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ATP hydrolysis by ORC catalyzes reiterative Mcm2-7 assembly at a defined origin of replication.

Bowers JL, Randell JC, Chen S, Bell SP.

Mol Cell. 2004 Dec 22;16(6):967-78.


Sequential ATP hydrolysis by Cdc6 and ORC directs loading of the Mcm2-7 helicase.

Randell JC, Bowers JL, Rodríguez HK, Bell SP.

Mol Cell. 2006 Jan 6;21(1):29-39.


An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer assembly.

Fernández-Cid A, Riera A, Tognetti S, Herrera MC, Samel S, Evrin C, Winkler C, Gardenal E, Uhle S, Speck C.

Mol Cell. 2013 May 23;50(4):577-88. doi: 10.1016/j.molcel.2013.03.026. Epub 2013 Apr 18.


In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization.

Evrin C, Fernández-Cid A, Zech J, Herrera MC, Riera A, Clarke P, Brill S, Lurz R, Speck C.

Nucleic Acids Res. 2013 Mar 1;41(5):3162-72. doi: 10.1093/nar/gkt043. Epub 2013 Feb 1.


Dynamics of pre-replicative complex assembly.

Tsakraklides V, Bell SP.

J Biol Chem. 2010 Mar 26;285(13):9437-43. doi: 10.1074/jbc.M109.072504. Epub 2010 Jan 22.


ATP bound to the origin recognition complex is important for preRC formation.

Klemm RD, Bell SP.

Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8361-7.


A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication.

Evrin C, Clarke P, Zech J, Lurz R, Sun J, Uhle S, Li H, Stillman B, Speck C.

Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20240-5. doi: 10.1073/pnas.0911500106. Epub 2009 Nov 12.


Orc6 is required for dynamic recruitment of Cdt1 during repeated Mcm2-7 loading.

Chen S, de Vries MA, Bell SP.

Genes Dev. 2007 Nov 15;21(22):2897-907.


Reconstitution of Saccharomyces cerevisiae prereplicative complex assembly in vitro.

Kawasaki Y, Kim HD, Kojima A, Seki T, Sugino A.

Genes Cells. 2006 Jul;11(7):745-56.


Multiple Cdt1 molecules act at each origin to load replication-competent Mcm2-7 helicases.

Takara TJ, Bell SP.

EMBO J. 2011 Nov 1;30(24):4885-96. doi: 10.1038/emboj.2011.394.


The ORC/Cdc6/MCM2-7 complex facilitates MCM2-7 dimerization during prereplicative complex formation.

Evrin C, Fernández-Cid A, Riera A, Zech J, Clarke P, Herrera MC, Tognetti S, Lurz R, Speck C.

Nucleic Acids Res. 2014 Feb;42(4):2257-69. doi: 10.1093/nar/gkt1148. Epub 2013 Nov 14.


Stepwise assembly of initiation proteins at budding yeast replication origins in vitro.

Seki T, Diffley JF.

Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14115-20.


Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells.

Kneissl M, Pütter V, Szalay AA, Grummt F.

J Mol Biol. 2003 Mar 14;327(1):111-28.


Linkage between phosphorylation of the origin recognition complex and its ATP binding activity in Saccharomyces cerevisiae.

Makise M, Takehara M, Kuniyasu A, Matsui N, Nakayama H, Mizushima T.

J Biol Chem. 2009 Feb 6;284(6):3396-407. doi: 10.1074/jbc.M804293200. Epub 2008 Dec 8.


Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing.

Remus D, Beuron F, Tolun G, Griffith JD, Morris EP, Diffley JF.

Cell. 2009 Nov 13;139(4):719-30. doi: 10.1016/j.cell.2009.10.015. Epub 2009 Nov 5.


The ATPase activity of MCM2-7 is dispensable for pre-RC assembly but is required for DNA unwinding.

Ying CY, Gautier J.

EMBO J. 2005 Dec 21;24(24):4334-44. Epub 2005 Nov 24.


Cell cycle execution point analysis of ORC function and characterization of the checkpoint response to ORC inactivation in Saccharomyces cerevisiae.

Gibson DG, Bell SP, Aparicio OM.

Genes Cells. 2006 Jun;11(6):557-73. Erratum in: Genes Cells. 2006 Aug;11(8):969.


Origin recognition complex binding to a metazoan replication origin.

Bielinsky AK, Blitzblau H, Beall EL, Ezrokhi M, Smith HS, Botchan MR, Gerbi SA.

Curr Biol. 2001 Sep 18;11(18):1427-31.

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