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Items: 1 to 20 of 133

1.

Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry.

Lee W, Glaeser H, Smith LH, Roberts RL, Moeckel GW, Gervasini G, Leake BF, Kim RB.

J Biol Chem. 2005 Mar 11;280(10):9610-7. Epub 2005 Jan 4.

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Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants.

Badagnani I, Castro RA, Taylor TR, Brett CM, Huang CC, Stryke D, Kawamoto M, Johns SJ, Ferrin TE, Carlson EJ, Burchard EG, Giacomini KM.

J Pharmacol Exp Ther. 2006 Aug;318(2):521-9. Epub 2006 May 15.

5.

Molecular cloning and functional characterization of the bovine (Bos taurus) organic anion transporting polypeptide Oatp1a2 (Slco1a2).

Geyer J, Döring B, Failing K, Petzinger E.

Comp Biochem Physiol B Biochem Mol Biol. 2004 Mar;137(3):317-29.

PMID:
15050519
7.

Putative transmembrane domain 6 of the human organic anion transporting polypeptide 1A2 (OATP1A2) influences transporter substrate binding, protein trafficking, and quality control.

Chan T, Zheng J, Zhu L, Grewal T, Murray M, Zhou F.

Mol Pharm. 2015 Jan 5;12(1):111-9. doi: 10.1021/mp500459b. Epub 2014 Nov 20.

PMID:
25387129
8.

A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter.

Michalski C, Cui Y, Nies AT, Nuessler AK, Neuhaus P, Zanger UM, Klein K, Eichelbaum M, Keppler D, Konig J.

J Biol Chem. 2002 Nov 8;277(45):43058-63. Epub 2002 Aug 23.

9.

Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis.

Nozawa T, Nakajima M, Tamai I, Noda K, Nezu J, Sai Y, Tsuji A, Yokoi T.

J Pharmacol Exp Ther. 2002 Aug;302(2):804-13.

10.

Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics.

Nishizato Y, Ieiri I, Suzuki H, Kimura M, Kawabata K, Hirota T, Takane H, Irie S, Kusuhara H, Urasaki Y, Urae A, Higuchi S, Otsubo K, Sugiyama Y.

Clin Pharmacol Ther. 2003 Jun;73(6):554-65.

PMID:
12811365
11.

Functional analysis of novel polymorphisms in the human SLCO1A2 gene that encodes the transporter OATP1A2.

Zhou F, Zheng J, Zhu L, Jodal A, Cui PH, Wong M, Gurney H, Church WB, Murray M.

AAPS J. 2013 Oct;15(4):1099-108. doi: 10.1208/s12248-013-9515-1. Epub 2013 Aug 6.

12.

Identification of novel functional organic anion-transporting polypeptide 1B3 polymorphisms and assessment of substrate specificity.

Schwarz UI, Meyer zu Schwabedissen HE, Tirona RG, Suzuki A, Leake BF, Mokrab Y, Mizuguchi K, Ho RH, Kim RB.

Pharmacogenet Genomics. 2011 Mar;21(3):103-14. doi: 10.1097/FPC.0b013e328342f5b1.

13.

Functional effects of protein sequence polymorphisms in the organic cation/ergothioneine transporter OCTN1 (SLC22A4).

Urban TJ, Yang C, Lagpacan LL, Brown C, Castro RA, Taylor TR, Huang CC, Stryke D, Johns SJ, Kawamoto M, Carlson EJ, Ferrin TE, Burchard EG, Giacomini KM.

Pharmacogenet Genomics. 2007 Sep;17(9):773-82.

PMID:
17700366
14.

Identification, expression, and functional characterization of full-length and splice variants of murine organic anion transporting polypeptide 1b2.

Meyer Zu Schwabedissen HE, Ware JA, Tirona RG, Kim RB.

Mol Pharm. 2009 Nov-Dec;6(6):1790-7. doi: 10.1021/mp900030w.

PMID:
19400585
15.

Functional analysis of single nucleotide polymorphisms of hepatic organic anion transporter OATP1B1 (OATP-C).

Iwai M, Suzuki H, Ieiri I, Otsubo K, Sugiyama Y.

Pharmacogenetics. 2004 Nov;14(11):749-57.

PMID:
15564882
16.

Cloning and functional characterization of the pig (Sus scrofa) organic anion transporting polypeptide 1a2.

Yu Y, Liu X, Zhang Z, Xiao Y, Hong M.

Xenobiotica. 2013 Aug;43(8):738-44. doi: 10.3109/00498254.2012.760762. Epub 2013 Jan 16.

PMID:
23323548
17.

The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics.

Erdman AR, Mangravite LM, Urban TJ, Lagpacan LL, Castro RA, de la Cruz M, Chan W, Huang CC, Johns SJ, Kawamoto M, Stryke D, Taylor TR, Carlson EJ, Ferrin TE, Brett CM, Burchard EG, Giacomini KM.

Am J Physiol Renal Physiol. 2006 Apr;290(4):F905-12. Epub 2005 Nov 15.

18.

Genetic polymorphisms and function of the organic anion-transporting polypeptide 1A2 and its clinical relevance in drug disposition.

Zhou Y, Yuan J, Li Z, Wang Z, Cheng D, Du Y, Li W, Kan Q, Zhang W.

Pharmacology. 2015;95(3-4):201-8. doi: 10.1159/000381313. Epub 2015 Apr 23. Review.

19.

Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics.

Ho RH, Tirona RG, Leake BF, Glaeser H, Lee W, Lemke CJ, Wang Y, Kim RB.

Gastroenterology. 2006 May;130(6):1793-806. Epub 2006 Mar 6.

PMID:
16697742
20.

Quantitative structure--activity relationship analysis and molecular dynamics simulation to functionally validate nonsynonymous polymorphisms of human ABC transporter ABCB1 (P-glycoprotein/MDR1).

Sakurai A, Onishi Y, Hirano H, Seigneuret M, Obanayama K, Kim G, Liew EL, Sakaeda T, Yoshiura K, Niikawa N, Sakurai M, Ishikawa T.

Biochemistry. 2007 Jul 3;46(26):7678-93. Epub 2007 Jun 9.

PMID:
17559192
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