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p21-activated kinase links Rac/Cdc42 signaling to merlin.

Xiao GH, Beeser A, Chernoff J, Testa JR.

J Biol Chem. 2002 Jan 11;277(2):883-6. Epub 2001 Nov 21.


Inactivation of the NF2 tumor suppressor protein merlin in DU145 prostate cancer cells.

Horiguchi A, Zheng R, Shen R, Nanus DM.

Prostate. 2008 Jun 15;68(9):975-84. doi: 10.1002/pros.20760.


Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK.

del Pozo MA, Price LS, Alderson NB, Ren XD, Schwartz MA.

EMBO J. 2000 May 2;19(9):2008-14.


Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1.

Kissil JL, Wilker EW, Johnson KC, Eckman MS, Yaffe MB, Jacks T.

Mol Cell. 2003 Oct;12(4):841-9.


Shedding light on Merlin's wizardry.

Okada T, You L, Giancotti FG.

Trends Cell Biol. 2007 May;17(5):222-9. Epub 2007 Apr 17. Review. Erratum in: Trends Cell Biol. 2008 Jan;18(1):11.


The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.

Shaw RJ, Paez JG, Curto M, Yaktine A, Pruitt WM, Saotome I, O'Bryan JP, Gupta V, Ratner N, Der CJ, Jacks T, McClatchey AI.

Dev Cell. 2001 Jul;1(1):63-72.


Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization.

Kissil JL, Johnson KC, Eckman MS, Jacks T.

J Biol Chem. 2002 Mar 22;277(12):10394-9. Epub 2002 Jan 8.


Upregulation of the Rac1/JNK signaling pathway in primary human schwannoma cells.

Kaempchen K, Mielke K, Utermark T, Langmesser S, Hanemann CO.

Hum Mol Genet. 2003 Jun 1;12(11):1211-21.


Merlin/neurofibromatosis type 2 suppresses growth by inhibiting the activation of Ras and Rac.

Morrison H, Sperka T, Manent J, Giovannini M, Ponta H, Herrlich P.

Cancer Res. 2007 Jan 15;67(2):520-7.


Cyclic AMP-dependent protein kinase phosphorylates merlin at serine 518 independently of p21-activated kinase and promotes merlin-ezrin heterodimerization.

Alfthan K, Heiska L, Grönholm M, Renkema GH, Carpén O.

J Biol Chem. 2004 Apr 30;279(18):18559-66. Epub 2004 Feb 23.


Paxillin phosphorylation at Ser273 localizes a GIT1-PIX-PAK complex and regulates adhesion and protrusion dynamics.

Nayal A, Webb DJ, Brown CM, Schaefer EM, Vicente-Manzanares M, Horwitz AR.

J Cell Biol. 2006 May 22;173(4):587-9.


The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression.

Xiao GH, Gallagher R, Shetler J, Skele K, Altomare DA, Pestell RG, Jhanwar S, Testa JR.

Mol Cell Biol. 2005 Mar;25(6):2384-94.


Adhesion signaling: PAK meets Rac on solid ground.

Symons M.

Curr Biol. 2000 Jul 13;10(14):R535-7. Review.


Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila.

Hing H, Xiao J, Harden N, Lim L, Zipursky SL.

Cell. 1999 Jun 25;97(7):853-63.


Contact-dependent inhibition of EGFR signaling by Nf2/Merlin.

Curto M, Cole BK, Lallemand D, Liu CH, McClatchey AI.

J Cell Biol. 2007 Jun 4;177(5):893-903.


PAK kinase regulates Rac GTPase and is a potential target in human schwannomas.

Flaiz C, Chernoff J, Ammoun S, Peterson JR, Hanemann CO.

Exp Neurol. 2009 Jul;218(1):137-44. doi: 10.1016/j.expneurol.2009.04.019. Epub 2009 May 3.

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