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Results: 1 to 20 of 167

1.

A safety assessment of coumarin taking into account species-specificity of toxicokinetics.

Felter SP, Vassallo JD, Carlton BD, Daston GP.

Food Chem Toxicol. 2006 Apr;44(4):462-75. Epub 2005 Oct 3. Review.

PMID:
16203076
[PubMed - indexed for MEDLINE]
2.

Coumarin metabolism, toxicity and carcinogenicity: relevance for human risk assessment.

Lake BG.

Food Chem Toxicol. 1999 Apr;37(4):423-53. Review.

PMID:
10418958
[PubMed - indexed for MEDLINE]
3.

Species-specific differences in coumarin-induced hepatotoxicity as an example toxicogenomics-based approach to assessing risk of toxicity to humans.

Uehara T, Kiyosawa N, Shimizu T, Omura K, Hirode M, Imazawa T, Mizukawa Y, Ono A, Miyagishima T, Nagao T, Urushidani T.

Hum Exp Toxicol. 2008 Jan;27(1):23-35. doi: 10.1177/0960327107087910.

PMID:
18480146
[PubMed - indexed for MEDLINE]
4.

Safety and nutritional assessment of GM plants and derived food and feed: the role of animal feeding trials.

EFSA GMO Panel Working Group on Animal Feeding Trials.

Food Chem Toxicol. 2008 Mar;46 Suppl 1:S2-70. doi: 10.1016/j.fct.2008.02.008. Epub 2008 Feb 13. Review.

PMID:
18328408
[PubMed - indexed for MEDLINE]
5.

Roles for epoxidation and detoxification of coumarin in determining species differences in clara cell toxicity.

Vassallo JD, Hicks SM, Born SL, Daston GP.

Toxicol Sci. 2004 Nov;82(1):26-33. Epub 2004 Jul 28. Erratum in: Toxicol Sci. 2004 Dec;82(2):following table of contents.

PMID:
15282406
[PubMed - indexed for MEDLINE]
Free Article
6.

A toxicogenomics-based parallelogram approach to evaluate the relevance of coumarin-induced responses in primary human hepatocytes in vitro for humans in vivo.

Kienhuis AS, van de Poll MC, Dejong CH, Gottschalk R, van Herwijnen M, Boorsma A, Kleinjans JC, Stierum RH, van Delft JH.

Toxicol In Vitro. 2009 Sep;23(6):1163-9. doi: 10.1016/j.tiv.2009.06.005. Epub 2009 Jun 13.

PMID:
19527782
[PubMed - indexed for MEDLINE]
7.

Intraperitoneal administration of coumarin causes tissue-selective depletion of cytochromes P450 and cytotoxicity in the olfactory mucosa.

Gu J, Walker VE, Lipinskas TW, Walker DM, Ding X.

Toxicol Appl Pharmacol. 1997 Sep;146(1):134-43.

PMID:
9299605
[PubMed - indexed for MEDLINE]
10.

Studies on the disposition, metabolism and hepatotoxicity of coumarin in the rat and Syrian hamster.

Lake BG, Evans JG, Chapuis F, Walters DG, Price RJ.

Food Chem Toxicol. 2002 Jun;40(6):809-23.

PMID:
11983276
[PubMed - indexed for MEDLINE]
11.

Ethyl methanesulfonate toxicity in Viracept--a comprehensive human risk assessment based on threshold data for genotoxicity.

Müller L, Gocke E, Lavé T, Pfister T.

Toxicol Lett. 2009 Nov 12;190(3):317-29. doi: 10.1016/j.toxlet.2009.04.003. Epub 2009 Apr 10.

PMID:
19443141
[PubMed - indexed for MEDLINE]
12.

Mouse specific lung tumors from CYP2F2-mediated cytotoxic metabolism: an endpoint/toxic response where data from multiple chemicals converge to support a mode of action.

Cruzan G, Bus J, Banton M, Gingell R, Carlson G.

Regul Toxicol Pharmacol. 2009 Nov;55(2):205-18. doi: 10.1016/j.yrtph.2009.07.002. Epub 2009 Jul 7. Review.

PMID:
19589367
[PubMed - indexed for MEDLINE]
13.

Toxicology and risk assessment of coumarin: focus on human data.

Abraham K, Wöhrlin F, Lindtner O, Heinemeyer G, Lampen A.

Mol Nutr Food Res. 2010 Feb;54(2):228-39. doi: 10.1002/mnfr.200900281. Review.

PMID:
20024932
[PubMed - indexed for MEDLINE]
14.
15.

Physiologically based toxicokinetic modelling as a tool to assess target organ toxicity in route-to-route extrapolation--the case of coumarin.

Mielke H, Abraham K, Götz M, Vieth B, Lampen A, Luch A, Gundert-Remy U.

Toxicol Lett. 2011 Apr 25;202(2):100-10. doi: 10.1016/j.toxlet.2011.01.022. Epub 2011 Feb 1.

PMID:
21291965
[PubMed - indexed for MEDLINE]
17.

Species differences in the metabolism and hepatotoxicity of coumarin.

Fentem JH, Fry JR.

Comp Biochem Physiol C. 1993 Jan;104(1):1-8. Review.

PMID:
8097443
[PubMed - indexed for MEDLINE]
19.
20.

Coumarin toxicity in different strains of mice.

Endell W, Seidel G.

Agents Actions. 1978 Apr;8(3):299-302.

PMID:
665441
[PubMed - indexed for MEDLINE]
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