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Results: 1 to 20 of 121

1.

Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2.

Tavazoie SF, Alvarez VA, Ridenour DA, Kwiatkowski DJ, Sabatini BL.

Nat Neurosci. 2005 Dec;8(12):1727-34. Epub 2005 Nov 6.

PMID:
16286931
[PubMed - indexed for MEDLINE]
2.

Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner.

Di Nardo A, Kramvis I, Cho N, Sadowski A, Meikle L, Kwiatkowski DJ, Sahin M.

J Neurosci. 2009 May 6;29(18):5926-37. doi: 10.1523/JNEUROSCI.0778-09.2009.

PMID:
19420259
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Heterozygosity for the tuberous sclerosis complex (TSC) gene products results in increased astrocyte numbers and decreased p27-Kip1 expression in TSC2+/- cells.

Uhlmann EJ, Apicelli AJ, Baldwin RL, Burke SP, Bajenaru ML, Onda H, Kwiatkowski D, Gutmann DH.

Oncogene. 2002 Jun 6;21(25):4050-9.

PMID:
12037687
[PubMed - indexed for MEDLINE]
Free Article
4.

Antisense suppression of TSC1 gene product, hamartin, enhances neurite outgrowth in NGF-treated PC12h cells.

Floricel F, Higaki K, Maki H, Nanba E, Ninomiya H, Ohno K.

Brain Dev. 2007 Sep;29(8):502-9. Epub 2007 Mar 21.

PMID:
17376623
[PubMed - indexed for MEDLINE]
5.

A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival.

Meikle L, Talos DM, Onda H, Pollizzi K, Rotenberg A, Sahin M, Jensen FE, Kwiatkowski DJ.

J Neurosci. 2007 May 23;27(21):5546-58.

PMID:
17522300
[PubMed - indexed for MEDLINE]
Free Article
6.

A role for RhoB in synaptic plasticity and the regulation of neuronal morphology.

McNair K, Spike R, Guilding C, Prendergast GC, Stone TW, Cobb SR, Morris BJ.

J Neurosci. 2010 Mar 3;30(9):3508-17. doi: 10.1523/JNEUROSCI.5386-09.2010.

PMID:
20203211
[PubMed - indexed for MEDLINE]
Free Article
7.

Analysis of 65 tuberous sclerosis complex (TSC) patients by TSC2 DGGE, TSC1/TSC2 MLPA, and TSC1 long-range PCR sequencing, and report of 28 novel mutations.

Rendtorff ND, Bjerregaard B, Frödin M, Kjaergaard S, Hove H, Skovby F, Brøndum-Nielsen K, Schwartz M; Danish Tuberous Sclerosis Group.

Hum Mutat. 2005 Oct;26(4):374-83.

PMID:
16114042
[PubMed - indexed for MEDLINE]
8.

Enhanced episodic-like memory and kindling epilepsy in a rat model of tuberous sclerosis.

Waltereit R, Welzl H, Dichgans J, Lipp HP, Schmidt WJ, Weller M.

J Neurochem. 2006 Jan;96(2):407-13. Epub 2005 Nov 21.

PMID:
16300636
[PubMed - indexed for MEDLINE]
9.

Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of tuberous sclerosis complex.

Zeng LH, Rensing NR, Zhang B, Gutmann DH, Gambello MJ, Wong M.

Hum Mol Genet. 2011 Feb 1;20(3):445-54. doi: 10.1093/hmg/ddq491. Epub 2010 Nov 9.

PMID:
21062901
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Tuberous sclerosis complex: linking growth and energy signaling pathways with human disease.

Astrinidis A, Henske EP.

Oncogene. 2005 Nov 14;24(50):7475-81. Review.

PMID:
16288294
[PubMed - indexed for MEDLINE]
11.

Developmental origin of subependymal giant cell astrocytoma in tuberous sclerosis complex.

Ess KC, Kamp CA, Tu BP, Gutmann DH.

Neurology. 2005 Apr 26;64(8):1446-9.

PMID:
15851742
[PubMed - indexed for MEDLINE]
12.

Generation of a conditional disruption of the Tsc2 gene.

Hernandez O, Way S, McKenna J 3rd, Gambello MJ.

Genesis. 2007 Feb;45(2):101-6.

PMID:
17245776
[PubMed - indexed for MEDLINE]
13.

Tsc2 null murine neuroepithelial cells are a model for human tuber giant cells, and show activation of an mTOR pathway.

Onda H, Crino PB, Zhang H, Murphey RD, Rastelli L, Gould Rothberg BE, Kwiatkowski DJ.

Mol Cell Neurosci. 2002 Dec;21(4):561-74.

PMID:
12504590
[PubMed - indexed for MEDLINE]
14.

Expression profiling in tuberous sclerosis complex (TSC) knockout mouse astrocytes to characterize human TSC brain pathology.

Ess KC, Uhlmann EJ, Li W, Li H, Declue JE, Crino PB, Gutmann DH.

Glia. 2004 Apr 1;46(1):28-40.

PMID:
14999811
[PubMed - indexed for MEDLINE]
15.

The tuberous sclerosis genes, TSC1 and TSC2, trigger different gene expression responses.

Rosner M, Freilinger A, Lubec G, Hengstschläger M.

Int J Oncol. 2005 Nov;27(5):1411-24.

PMID:
16211238
[PubMed - indexed for MEDLINE]
16.

Efficacy of a rapamycin analog (CCI-779) and IFN-gamma in tuberous sclerosis mouse models.

Lee L, Sudentas P, Donohue B, Asrican K, Worku A, Walker V, Sun Y, Schmidt K, Albert MS, El-Hashemite N, Lader AS, Onda H, Zhang H, Kwiatkowski DJ, Dabora SL.

Genes Chromosomes Cancer. 2005 Mar;42(3):213-27.

PMID:
15578690
[PubMed - indexed for MEDLINE]
17.

The neurobiology of the tuberous sclerosis complex.

Marcotte L, Crino PB.

Neuromolecular Med. 2006;8(4):531-46. Review.

PMID:
17028374
[PubMed - indexed for MEDLINE]
18.

Rapamycin weekly maintenance dosing and the potential efficacy of combination sorafenib plus rapamycin but not atorvastatin or doxycycline in tuberous sclerosis preclinical models.

Lee N, Woodrum CL, Nobil AM, Rauktys AE, Messina MP, Dabora SL.

BMC Pharmacol. 2009 Apr 15;9:8. doi: 10.1186/1471-2210-9-8.

PMID:
19368729
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Mutational analysis of TSC1 and TSC2 in Korean patients with tuberous sclerosis complex.

Choi JE, Chae JH, Hwang YS, Kim KJ.

Brain Dev. 2006 Aug;28(7):440-6. Epub 2006 Mar 22.

PMID:
16554133
[PubMed - indexed for MEDLINE]
20.

Functional characterisation of the TSC1-TSC2 complex to assess multiple TSC2 variants identified in single families affected by tuberous sclerosis complex.

Nellist M, Sancak O, Goedbloed M, Adriaans A, Wessels M, Maat-Kievit A, Baars M, Dommering C, van den Ouweland A, Halley D.

BMC Med Genet. 2008 Feb 26;9:10. doi: 10.1186/1471-2350-9-10.

PMID:
18302728
[PubMed - indexed for MEDLINE]
Free PMC Article

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