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Results: 1 to 20 of 92

1.

Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling.

Chavez JA, Holland WL, Bär J, Sandhoff K, Summers SA.

J Biol Chem. 2005 May 20;280(20):20148-53. Epub 2005 Mar 17.

PMID:
15774472
[PubMed - indexed for MEDLINE]
Free Article
2.
3.

A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids.

Chavez JA, Knotts TA, Wang LP, Li G, Dobrowsky RT, Florant GL, Summers SA.

J Biol Chem. 2003 Mar 21;278(12):10297-303. Epub 2003 Jan 13.

PMID:
12525490
[PubMed - indexed for MEDLINE]
Free Article
4.

Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate.

Schmitz-Peiffer C, Craig DL, Biden TJ.

J Biol Chem. 1999 Aug 20;274(34):24202-10.

PMID:
10446195
[PubMed - indexed for MEDLINE]
Free Article
5.

Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-kappaB.

Weigert C, Brodbeck K, Staiger H, Kausch C, Machicao F, Häring HU, Schleicher ED.

J Biol Chem. 2004 Jun 4;279(23):23942-52. Epub 2004 Mar 17.

PMID:
15028733
[PubMed - indexed for MEDLINE]
Free Article
6.

Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B.

Stratford S, Hoehn KL, Liu F, Summers SA.

J Biol Chem. 2004 Aug 27;279(35):36608-15. Epub 2004 Jun 25.

PMID:
15220355
[PubMed - indexed for MEDLINE]
Free Article
7.

Modulation of cellular insulin signaling and PTP1B effects by lipid metabolites in skeletal muscle cells.

Obanda DN, Cefalu WT.

J Nutr Biochem. 2013 Aug;24(8):1529-37. doi: 10.1016/j.jnutbio.2012.12.014. Epub 2013 Mar 6.

PMID:
23481236
[PubMed - indexed for MEDLINE]
8.

Free fatty acids inhibit insulin signaling-stimulated endothelial nitric oxide synthase activation through upregulating PTEN or inhibiting Akt kinase.

Wang XL, Zhang L, Youker K, Zhang MX, Wang J, LeMaire SA, Coselli JS, Shen YH.

Diabetes. 2006 Aug;55(8):2301-10.

PMID:
16873694
[PubMed - indexed for MEDLINE]
Free Article
9.

No in vitro effects of fatty acids on glucose uptake, lipolysis or insulin signaling in rat adipocytes.

Lundgren M, Eriksson JW.

Horm Metab Res. 2004 Apr;36(4):203-9.

PMID:
15114517
[PubMed - indexed for MEDLINE]
10.

Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide.

Summers SA, Garza LA, Zhou H, Birnbaum MJ.

Mol Cell Biol. 1998 Sep;18(9):5457-64.

PMID:
9710629
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Suppression of free fatty acid-induced insulin resistance by phytopolyphenols in C2C12 mouse skeletal muscle cells.

Deng YT, Chang TW, Lee MS, Lin JK.

J Agric Food Chem. 2012 Feb 1;60(4):1059-66. doi: 10.1021/jf204496f. Epub 2012 Jan 17.

PMID:
22191431
[PubMed - indexed for MEDLINE]
13.

Human triglyceride-rich lipoproteins impair glucose metabolism and insulin signalling in L6 skeletal muscle cells independently of non-esterified fatty acid levels.

Pedrini MT, Kranebitter M, Niederwanger A, Kaser S, Engl J, Debbage P, Huber LA, Patsch JR.

Diabetologia. 2005 Apr;48(4):756-66. Epub 2005 Mar 4.

PMID:
15747109
[PubMed - indexed for MEDLINE]
14.

Free fatty acids inhibit serum deprivation-induced apoptosis through GPR120 in a murine enteroendocrine cell line STC-1.

Katsuma S, Hatae N, Yano T, Ruike Y, Kimura M, Hirasawa A, Tsujimoto G.

J Biol Chem. 2005 May 20;280(20):19507-15. Epub 2005 Mar 17.

PMID:
15774482
[PubMed - indexed for MEDLINE]
Free Article
15.

Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells.

Hirabara SM, Curi R, Maechler P.

J Cell Physiol. 2010 Jan;222(1):187-94. doi: 10.1002/jcp.21936.

PMID:
19780047
[PubMed - indexed for MEDLINE]
16.

Ceramide mediates inhibition of the AKT/eNOS signaling pathway by palmitate in human vascular endothelial cells.

Xiao-Yun X, Zhuo-Xiong C, Min-Xiang L, Xingxuan H, Schuchman EH, Feng L, Han-Song X, An-Hua L.

Med Sci Monit. 2009 Sep;15(9):BR254-61.

PMID:
19721393
[PubMed - indexed for MEDLINE]
17.

A role for protein phosphatase 2A-like activity, but not atypical protein kinase Czeta, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitate.

Cazzolli R, Carpenter L, Biden TJ, Schmitz-Peiffer C.

Diabetes. 2001 Oct;50(10):2210-8.

PMID:
11574400
[PubMed - indexed for MEDLINE]
Free Article
18.

Fatty acid-induced insulin resistance in L6 myotubes is prevented by inhibition of activation and nuclear localization of nuclear factor kappa B.

Sinha S, Perdomo G, Brown NF, O'Doherty RM.

J Biol Chem. 2004 Oct 1;279(40):41294-301. Epub 2004 Jul 12.

PMID:
15252018
[PubMed - indexed for MEDLINE]
Free Article
19.

Acid ceramidase and human disease.

Park JH, Schuchman EH.

Biochim Biophys Acta. 2006 Dec;1758(12):2133-8. Epub 2006 Sep 1. Review.

PMID:
17064658
[PubMed - indexed for MEDLINE]
Free Article
20.

Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells.

Hajduch E, Balendran A, Batty IH, Litherland GJ, Blair AS, Downes CP, Hundal HS.

Diabetologia. 2001 Feb;44(2):173-83.

PMID:
11270673
[PubMed - indexed for MEDLINE]
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