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Results: 1 to 20 of 114

1.

Reducing effect of the positive allosteric modulators of the GABA(B) receptor, CGP7930 and GS39783, on alcohol intake in alcohol-preferring rats.

Orrù A, Lai P, Lobina C, Maccioni P, Piras P, Scanu L, Froestl W, Gessa GL, Carai MA, Colombo G.

Eur J Pharmacol. 2005 Nov 21;525(1-3):105-11. Epub 2005 Nov 14.

PMID:
16289452
[PubMed - indexed for MEDLINE]
2.

Comparison of the effect of the GABAΒ receptor agonist, baclofen, and the positive allosteric modulator of the GABAB receptor, GS39783, on alcohol self-administration in 3 different lines of alcohol-preferring rats.

Maccioni P, Zaru A, Loi B, Lobina C, Carai MA, Gessa GL, Capra A, Mugnaini C, Pasquini S, Corelli F, Hyytiä P, Lumeng L, Colombo G.

Alcohol Clin Exp Res. 2012 Oct;36(10):1748-66. doi: 10.1111/j.1530-0277.2012.01782.x. Epub 2012 Apr 6.

PMID:
22486245
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Reduction of alcohol intake by the positive allosteric modulator of the GABA(B) receptor, rac-BHFF, in alcohol-preferring rats.

Loi B, Maccioni P, Lobina C, Carai MA, Gessa GL, Thomas AW, Malherbe P, Colombo G.

Alcohol. 2013 Feb;47(1):69-73. doi: 10.1016/j.alcohol.2012.11.002. Epub 2012 Dec 6.

PMID:
23218664
[PubMed - indexed for MEDLINE]
4.

Reduction of alcohol's reinforcing and motivational properties by the positive allosteric modulator of the GABA(B) receptor, BHF177, in alcohol-preferring rats.

Maccioni P, Carai MA, Kaupmann K, Guery S, Froestl W, Leite-Morris KA, Gessa GL, Colombo G.

Alcohol Clin Exp Res. 2009 Oct;33(10):1749-56. doi: 10.1111/j.1530-0277.2009.01012.x. Epub 2009 Jul 1.

PMID:
19572981
[PubMed - indexed for MEDLINE]
5.

Reducing effect of the positive allosteric modulator of the GABA(B) receptor, GS39,783, on alcohol self-administration in alcohol-preferring rats.

Maccioni P, Pes D, Orrù A, Froestl W, Gessa GL, Carai MA, Colombo G.

Psychopharmacology (Berl). 2007 Aug;193(2):171-8. Epub 2007 Mar 29.

PMID:
17393141
[PubMed - indexed for MEDLINE]
6.

Effects of intraperitoneal administration of the GABAB receptor positive allosteric modulator 2,6-di tert-butyl-4-(2-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) on food intake in non-deprived rats.

Ebenezer IS.

Eur J Pharmacol. 2012 Sep 5;690(1-3):115-8. doi: 10.1016/j.ejphar.2012.05.021. Epub 2012 May 28.

PMID:
22652431
[PubMed - indexed for MEDLINE]
7.

Effects of positive allosteric modulators of the GABAB receptor on cocaine self-administration in rats.

Smith MA, Yancey DL, Morgan D, Liu Y, Froestl W, Roberts DC.

Psychopharmacology (Berl). 2004 Apr;173(1-2):105-11. Epub 2004 Jan 8.

PMID:
14712341
[PubMed - indexed for MEDLINE]
8.

Specific reduction of alcohol's motivational properties by the positive allosteric modulator of the GABAB receptor, GS39783--comparison with the effect of the GABAB receptor direct agonist, baclofen.

Maccioni P, Fantini N, Froestl W, Carai MA, Gessa GL, Colombo G.

Alcohol Clin Exp Res. 2008 Sep;32(9):1558-64. doi: 10.1111/j.1530-0277.2008.00725.x. Epub 2008 Jul 9.

PMID:
18616673
[PubMed - indexed for MEDLINE]
9.

N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and structurally related compounds: novel allosteric enhancers of gamma-aminobutyric acidB receptor function.

Urwyler S, Pozza MF, Lingenhoehl K, Mosbacher J, Lampert C, Froestl W, Koller M, Kaupmann K.

J Pharmacol Exp Ther. 2003 Oct;307(1):322-30. Epub 2003 Sep 3.

PMID:
12954816
[PubMed - indexed for MEDLINE]
Free Article
10.

Positive modulation of GABA(B) receptors decreased nicotine self-administration and counteracted nicotine-induced enhancement of brain reward function in rats.

Paterson NE, Vlachou S, Guery S, Kaupmann K, Froestl W, Markou A.

J Pharmacol Exp Ther. 2008 Jul;326(1):306-14. doi: 10.1124/jpet.108.139204. Epub 2008 Apr 29.

PMID:
18445779
[PubMed - indexed for MEDLINE]
Free PMC Article
11.
12.

Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501.

Urwyler S, Mosbacher J, Lingenhoehl K, Heid J, Hofstetter K, Froestl W, Bettler B, Kaupmann K.

Mol Pharmacol. 2001 Nov;60(5):963-71.

PMID:
11641424
[PubMed - indexed for MEDLINE]
Free Article
13.

Mechanisms of allosteric modulation at GABAB receptors by CGP7930 and GS39783: effects on affinities and efficacies of orthosteric ligands with distinct intrinsic properties.

Urwyler S, Gjoni T, Koljatić J, Dupuis DS.

Neuropharmacology. 2005 Mar;48(3):343-53. Epub 2005 Jan 25.

PMID:
15721166
[PubMed - indexed for MEDLINE]
14.

The GABA(B) receptor allosteric modulator CGP7930, like baclofen, reduces operant self-administration of ethanol in alcohol-preferring rats.

Liang JH, Chen F, Krstew E, Cowen MS, Carroll FY, Crawford D, Beart PM, Lawrence AJ.

Neuropharmacology. 2006 Apr;50(5):632-9. Epub 2006 Jan 9. Erratum in: Neuropharmacology. 2006 Sep;51(3):692.

PMID:
16406445
[PubMed - indexed for MEDLINE]
15.

Role of the GABA(B) receptor in alcohol-seeking and drinking behavior.

Maccioni P, Colombo G.

Alcohol. 2009 Nov;43(7):555-8. doi: 10.1016/j.alcohol.2009.09.030. Review.

PMID:
19913200
[PubMed - indexed for MEDLINE]
16.

Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepines.

Cryan JF, Kelly PH, Chaperon F, Gentsch C, Mombereau C, Lingenhoehl K, Froestl W, Bettler B, Kaupmann K, Spooren WP.

J Pharmacol Exp Ther. 2004 Sep;310(3):952-63. Epub 2004 Apr 27.

PMID:
15113848
[PubMed - indexed for MEDLINE]
Free Article
17.

GABA(B) receptor-positive modulation decreases selective molecular and behavioral effects of cocaine.

Lhuillier L, Mombereau C, Cryan JF, Kaupmann K.

Neuropsychopharmacology. 2007 Feb;32(2):388-98. Epub 2006 May 17.

PMID:
16710312
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Role of GABA(B) receptor in alcohol dependence: reducing effect of baclofen on alcohol intake and alcohol motivational properties in rats and amelioration of alcohol withdrawal syndrome and alcohol craving in human alcoholics.

Colombo G, Addolorato G, Agabio R, Carai MA, Pibiri F, Serra S, Vacca G, Gessa GL.

Neurotox Res. 2004;6(5):403-14. Review.

PMID:
15545024
[PubMed - indexed for MEDLINE]
19.

The GABA(B) receptor agonists baclofen and CGP 44532 prevent acquisition of alcohol drinking behaviour in alcohol-preferring rats.

Colombo G, Serra S, Brunetti G, Atzori G, Pani M, Vacca G, Addolorato G, Froestl W, Carai MA, Gessa GL.

Alcohol Alcohol. 2002 Sep-Oct;37(5):499-503.

PMID:
12217946
[PubMed - indexed for MEDLINE]
Free Article
20.

The positive allosteric modulator of the GABA(B) receptor, rac-BHFF, suppresses alcohol self-administration.

Maccioni P, Thomas AW, Carai MA, Gessa GL, Malherbe P, Colombo G.

Drug Alcohol Depend. 2010 Jun 1;109(1-3):96-103. doi: 10.1016/j.drugalcdep.2009.12.019. Epub 2010 Jan 20.

PMID:
20089372
[PubMed - indexed for MEDLINE]

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