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Items: 1 to 20 of 118

1.

Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death.

Blum R, Jacob-Hirsch J, Amariglio N, Rechavi G, Kloog Y.

Cancer Res. 2005 Feb 1;65(3):999-1006.

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3.

Gene expression signature of human cancer cell lines treated with the ras inhibitor salirasib (S-farnesylthiosalicylic acid).

Blum R, Elkon R, Yaari S, Zundelevich A, Jacob-Hirsch J, Rechavi G, Shamir R, Kloog Y.

Cancer Res. 2007 Apr 1;67(7):3320-8.

4.

Ras inhibition results in growth arrest and death of androgen-dependent and androgen-independent prostate cancer cells.

Erlich S, Tal-Or P, Liebling R, Blum R, Karunagaran D, Kloog Y, Pinkas-Kramarski R.

Biochem Pharmacol. 2006 Aug 14;72(4):427-36. Epub 2006 May 13.

PMID:
16780807
5.

The Ras inhibitor farnesylthiosalicylic acid as a potential therapy for neurofibromatosis type 1.

Barkan B, Starinsky S, Friedman E, Stein R, Kloog Y.

Clin Cancer Res. 2006 Sep 15;12(18):5533-42.

PMID:
17000690
6.

Galectin-3 promotes chronic activation of K-Ras and differentiation block in malignant thyroid carcinomas.

Levy R, Grafi-Cohen M, Kraiem Z, Kloog Y.

Mol Cancer Ther. 2010 Aug;9(8):2208-19. doi: 10.1158/1535-7163.MCT-10-0262. Epub 2010 Aug 3.

7.

SNS-032 prevents hypoxia-mediated glioblastoma cell invasion by inhibiting hypoxia inducible factor-1alpha expression.

Ali MA, Reis A, Ding LH, Story MD, Habib AA, Chattopadhyay A, Saha D.

Int J Oncol. 2009 Apr;34(4):1051-60.

PMID:
19287962
8.

Hypoxia-independent overexpression of hypoxia-inducible factor 1alpha as an early change in mouse hepatocarcinogenesis.

Tanaka H, Yamamoto M, Hashimoto N, Miyakoshi M, Tamakawa S, Yoshie M, Tokusashi Y, Yokoyama K, Yaginuma Y, Ogawa K.

Cancer Res. 2006 Dec 1;66(23):11263-70.

10.

E2F1 identified by promoter and biochemical analysis as a central target of glioblastoma cell-cycle arrest in response to Ras inhibition.

Blum R, Nakdimon I, Goldberg L, Elkon R, Shamir R, Rechavi G, Kloog Y.

Int J Cancer. 2006 Aug 1;119(3):527-38.

11.

Phenotypic reversion of invasive neurofibromin-deficient schwannoma by FTS: Ras inhibition reduces BMP4/Erk/Smad signaling.

Barkan B, Kloog Y, Ehrlich M.

Mol Cancer Ther. 2011 Aug;10(8):1317-26. doi: 10.1158/1535-7163.MCT-10-1087. Epub 2011 Jun 1.

12.

Disruption of cooperation between Ras and MycN in human neuroblastoma cells promotes growth arrest.

Yaari S, Jacob-Hirsch J, Amariglio N, Haklai R, Rechavi G, Kloog Y.

Clin Cancer Res. 2005 Jun 15;11(12):4321-30.

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14.

Adenosine modulates vascular endothelial growth factor expression via hypoxia-inducible factor-1 in human glioblastoma cells.

Merighi S, Benini A, Mirandola P, Gessi S, Varani K, Leung E, Maclennan S, Borea PA.

Biochem Pharmacol. 2006 Jun 28;72(1):19-31. Epub 2006 Mar 29.

PMID:
16682012
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17.

The Ras-pathway inhibitor, S-trans-trans-farnesylthiosalicylic acid, suppresses experimental allergic encephalomyelitis.

Karussis D, Abramsky O, Grigoriadis N, Chapman J, Mizrachi-Koll R, Niv H, Kloog Y.

J Neuroimmunol. 2001 Nov 1;120(1-2):1-9.

PMID:
11694313
18.

HIF1-positive and HIF1-negative glioblastoma cells compete in vitro but cooperate in tumor growth in vivo.

Fiorenzo P, Mongiardi MP, Dimitri D, Cozzolino M, Ferri A, Montano N, Trevisi G, Maira G, Battistini L, Falchetti ML, Levi A, Pallini R.

Int J Oncol. 2010 Apr;36(4):785-91.

PMID:
20198320
19.
20.

Stem cell factor induces HIF-1alpha at normoxia in hematopoietic cells.

Pedersen M, Löfstedt T, Sun J, Holmquist-Mengelbier L, Påhlman S, Rönnstrand L.

Biochem Biophys Res Commun. 2008 Dec 5;377(1):98-103. doi: 10.1016/j.bbrc.2008.09.102. Epub 2008 Oct 1.

PMID:
18834862
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