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Results: 1 to 20 of 168

1.

Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.

Crabbe L, Verdun RE, Haggblom CI, Karlseder J.

Science. 2004 Dec 10;306(5703):1951-3.

PMID:
15591207
[PubMed - indexed for MEDLINE]
Free Article
2.

Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway.

Laud PR, Multani AS, Bailey SM, Wu L, Ma J, Kingsley C, Lebel M, Pathak S, DePinho RA, Chang S.

Genes Dev. 2005 Nov 1;19(21):2560-70.

PMID:
16264192
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Telomere instability in a human tumor cell line expressing a dominant-negative WRN protein.

Bai Y, Murnane JP.

Hum Genet. 2003 Sep;113(4):337-47. Epub 2003 Jun 25.

PMID:
12827497
[PubMed - indexed for MEDLINE]
4.

The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2.

Opresko PL, Otterlei M, Graakjaer J, Bruheim P, Dawut L, Kølvraa S, May A, Seidman MM, Bohr VA.

Mol Cell. 2004 Jun 18;14(6):763-74.

PMID:
15200954
[PubMed - indexed for MEDLINE]
Free Article
5.

WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening.

Li B, Jog SP, Reddy S, Comai L.

Mol Cell Biol. 2008 Mar;28(6):1892-904. doi: 10.1128/MCB.01364-07. Epub 2008 Jan 22.

PMID:
18212065
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts.

Hisama FM, Chen YH, Meyn MS, Oshima J, Weissman SM.

Cancer Res. 2000 May 1;60(9):2372-6.

PMID:
10811112
[PubMed - indexed for MEDLINE]
Free Article
7.

Telomere dysfunction as a cause of genomic instability in Werner syndrome.

Crabbe L, Jauch A, Naeger CM, Holtgreve-Grez H, Karlseder J.

Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2205-10. Epub 2007 Feb 6.

PMID:
17284601
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle.

Pichierri P, Rosselli F, Franchitto A.

Oncogene. 2003 Mar 13;22(10):1491-500.

PMID:
12629512
[PubMed - indexed for MEDLINE]
9.

POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates.

Opresko PL, Mason PA, Podell ER, Lei M, Hickson ID, Cech TR, Bohr VA.

J Biol Chem. 2005 Sep 16;280(37):32069-80. Epub 2005 Jul 18.

PMID:
16030011
[PubMed - indexed for MEDLINE]
Free Article
10.

Coordinate action of the helicase and 3' to 5' exonuclease of Werner syndrome protein.

Opresko PL, Laine JP, Brosh RM Jr, Seidman MM, Bohr VA.

J Biol Chem. 2001 Nov 30;276(48):44677-87. Epub 2001 Sep 25.

PMID:
11572872
[PubMed - indexed for MEDLINE]
Free Article
11.

The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase.

Johnson FB, Marciniak RA, McVey M, Stewart SA, Hahn WC, Guarente L.

EMBO J. 2001 Feb 15;20(4):905-13.

PMID:
11179234
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

p53 modulates RPA-dependent and RPA-independent WRN helicase activity.

Sommers JA, Sharma S, Doherty KM, Karmakar P, Yang Q, Kenny MK, Harris CC, Brosh RM Jr.

Cancer Res. 2005 Feb 15;65(4):1223-33.

PMID:
15735006
[PubMed - indexed for MEDLINE]
Free Article
13.

Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases.

Opresko PL, von Kobbe C, Laine JP, Harrigan J, Hickson ID, Bohr VA.

J Biol Chem. 2002 Oct 25;277(43):41110-9. Epub 2002 Aug 13.

PMID:
12181313
[PubMed - indexed for MEDLINE]
Free Article
14.

Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells.

Futami K, Ishikawa Y, Goto M, Furuichi Y, Sugimoto M.

Cancer Sci. 2008 May;99(5):843-8. doi: 10.1111/j.1349-7006.2008.00778.x. Epub 2008 Feb 26. Review.

PMID:
18312465
[PubMed - indexed for MEDLINE]
15.

TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNA.

Machwe A, Xiao L, Orren DK.

Oncogene. 2004 Jan 8;23(1):149-56.

PMID:
14712220
[PubMed - indexed for MEDLINE]
16.

The Werner syndrome protein suppresses telomeric instability caused by chromium (VI) induced DNA replication stress.

Liu FJ, Barchowsky A, Opresko PL.

PLoS One. 2010 Jun 16;5(6):e11152. doi: 10.1371/journal.pone.0011152.

PMID:
20585393
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase.

Cohen H, Sinclair DA.

Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3174-9. Epub 2001 Mar 6.

PMID:
11248051
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Competition between the DNA unwinding and strand pairing activities of the Werner and Bloom syndrome proteins.

Machwe A, Lozada EM, Xiao L, Orren DK.

BMC Mol Biol. 2006 Jan 13;7:1.

PMID:
16412221
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

The Werner syndrome helicase/exonuclease (WRN) disrupts and degrades D-loops in vitro.

Orren DK, Theodore S, Machwe A.

Biochemistry. 2002 Nov 19;41(46):13483-8.

PMID:
12427008
[PubMed - indexed for MEDLINE]
20.

Werner syndrome: molecular insights into the relationships between defective DNA metabolism, genomic instability, cancer and aging.

Orren DK.

Front Biosci. 2006 Sep 1;11:2657-71. Review.

PMID:
16720342
[PubMed - indexed for MEDLINE]

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