative stress and altered gene expression during aging.

Wei YH, Wu SB, Ma YS, Lee HC.

Chang Gung Med J. 2009 Mar-Apr;32(2):113-32. Review.

PMID:
19403001
[PubMed - indexed for MEDLINE]
Free Article
3.

Oxidative damage and mutation to mitochondrial DNA and age-dependent decline of mitochondrial respiratory function.

Wei YH, Lu CY, Lee HC, Pang CY, Ma YS.

Ann N Y Acad Sci. 1998 Nov 20;854:155-70. Review.

PMID:
9928427
[PubMed - indexed for MEDLINE]
4.

Oxidative stress and mitochondrial DNA mutations in human aging.

Wei YH.

Proc Soc Exp Biol Med. 1998 Jan;217(1):53-63. Review.

PMID:
9421207
[PubMed - indexed for MEDLINE]
5.

Oxidative stress in human aging and mitochondrial disease-consequences of defective mitochondrial respiration and impaired antioxidant enzyme system.

Wei YH, Lu CY, Wei CY, Ma YS, Lee HC.

Chin J Physiol. 2001 Mar 31;44(1):1-11. Review.

PMID:
11403514
[PubMed - indexed for MEDLINE]
6.

Mitochondrial dysfunction in mammalian ageing.

Terzioglu M, Larsson NG.

Novartis Found Symp. 2007;287:197-208; discussion 208-13. Review.

PMID:
18074640
[PubMed - indexed for MEDLINE]
7.

Mitochondrial theory of aging matures--roles of mtDNA mutation and oxidative stress in human aging.

Wei YH, Ma YS, Lee HC, Lee CF, Lu CY.

Zhonghua Yi Xue Za Zhi (Taipei). 2001 May;64(5):259-70. Review.

PMID:
11499335
[PubMed - indexed for MEDLINE]
8.

The mtDNA mutator mouse: Dissecting mitochondrial involvement in aging.

Edgar D, Trifunovic A.

Aging (Albany NY). 2009 Dec 11;1(12):1028-32.

PMID:
20157586
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Mitochondrial dysfunction as a cause of ageing.

Trifunovic A, Larsson NG.

J Intern Med. 2008 Feb;263(2):167-78. doi: 10.1111/j.1365-2796.2007.01905.x.

PMID:
18226094
[PubMed - indexed for MEDLINE]
10.

Oxidative stress, mitochondrial DNA mutation, and apoptosis in aging.

Lee HC, Wei YH.

Exp Biol Med (Maywood). 2007 May;232(5):592-606. Review.

PMID:
17463155
[PubMed - indexed for MEDLINE]
11.

Mitochondrial DNA mutations and oxidative damage in aging and diseases: an emerging paradigm of gerontology and medicine.

Wei YH.

Proc Natl Sci Counc Repub China B. 1998 Apr;22(2):55-67. Review.

PMID:
9615468
[PubMed - indexed for MEDLINE]
12.

Oxidative stress, mitochondria and mtDNA-mutator mice.

Thompson LV.

Exp Gerontol. 2006 Dec;41(12):1220-2. Epub 2006 Nov 28. Review.

PMID:
17126516
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Somatic mtDNA mutations and aging--facts and fancies.

Kukat A, Trifunovic A.

Exp Gerontol. 2009 Jan-Feb;44(1-2):101-5. doi: 10.1016/j.exger.2008.05.006. Epub 2008 May 21. Review.

PMID:
18585880
[PubMed - indexed for MEDLINE]
14.

Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice.

Edgar D, Shabalina I, Camara Y, Wredenberg A, Calvaruso MA, Nijtmans L, Nedergaard J, Cannon B, Larsson NG, Trifunovic A.

Cell Metab. 2009 Aug;10(2):131-8. doi: 10.1016/j.cmet.2009.06.010.

PMID:
19656491
[PubMed - indexed for MEDLINE]
Free Article
15.

Oxidative stress, mitochondrial DNA mutation, and impairment of antioxidant enzymes in aging.

Wei YH, Lee HC.

Exp Biol Med (Maywood). 2002 Oct;227(9):671-82. Review.

PMID:
12324649
[PubMed - indexed for MEDLINE]
16.

Animal models for mitochondrial disease.

Wallace DC.

Methods Mol Biol. 2002;197:3-54. Review.

PMID:
12013805
[PubMed - indexed for MEDLINE]
17.

Understanding aging: revealing order out of chaos.

Dufour E, Larsson NG.

Biochim Biophys Acta. 2004 Jul 23;1658(1-2):122-32. Review.

PMID:
15282183
[PubMed - indexed for MEDLINE]
Free Article
18.

A mitochondrial paradigm for degenerative diseases and ageing.

Wallace DC.

Novartis Found Symp. 2001;235:247-63; discussion 263-6. Review.

PMID:
11280029
[PubMed - indexed for MEDLINE]
19.

Mutation and oxidative damage of mitochondrial DNA and defective turnover of mitochondria in human aging.

Lee HC, Wei YH.

J Formos Med Assoc. 1997 Oct;96(10):770-8. Review.

PMID:
9343975
[PubMed - indexed for MEDLINE]
20.

The role of mitochondrial DNA mutations in aging and sarcopenia: implications for the mitochondrial vicious cycle theory of aging.

Hiona A, Leeuwenburgh C.

Exp Gerontol. 2008 Jan;43(1):24-33. Epub 2007 Oct 4. Review.

PMID:
17997255
[PubMed - indexed for MEDLINE]
Free PMC Article

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