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Items: 1 to 20 of 340

1.

Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes.

Gunton JE, Kulkarni RN, Yim S, Okada T, Hawthorne WJ, Tseng YH, Roberson RS, Ricordi C, O'Connell PJ, Gonzalez FJ, Kahn CR.

Cell. 2005 Aug 12;122(3):337-49.

2.

Diabetic pancreatic beta cells ARNT all they should be.

Levisetti MG, Polonsky KS.

Cell Metab. 2005 Aug;2(2):78-80.

3.

Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion.

Ling C, Del Guerra S, Lupi R, Rönn T, Granhall C, Luthman H, Masiello P, Marchetti P, Groop L, Del Prato S.

Diabetologia. 2008 Apr;51(4):615-22. doi: 10.1007/s00125-007-0916-5. Epub 2008 Feb 13.

5.

The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.

Marchetti P, Bugliani M, Lupi R, Marselli L, Masini M, Boggi U, Filipponi F, Weir GC, Eizirik DL, Cnop M.

Diabetologia. 2007 Dec;50(12):2486-94. Epub 2007 Sep 30.

PMID:
17906960
6.

Clock-controlled output gene Dbp is a regulator of Arnt/Hif-1β gene expression in pancreatic islet β-cells.

Nakabayashi H, Ohta Y, Yamamoto M, Susuki Y, Taguchi A, Tanabe K, Kondo M, Hatanaka M, Nagao Y, Tanizawa Y.

Biochem Biophys Res Commun. 2013 May 3;434(2):370-5. doi: 10.1016/j.bbrc.2013.03.084. Epub 2013 Apr 6.

PMID:
23567972
7.

Evolution of beta-cell dysfunction in the male Zucker diabetic fatty rat.

Tokuyama Y, Sturis J, DePaoli AM, Takeda J, Stoffel M, Tang J, Sun X, Polonsky KS, Bell GI.

Diabetes. 1995 Dec;44(12):1447-57.

PMID:
7589853
8.
9.

Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism.

Shih DQ, Screenan S, Munoz KN, Philipson L, Pontoglio M, Yaniv M, Polonsky KS, Stoffel M.

Diabetes. 2001 Nov;50(11):2472-80.

10.

Aryl hydrocarbon receptor nuclear translocator/hypoxia-inducible factor-1{beta} plays a critical role in maintaining glucose-stimulated anaplerosis and insulin release from pancreatic {beta}-cells.

Pillai R, Huypens P, Huang M, Schaefer S, Sheinin T, Wettig SD, Joseph JW.

J Biol Chem. 2011 Jan 14;286(2):1014-24. doi: 10.1074/jbc.M110.149062. Epub 2010 Nov 8.

11.

Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and secretion.

Ohsugi M, Cras-Méneur C, Zhou Y, Bernal-Mizrachi E, Johnson JD, Luciani DS, Polonsky KS, Permutt MA.

J Biol Chem. 2005 Feb 11;280(6):4992-5003. Epub 2004 Nov 15.

12.

Anx7 is required for nutritional control of gene expression in mouse pancreatic islets of Langerhans.

Srivastava M, Eidelman O, Leighton X, Glasman M, Goping G, Pollard HB.

Mol Med. 2002 Dec;8(12):781-97.

13.

Influence of diabetes on the loss of beta cell differentiation after islet transplantation in rats.

Laybutt DR, Hawkins YC, Lock J, Lebet J, Sharma A, Bonner-Weir S, Weir GC.

Diabetologia. 2007 Oct;50(10):2117-25. Epub 2007 Jul 20.

PMID:
17641871
14.

Intestinal glucose-dependent expression of glucose-6-phosphatase: involvement of the aryl receptor nuclear translocator transcription factor.

Carrière V, Le Gall M, Gouyon-Saumande F, Schmoll D, Brot-Laroche E, Chauffeton V, Chambaz J, Rousset M.

J Biol Chem. 2005 May 20;280(20):20094-101. Epub 2005 Mar 14.

15.

Role of oxidative stress in pancreatic beta-cell dysfunction.

Kajimoto Y, Kaneto H.

Ann N Y Acad Sci. 2004 Apr;1011:168-76.

PMID:
15126294
16.

Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice.

Otani K, Kulkarni RN, Baldwin AC, Krutzfeldt J, Ueki K, Stoffel M, Kahn CR, Polonsky KS.

Am J Physiol Endocrinol Metab. 2004 Jan;286(1):E41-9. Epub 2003 Sep 30.

17.

Overexpression of dominant-negative mutant hepatocyte nuclear fctor-1 alpha in pancreatic beta-cells causes abnormal islet architecture with decreased expression of E-cadherin, reduced beta-cell proliferation, and diabetes.

Yamagata K, Nammo T, Moriwaki M, Ihara A, Iizuka K, Yang Q, Satoh T, Li M, Uenaka R, Okita K, Iwahashi H, Zhu Q, Cao Y, Imagawa A, Tochino Y, Hanafusa T, Miyagawa J, Matsuzawa Y.

Diabetes. 2002 Jan;51(1):114-23.

18.

Insulin signalling in islets.

Persaud SJ, Muller D, Jones PM.

Biochem Soc Trans. 2008 Jun;36(Pt 3):290-3. doi: 10.1042/BST0360290.

PMID:
18481944
19.

Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice.

Gorogawa S, Fujitani Y, Kaneto H, Hazama Y, Watada H, Miyamoto Y, Takeda K, Akira S, Magnuson MA, Yamasaki Y, Kajimoto Y, Hori M.

Biochem Biophys Res Commun. 2004 Jul 9;319(4):1159-70.

PMID:
15194489
20.

Changes in gene expression in beta cells after islet isolation and transplantation using laser-capture microdissection.

Ahn YB, Xu G, Marselli L, Toschi E, Sharma A, Bonner-Weir S, Sgroi DC, Weir GC.

Diabetologia. 2007 Feb;50(2):334-42. Epub 2006 Dec 16.

PMID:
17180350
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