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Items: 1 to 20 of 141

1.

Regulation of mTOR and cell growth in response to energy stress by REDD1.

Sofer A, Lei K, Johannessen CM, Ellisen LW.

Mol Cell Biol. 2005 Jul;25(14):5834-45.

2.

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex.

Brugarolas J, Lei K, Hurley RL, Manning BD, Reiling JH, Hafen E, Witters LA, Ellisen LW, Kaelin WG Jr.

Genes Dev. 2004 Dec 1;18(23):2893-904. Epub 2004 Nov 15.

3.
4.

Growth control under stress: mTOR regulation through the REDD1-TSC pathway.

Ellisen LW.

Cell Cycle. 2005 Nov;4(11):1500-02. Epub 2005 Nov 1. Review.

PMID:
16258273
5.

The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses.

Smith EM, Finn SG, Tee AR, Browne GJ, Proud CG.

J Biol Chem. 2005 May 13;280(19):18717-27. Epub 2005 Mar 16.

6.

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.

Inoki K, Li Y, Xu T, Guan KL.

Genes Dev. 2003 Aug 1;17(15):1829-34. Epub 2003 Jul 17.

7.

Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation.

Uhlmann EJ, Li W, Scheidenhelm DK, Gau CL, Tamanoi F, Gutmann DH.

Glia. 2004 Aug 1;47(2):180-8.

PMID:
15185396
8.

Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent.

Karbowniczek M, Cash T, Cheung M, Robertson GP, Astrinidis A, Henske EP.

J Biol Chem. 2004 Jul 16;279(29):29930-7. Epub 2004 May 18.

9.

Rheb binds and regulates the mTOR kinase.

Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J.

Curr Biol. 2005 Apr 26;15(8):702-13.

10.

Dexamethasone represses signaling through the mammalian target of rapamycin in muscle cells by enhancing expression of REDD1.

Wang H, Kubica N, Ellisen LW, Jefferson LS, Kimball SR.

J Biol Chem. 2006 Dec 22;281(51):39128-34. Epub 2006 Oct 30.

11.

Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis.

Kimball SR, Do AN, Kutzler L, Cavener DR, Jefferson LS.

J Biol Chem. 2008 Feb 8;283(6):3465-75. Epub 2007 Dec 10.

13.

Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling.

DeYoung MP, Horak P, Sofer A, Sgroi D, Ellisen LW.

Genes Dev. 2008 Jan 15;22(2):239-51. doi: 10.1101/gad.1617608.

14.

Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity.

Hahn-Windgassen A, Nogueira V, Chen CC, Skeen JE, Sonenberg N, Hay N.

J Biol Chem. 2005 Sep 16;280(37):32081-9. Epub 2005 Jul 15.

15.

Acute alcohol intoxication increases REDD1 in skeletal muscle.

Lang CH, Frost RA, Vary TC.

Alcohol Clin Exp Res. 2008 May;32(5):796-805. doi: 10.1111/j.1530-0277.2008.00637.x. Epub 2008 Mar 11.

PMID:
18336631
16.

TSC2: filling the GAP in the mTOR signaling pathway.

Li Y, Corradetti MN, Inoki K, Guan KL.

Trends Biochem Sci. 2004 Jan;29(1):32-8. Review.

PMID:
14729330
17.

Hypoxia-induced energy stress regulates mRNA translation and cell growth.

Liu L, Cash TP, Jones RG, Keith B, Thompson CB, Simon MC.

Mol Cell. 2006 Feb 17;21(4):521-31.

19.

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2.

Garami A, Zwartkruis FJ, Nobukuni T, Joaquin M, Roccio M, Stocker H, Kozma SC, Hafen E, Bos JL, Thomas G.

Mol Cell. 2003 Jun;11(6):1457-66.

20.
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